Acta Physiologica, Volume 241, Issue 11, November 2025.ABSTRACT Aim To elucidate the molecular mechanism of cold sensing by visceral sensory endings, a side‐by‐side characterization of cold‐sensitive (CS) neurons in adult mouse trigeminal (TG) and vagal ganglia (VG) was performed. Methods A combination of physiological, pharmacological, molecular, and genetic tools was employed on trigeminal and vagal ...
Katharina Gers‐Barlag +4 more
wiley +1 more source
Adrenergic sensitivity of uninjured C-fiber nociceptors in neuropathic rats
, 2000 Taick Sang Nam +3 more
openalex +1 more source
Excitatory Nicotinic and Desensitizing Muscarinic (M2) Effects on C-Nociceptors in Isolated Rat Skin [PDF]
, 2001 Nadia Bernardini +4 more
openalex +1 more source
Cannabinoid CB2 receptor‐mediated analgesia: mechanism‐based insights and therapeutic potential
British Journal of Pharmacology, Volume 182, Issue 21, Page 5090-5118, November 2025.Agonists of the cannabinoid 2 (CB2) receptor have shown promise for the treatment of pain in a variety of animal models. However, despite current preclinical evidence supporting the use of CB2 agonists for pain, successful translation of findings from preclinical models to human patients is lacking.
Kelsey G. Guenther, Andrea G. Hohmann
wiley +1 more source
Co-cultured sensory neuron classification using extracellular electrophysiology and machine learning approaches for enhancing analgesic screening. [PDF]
J Neural EngSomers A, Black BJ.
europepmc +1 more source
C‐Nociceptor Activation of Hypothalamic Neurones and the Columnar Organisation of Their Projections to the Periaqueductal Grey in the Rat [PDF]
, 2002 Bridget M. Lumb +4 more
openalex +1 more source
Anti‐nociceptive action of leonurine through TRPA1 and TRPV4 channels modulation
British Journal of Pharmacology, Volume 182, Issue 22, Page 5469-5488, November 2025.Background and Purpose Leonurine, a pseudoalkaloid derived from Leonotis leonurus, has been traditionally used in herbal medicine to alleviate conditions such as headaches and abdominal discomfort. Its therapeutic effects are often attributed to potential antioxidant properties; however, the precise molecular mechanisms remain poorly understood ...
Matilde Marini +20 more
wiley +1 more source
International Endodontic Journal, Volume 58, Issue 11, Page 1681-1710, November 2025.ABSTRACT Background Achieving effective anaesthesia in mandibular molars with symptomatic irreversible pulpitis is challenging. Various strategies involving the inferior alveolar nerve block (IANB) have been investigated, such as supplementing with additional injections after IANB failure (SUPP) or combining injections with IANB as primary injections ...
Thanatpong Rujirawan +2 more
wiley +1 more source
Local Injection of a Selective Endothelin-B Receptor Agonist Inhibits Endothelin-1-Induced Pain-Like Behavior and Excitation of Nociceptors in a Naloxone-Sensitive Manner [PDF]
, 2002 Alla Khodorova +4 more
openalex +1 more source
ChemMedChem, Volume 20, Issue 20, October 15, 2025.Beyond their established role as nonsteroidal anti‐inflammatory drugs (NSAIDs), fenamates (niflumic, flufenamic, mefenamic, meclofenamic, and tolfenamic acids) have recently been identified as modulators of cationic ion channels. This review highlights their differential effects on ion channel activity and explores their potential for repurposing in ...
Paola Laghetti +4 more
wiley +1 more source