Motion sickness and migraine: optokinetic stimulation increases scalp tenderness, pain sensitivity in the fingers and photophobia [PDF]
, 2002 The aim of this study was to determine whether scalp tenderness and photophobia, two well-recognized symptoms of migraine, develop during the motion sickness induced by optokinetic stimulation.
Drummond, P.D.
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Antinociceptive effects of lacosamide on spinal neuronal and behavioural measures of pain in a rat model of osteoarthritis. [PDF]
, 2014 Alterations in voltage-gated sodium channel (VGSC) function have been linked to chronic pain and are good targets for analgesics. Lacosamide (LCM) is a novel anticonvulsant that enhances the slow inactivation state of VGSCs. This conformational state can
Wahida Rahman +3 more
core +1 more source
Neuronal NTPDase3 Mediates Extracellular ATP Degradation in Trigeminal Nociceptive Pathway.
PLoS ONE, 2016 ATP induces pain via activation of purinergic receptors in nociceptive sensory nerves. ATP signaling is terminated by ATP hydrolysis mediated by cell surface-localized ecto-nucleotidases.
Lihua Ma +4 more
doaj +1 more source
The effects of a co-application of menthol and capsaicin on nociceptive behaviors of the rat on the operant orofacial pain assessment device. [PDF]
PLoS ONE, 2014 Transient receptor potential (TRP) cation channels are involved in the perception of hot and cold pain and are targets for pain relief in humans. We hypothesized that agonists of TRPV1 and TRPM8/TRPA1, capsaicin and menthol, would alter nociceptive ...
Ethan M Anderson +3 more
doaj +1 more source
Nociception and pain: lessons from optogenetics [PDF]
Frontiers in Behavioral Neuroscience, 2014 The process of pain perception begins in the periphery by activation of nociceptors. From here nociceptive signals are conveyed via the dorsal horn of the spinal cord to multiple brain regions, where pain is perceived. Despite great progress in pain research in recent years, many questions remain regarding nociceptive circuitry and behavior, in both ...
Carr, Fiona B., Zachariou, Venetia
openaire +3 more sources
Depletion of noradrenaline inhibits electrically-evoked pain in the skin of the human forearm [PDF]
, 2008 Guanethidine displaces noradrenaline from sympathetic varicosities, and blocks sympathetic noradrenergic neurotransmission by inhibiting the release of noradrenaline from depleted neural stores. The aim of this study was to determine whether depletion of
Drummond, P.D.
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PROMIS Neuropathic and Nociceptive Pain Quality in Musculoskeletal Pain Presentations.
, 2021 Objective: Musculoskeletal pain is a significant contributor to the global disease burden. Management of musculoskeletal pain where a neuropathic component is present can be challenging. This study evaluated the internal structure of the Patient-Reported
Chase, B +26 more
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P/Q-type calcium-channel blockade in the periaqueductal gray facilitates trigeminal nociception: a functional genetic link for migraine? [PDF]
, 2002 The discovery of mis-sense mutations in the alpha1A subunit of the P/Q-type calcium channel in patients with familial hemiplegic migraine indicates the potential involvement of dysfunctional ion channels in migraine.
Goadsby, PJ +11 more
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Electrical stimulation decreases neuralgic pain after trigeminal deafferentation [PDF]
, 2008 Trigeminal nerve activity mediates head pain after cranial injuries, and also contributes to idiopathic syndromes such as cluster headache and trigeminal neuralgia. Nevertheless, chronic facial pain sometimes develops after lesion of the trigeminal nerve.
Treleaven-Hassard, S., Drummond, P.D.
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Mechanisms of pain processing: spinal protein translation in the rat [PDF]
, 2009 The word ‘pain’ is described by the International Association for the Study of Pain (IASP) as an unpleasant sensory and emotional experience associated with actual or potential tissue damage, or described in terms of such damage.
Asante, C O, Asante, C.O.
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