Results 141 to 150 of about 49,496 (354)
Recent Developments on Novel 2D Materials for Emerging Neuromorphic Computing Devices
Small StructuresThe rapid advancement of artificial intelligent and information technology has led to a critical need for extremely low power consumption and excellent efficiency.
Muhammad Hamza Pervez +10 more
doaj +1 more source
Soluble epoxide hydrolase limits mechanical hyperalgesia during inflammation
Molecular Pain, 2011 Background Cytochrome-P450 (CYP450) epoxygenases metabolise arachidonic acid (AA) into four different biologically active epoxyeicosatrienoic acid (EET) regioisomers.
Brandes Ralf P +11 more
doaj +1 more source
Novel therapeutic targets for chronic visceral pain in gastrointestinal disorders
British Journal of Pharmacology, EarlyView.Chronic visceral pain imposes a major clinical challenge in gastroenterology and beyond, profoundly impacting patients' quality of life. However, limited understanding of its complex, multifaceted pathophysiology, encompassing both peripheral and central mechanisms, continues to impede the development of effective management strategies.
Fleur Veldman +3 more
wiley +1 more source
Headache: The Journal of Head and Face Pain, EarlyView.Abstract Objectives/Background Chronic migraine is a debilitating neurological disorder characterized by central sensitization and impaired brainstem habituation. OnabotulinumtoxinA is an established prophylactic treatment for chronic migraine, yet its effects on central trigeminal sensory processing remain incompletely understood.
Gerlinde Freimark +8 more
wiley +1 more source
Cephalalgia, 2016 Background Administration of onabotulinumtoxinA (BoNT-A) to peripheral tissues outside the calvaria reduces the number of days chronic migraine patients experience headache.
Xichun Zhang +4 more
semanticscholar +1 more source
The hidden science of haptics: A pedagogical review of tactile evaluation in cosmetics
International Journal of Cosmetic Science, EarlyView.This review explores the physiological basis of tactile perception and critically examines classical and emerging sensory methods used in cosmetics, advocating for broader methodological integration and recognition of sensory analysis in the field. Abstract Sensory analysis is a cornerstone of cosmetic development, yet remains underrepresented in peer ...
Morgane Postec +2 more
wiley +1 more source
Pain pathways and mechanisms of neuropathic pain
Acta Neurológica Colombiana, 2007 Several neural steps are involved in the processing of noxious signals that can lead to the experience of pain. Nociceptors readily respond to different noxious modalities such as thermal, mechanical or chemical stimuli, but nociceptors do not respond ...
Oscar A. de Leon-Casasola
doaj +2 more sources
Sensitization of Primary Afferent Nociceptors Induced by Intradermal Capsaicin Involves the Peripheral Release of Calcitonin Gene-Related Peptide Driven by Dorsal Root Reflexes [PDF]
, 2008 Dingge Li +5 more
openalex +1 more source
Journal of Physiology, 2018 A recent animal study showed that high frequency electrical stimulation (HFS) of C‐fibres induces a gliogenic heterosynaptic long‐term potentiation at the spinal cord that is hypothesized to mediate secondary hyperalgesia in humans.
C. Lenoir +3 more
semanticscholar +1 more source
Inflammatory niches as spatial drivers of disease mechanisms and targets for personalized treatment
Journal of the European Academy of Dermatology and Venereology, EarlyView.This study provides a comprehensive review of how spatial transcriptomics reveals disease‐specific inflammatory niches across multiple skin disorders, highlighting key immune–stromal, neuro–immune and metabolic interactions that were previously unappreciated in non‐spatial analyses. Abstract Disease states are increasingly recognized as being shaped by
Rundong Jiang +3 more
wiley +1 more source