Results 71 to 80 of about 1,531 (204)

Rekombination hybrider Megasynthasen als Schlüssel für die Evolution metabolischer Diversität in Cyanobakterien

Angewandte Chemie, Volume 137, Issue 26, June 24, 2025.
Natürliche Kombinatorik: Die evolutionäre Rekombination und Anpassung von drei cyanobakteriellen Biosynthese‐Genclustern führte zur Entstehung von Minutumamiden, einer neuen Familie von Peptid‐Polyketid‐Hybriden. Mittels retro‐evolutionärer Analyse gelang die Entdeckung des Nostopeptolids KVJ3, einem evolutionären Vorfahren, der die Biosynthese von ...
Keishi Ishida, Qi Sun, Jonna Teikari, Christian Hertweck, Elke Dittmann, Masahiro Murakami, Martin Baunach   +6 more
wiley   +1 more source

Mixing and Matching of Hybrid Megasynthases is a Hub for the Evolution of Metabolic Diversity in Cyanobacteria

Angewandte Chemie International Edition, Volume 64, Issue 26, June 24, 2025.
Natural combinatorics: Evolutionary mixing and matching of three cyanobacterial biosynthetic gene clusters resulted in the emergence of minutumamides, a novel family of peptide‐polyketide hybrids. Retro‐evolutionary analysis led to the discovery of nostopeptolide KVJ3, an evolutionary ancestor that links nostopeptolide and minutumamide biosynthesis and
Keishi Ishida, Qi Sun, Jonna Teikari, Christian Hertweck, Elke Dittmann, Masahiro Murakami, Martin Baunach   +6 more
wiley   +1 more source

HEK-293T cells expressing OATP1B1/1B3 undergo apoptosis upon nodularin treatment. [PDF]

, 2014
A-D: Confocal micrographs of a HEK-293T cell with enforced expression of OATP1B3. Visualization of OATP1B3 stained green (A), F-actin stained red (B), and composite image (C) of OATP1B3 (green), F-actin (red) and nucleus (blue).
Camilla Krakstad (106761), Knut Teigen (227895), Hanne Hagland (553057), Rune Kleppe (553058), Lars Herfindal (150484), Lene Myhren (148123), Frank Schwede (103997), Stein Ove Døskeland (150491), Reidun Kopperud (175576)   +8 more
core   +1 more source

First Report of the Co-occurrence of Cylindrospermopsin, Nodularin and Microcystins in the Freshwaters of Lake Victoria, Tanzania [PDF]

, 2020
There is a global concern regarding the increase of cyanotoxins in freshwater and their potential effects on human health. The existence of multiple toxins in freshwater can result in an increased risk of their bioaccumulation in humans from their ...
Mchau, GJ, Elliott, CT, Gong, Yun Yun, Elliott, Christopher, Kimanya, M, Elliott, Christopher T., Kimanya, Kimanya, Greer, B, Machunda, Revocatus, Gong, Yun, Machunda, Machunda, Gong 2, Yun, Greer, Brett, Kimanya, Martin, Meneely, Julie P., Makule, Edna, Mpolya, E, Machunda, R, Gong, YY, Meneely, Julie, Makule, E, Mchau, Geofrey J., Mpolya, Emmanuel, Mchau, Geofrey, Meneely, JP   +24 more
core   +1 more source

Pathway for Biodegrading Nodularin (NOD) by Sphingopyxis sp. USTB-05

Toxins, 2016
Nodularin (NOD) is greatly produced by Nodularia spumigena and released into the environment when toxic cyanobacterial blooms happened in natural water body, which is seriously harmful to human and animals.
Nan Feng, Fan Yang, Hai Yan, Chunhua Yin, Xiaolu Liu, Haiyang Zhang, Qianqian Xu, Le Lv, Huasheng Wang   +8 more
doaj   +1 more source

The Great Lakes Winter Grab: Limnological data from a multi‐institutional winter sampling campaign on the Laurentian Great Lakes

Limnology and Oceanography Letters, Volume 10, Issue 1, Page 37-61, February 2025.
Abstract Interest in winter limnology is growing rapidly, but progress is hindered by a shortage of standardized multivariate datasets on winter conditions. Addressing the winter data gap will enhance our understanding of winter ecosystem function and of lake response to environmental change.
Ge Pu, Kirill Shchapov, Nolan J. T. Pearce, Kelly Bowen, Andrew Bramburger, Andrew Camilleri, Hunter Carrick, Justin D. Chaffin, William Cody, Maureen L. Coleman, Warren J. S. Currie, David C. Depew, Jonathan P. Doubek, Rachel Eveleth, Mark Fitzpatrick, Paul W. Glyshaw, Casey M. Godwin, R. Michael McKay, Mohiuddin Munawar, Heather Niblock, Maci Quintanilla, Michael Rennie, Matthew W. Sand, Kimberly J. Schraitle, Michael R. Twiss, Donald G. Uzarski, Henry A. Vanderploeg, Trista J. Vick‐Majors, Judy A. Westrick, Bridget A. Wheelock, Marguerite A. Xenopoulos, Arthur Zastepa, Ted Ozersky   +32 more
wiley   +1 more source

Synthesis of cyclic peptides modelled on the microcystin and nodularin rings [PDF]

, 1996
Several precursor cyclic peptides modelled on the ring systems of microcystin-LR and nodularin were synthesized. Synthesis was best achieved using solid-phase cyclization with solution-phase methods being successful in only one instance.
Alewood, Paul, Quinn, Ronald J., Taylor, Cherie   +2 more
core   +1 more source

Mechanisms of Pesticide Toxicity in Fish: Insights Into the Ameliorative Role of Plant‐Derived Compounds—A Review

Aquaculture Nutrition, Volume 2025, Issue 1, 2025.
Pesticide contamination in aquatic environments poses severe risks to fish health, causing oxidative stress, immunosuppression, endocrine disruption, and neurotoxicity. These effects result from the accumulation of reactive oxygen species (ROSs), enzyme inhibition, and damage to physiological systems. Plant‐derived compounds and phytochemicals, such as
Sayyed Ali Moezzi, Sudabe Ramezani, Kiadokht Rezaei, Arash Javanshir Khoei, Noah Esmaeili   +4 more
wiley   +1 more source

Comparative effects of nodularin and microcystin-LR in zebrafish: 2. Uptake and molecular effects in eleuthero-embryos and adult liver with focus on endoplasmic reticulum stress [PDF]

, 2016
Microcystin (MC) and nodularin are structurally similar cyanobacterial toxins that inhibit protein phosphatases. Additional modes of action are poorly known, in particular for nodularin.
Karl Fent, Pernthaler, Jakob, Faltermann, Susanne, Grundler, Verena, Karl Gademann, Gademann, Karl, Susanne Faltermann, Fent, Karl, Verena Grundler, Jakob Pernthaler   +9 more
core   +1 more source

Effects of Seasonal Dynamics on Cyanobacteria Proliferation in Aquaculture Fish Ponds

Aquaculture Research, Volume 2025, Issue 1, 2025.
Aquaculture production supports the United Nations Sustainable Development Goals (SDGs), especially SDG 2 (Zero Hunger), by enhancing food security and sustainable practices. This study investigated the seasonal dynamics of cyanobacterial (CB) blooms in aquaculture fishponds in South Africa (SA) and Nigeria (NGA). Water samples were collected twice per
Odo J. Bassey, Jabulani R. Gumbo, Mulalo I. Mutoti   +2 more
wiley   +1 more source