Preparation of Specific Nanobodies and Their Application in the Rapid Detection of Nodularin-R in Water Samples [PDF]
Foods, 2021 Nanobodies have several advantages, including great stability, sensibility, and ease of production; therefore, they have become important tools in immunoassays for chemical contaminants.
Jinyi Yang +10 more
doaj +5 more sources
Evaluating the Potential Inhibition of PP2A by Nodularin-R Disinfection By-Products: Effect and Mechanism [PDF]
ToxinsThe secondary contamination of nodularin disinfection by-products (NOD-DBPs) is a problem worthy of attention. In this study, prototypical NOD-R-DBPs were prepared, and their toxicity was assessed using conventional protein phosphatase (PPs) inhibition ...
Mengchen Li +4 more
doaj +3 more sources
Nodularin-R Synergistically Enhances Abiraterone Against Castrate- Resistant Prostate Cancer via PPP1CA Inhibition. [PDF]
J Cell Mol MedABSTRACTClinically, most prostate cancer (PCa) patients inevitably progress to castration‐resistant prostate cancer (CRPC) with poor prognosis after androgen deprivation therapy (ADT), including abiraterone, the drug of choice for ADT. Therefore, it is necessary to explore the resistance mechanism of abiraterone in depth.
Huang Y +8 more
europepmc +4 more sources
Noncompetitive Chromogenic Lateral-Flow Immunoassay for Simultaneous Detection of Microcystins and Nodularin [PDF]
Biosensors, 2019 Cyanobacterial blooms cause local and global health issues by contaminating surface waters. Microcystins and nodularins are cyclic cyanobacterial peptide toxins comprising numerous natural variants.
Sultana Akter +5 more
doaj +3 more sources
LC-MS/MS Analysis of Cyanotoxins in Bivalve Mollusks—Method Development, Validation and First Evidence of Occurrence of Nodularin in Mussels (Mytilus edulis) and Oysters (Magallana gigas) from the West Coast of Sweden [PDF]
Toxins, 2023 In this paper, an LC-MS/MS method for the simultaneous identification and quantification of cyanotoxins with hydrophilic and lipophilic properties in edible bivalves is presented.
Julio César España Amórtegui +6 more
doaj +2 more sources
Production of High Amounts of Hepatotoxin Nodularin and New Protease Inhibitors Pseudospumigins by the Brazilian Benthic Nostoc sp. CENA543 [PDF]
Frontiers in Microbiology, 2017 Nostoc is a cyanobacterial genus, common in soils and a prolific producer of natural products. This research project aimed to explore and characterize Brazilian cyanobacteria for new bioactive compounds.
Jouni Jokela +10 more
doaj +4 more sources
Environmental Advances, 2022 Adsorption mechanisms of individual and collective sorption of microcystins (MCs) and nodularin-R (NOD-R) onto heat-treated rice husk (RH) at neutral pH were evaluated.
Sharmila I. Thenuwara +3 more
doaj +2 more sources
Biotransformation Is an Effective Mechanism for Modulating the Biological Toxicity of Nodularin (NODR) [PDF]
ToxinsThe biotransformation of nodularin (NOD) is one of the critical strategies for regulating their biological toxicity. To investigate the effects and mechanisms of the biotransformation pathway, this study synthesized six biotransformation products of ...
Chunyu Fu +4 more
doaj +2 more sources
Non-competitive ELISA with broad specificity for microcystins and nodularins [PDF]
Advances in Oceanography and Limnology, 2017 Simple and cost-effective methods with sufficient sensitivities for preliminary screening of cyanobacterial toxins are in high demand for assessing water quality and safety.
Sultana Akter +4 more
doaj +3 more sources
Rapid and Highly Sensitive Non-Competitive Immunoassay for Specific Detection of Nodularin [PDF]
Microorganisms, 2017 Nodularin (NOD) is a cyclic penta-peptide hepatotoxin mainly produced by Nodularia spumigena, reported from the brackish water bodies of various parts of the world.
Sultana Akter +3 more
doaj +3 more sources