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Purification and Mechanism of Microcystinase MlrC for Catalyzing Linearized Cyanobacterial Hepatotoxins Using Sphingopyxis sp. USTB-05 [PDF]
Toxins, 2022 Cyanobacterial hepatotoxins, including microcystins (MCs) and nodularins (NODs), are widely produced, distributed and extremely hazardous to human beings and the environment.
Qianwen Zou +9 more
doaj +3 more sources
A HepG2 Cell-Based Biosensor That Uses Stainless Steel Electrodes for Hepatotoxin Detection [PDF]
Biosensors, 2022 Humans are frequently exposed to environmental hepatotoxins, which can lead to liver failure. Biosensors may be the best candidate for the detection of hepatotoxins because of their high sensitivity and specificity, convenience, time-saving, low cost ...
Amirhossein Pakseresht +2 more
exaly +5 more sources
Microorganisms, 2022 (1) Background: Cyanobacteria produce a wide range of secondary metabolites, including tumor-promoting hepatotoxins. We recently reported evidence of an independent association between oral cyanobacteria and hepatocellular carcinoma in a U.S. population.
Brenda Y. Hernandez +6 more
doaj +2 more sources
Acute liver injury is triggered by dysbiosis and microbial translocation involving gut–liver axis [PDF]
Gut MicrobesAcute liver injury (ALI) is a severe clinical condition that can progress to chronic liver failure, cirrhosis, or hepatocellular carcinoma, yet therapeutic options remain limited.
Urmi Halder +6 more
doaj +2 more sources
Genomic Analysis of Sphingopyxis sp. USTB-05 for Biodegrading Cyanobacterial Hepatotoxins
Toxins, 2022 Sphingopyxis sp. USTB-05, which we previously identified and examined, is a well-known bacterial strain for biodegrading cyanobacterial hepatotoxins of both nodularins (NODs) and microcystins (MCs).
Chao Liu +7 more
doaj +2 more sources
Hepatoprotective activities of polyherbal formulations: A systematic review
Journal of Medicinal Plants for Economic Development, 2023 Background: Liver diseases pose a substantial global public health challenge, encompassing conditions such as liver failure, hepatitis, cirrhosis and associated complications Safeguarding the liver becomes important as these conditions impact human ...
Elizabeth B. Aladejana +1 more
doaj +1 more source
Frontiers in Microbiology, 2021 Toxin-producing cyanobacteria can be harmful to aquatic biota, although some grazers utilize them with often beneficial effects on their growth and reproduction. It is commonly assumed that gut microbiota facilitates host adaptation to the diet; however,
Elena Gorokhova +3 more
doaj +1 more source
International Journal of Research in Pharmaceutical Sciences, 2021 The objective of this research was to see whether the ethanolic extract of Artabotrys hexapetalus leaves had antioxidant and hepatoprotective properties against paracetamol (PCT), ethanol (ETN), and isoniazid and rifampicin (IR)-induced hepatotoxicity in
Suresh K +2 more
doaj +1 more source
Impaired hepatic autophagy exacerbates hepatotoxin induced liver injury
Cell Death Discovery, 2023 Hepatotoxins activate the hepatic survival pathway, but it is unclear whether impaired survival pathways contribute to liver injury caused by hepatotoxins.
Katherine Byrnes +9 more
doaj +1 more source
Sedimentation Patterns of Toxin-Producing Microcystis Morphospecies in Freshwater Reservoirs
Toxins, 2013 Understanding the annual cycle of Microcystis is essential for managing the blooms of this toxic cyanobacterium. The current work investigated the sedimentation of microcystin-producing Microcystis spp.
Antonio Quesada +3 more
doaj +1 more source