Results 81 to 90 of about 1,721 (197)

Single domain antibody: Development and application in biotechnology and biopharma

Immunological Reviews, Volume 328, Issue 1, Page 98-112, November 2024.
Summary Heavy‐chain antibodies (HCAbs) are a unique type of antibodies devoid of light chains, and comprised of two heavy chains‐only that recognize their cognate antigen by virtue of a single variable domain also referred to as VHH, single domain antibody (sdAb), or nanobody (Nb).
Ting Yu, Fang Zheng, Wenbo He, Serge Muyldermans, Yurong Wen   +4 more
wiley   +1 more source

First Report of the Co-occurrence of Cylindrospermopsin, Nodularin and Microcystins in the Freshwaters of Lake Victoria, Tanzania [PDF]

, 2020
There is a global concern regarding the increase of cyanotoxins in freshwater and their potential effects on human health. The existence of multiple toxins in freshwater can result in an increased risk of their bioaccumulation in humans from their ...
Mchau, GJ, Elliott, CT, Gong, Yun Yun, Elliott, Christopher, Kimanya, M, Elliott, Christopher T., Kimanya, Kimanya, Greer, B, Machunda, Revocatus, Gong, Yun, Machunda, Machunda, Gong 2, Yun, Greer, Brett, Kimanya, Martin, Meneely, Julie P., Makule, Edna, Mpolya, E, Machunda, R, Gong, YY, Meneely, Julie, Makule, E, Mchau, Geofrey J., Mpolya, Emmanuel, Mchau, Geofrey, Meneely, JP   +24 more
core   +1 more source

Variable Cyanobacterial Toxin and Metabolite  Profiles across Six Eutrophic Lakes of Differing  Physiochemical Characteristics

Toxins, 2017
Future sustainability of freshwater resources is seriously threatened due to the presence of harmful cyanobacterial blooms, and yet, the number, extent, and distribution of most cyanobacterial toxins—including “emerging” toxins and other bioactive ...
Lucas J. Beversdorf, Chelsea A. Weirich, Sarah L. Bartlett, Todd. R. Miller   +3 more
doaj   +1 more source

Underway measurement of cyanobacterial microcystins using a surface plasmon resonance sensor on an autonomous underwater vehicle

Limnology and Oceanography: Methods, Volume 22, Issue 9, Page 681-699, September 2024.
Abstract Freshwater cyanobacterial harmful algal blooms (CHABs) are a well‐known global public health threat. Monitoring and early detection of CHAB toxins are currently accomplished using labor‐intensive sampling techniques and subsequent shore‐based analyses, with results typically reported 24–48 h after sample collection.
William Ussler III, Gregory J. Doucette, Christina M. Preston, Chloe Weinstock, Nadia Allaf, Brent Roman, Scott Jensen, Kevan Yamahara, Louise A. Lingerfelt, Christina M. Mikulski, Brett W. Hobson, Brian Kieft, Ben‐Yair Raanan, Yanwu Zhang, Reagan M. Errera, Steven A. Ruberg, Paul A. Den Uyl, Kelly D. Goodwin, Scott D. Soelberg, Clement E. Furlong, James M. Birch, Christopher A. Scholin   +21 more
wiley   +1 more source

Molecular detection of hepatotoxic cyanobacteria in inland water bodies of the Marmara Region, Turkey

Advances in Oceanography and Limnology, 2017
Blooms of cyanobacteria are an increasingly frequent phenomenon in freshwater ecosystems worldwide as a result of eutrophication. Many species can produce hepatotoxins that cause severe health hazards to humans.
Latife Köker, Reyhan Akçaalan, Meriç Albay, Brett A. Neilan   +3 more
doaj   +1 more source

Marked inhibition of testosterone biosynthesis by the hepatotoxin nodularin due to apoptosis of Leydig cells.

, 2002
We previously observed that the serum testosterone level was greatly reduced in the course of diethylnitrosamine-nodularin-induced hepatocarcinogenesis in Fischer 344 male rats (Lim et al., Gastroenterological Carcinogenesis, 1999).
Sohn, SH, Lim, IK, Song, KY, Park, TJ
core   +1 more source

Photocatalytic degradation of eleven microcystin analogues and nodularin by TiO2 coated glass microspheres [PDF]

, 2015
Microcystins and nodularin are toxic cyanobacterial secondary metabolites produced by cyanobacteria that pose a threat to human health in drinking water. Conventional water treatment methods often fail to remove these toxins. Advanced oxidation processes
Pestana, Carlos J., Prabhu, Radhakrishna, Lawton, Linda A., Robertson, Peter K. J.; id_orcid, Robertson, Peter K.J., Edwards, Christine   +5 more
core   +1 more source

Nodularin induces tumor necrosis factor-alpha and mitogen-activated protein kinases (MAPK) and leads to induction of endoplasmic reticulum stress

, 2016
Nodularin is produced by the cyanobacterium Nodularia spumigena. It is of concern due to hepatotoxicity in humans and animals. Here we investigated unexplored molecular mechanisms by transcription analysis in human liver cells, focusing on induction of
Meili, Nicole, Fent, Karl, Christen, Verena   +2 more
core   +1 more source

Comparative effects of nodularin and microcystin-LR in zebrafish: 1. Uptake by organic anion transporting polypeptide Oatp1d1 (Slco1d1)

, 2016
Microcystin-LR (MC-LR) and nodularin are hepatotoxins produced by several cyanobacterial species. Their toxicity is based on active cellular uptake and subsequent inhibition of protein phosphatases PP1/2A, leading to hyperphosphorylation and cell death ...
Karl Fent, Pernthaler, Jakob, Faltermann, Susanne, Susanne Faltermann, Prétôt, René, Fent, Karl, René Prétôt, Jakob Pernthaler   +7 more
core   +1 more source

Toxic cyanobacteria blooms in the Lithuanian part of the Curonian Lagoon

Oceanologia, 2009
The phenomenon of cyanobacteria (blue-green algae) blooms in the Baltic and the surrounding freshwater bodies has been known for several decades.
Artūras Razinkovas, Aistė Paldavičienė, Hanna Mazur-Marzec   +2 more
doaj