Results 21 to 30 of about 4,323 (190)

Metabolic Hijacking of Hexose Metabolism to Ascorbate Synthesis Is the Unifying Biochemical Basis of Murine Liver Fibrosis

open access: yesCells, 2023
We wished to understand the metabolic reprogramming underlying liver fibrosis progression in mice. Administration to male C57BL/6J mice of the hepatotoxins carbon tetrachloride (CCl4), thioacetamide (TAA), or a 60% high-fat diet, choline-deficient, amino-
Diren Beyoğlu   +5 more
doaj   +1 more source

Biostatistical Analysis on Synergetic therapy of the three plants

open access: yesInternational Journal of Medical Sciences and Academic Research, 2023
The liver is an important metabolic organ consisting of four different sized lobes in our bodies. Theimportant function of liver includes the elimination of toxic material, detoxication and regulationof theblood, blood clotting, and manufacture of vital ...
Dr. Bin Zhao
doaj   +1 more source

Reference genes for real-time PCR quantification of microRNAs and messenger RNAs in rat models of hepatotoxicity. [PDF]

open access: yesPLoS ONE, 2012
Hepatotoxicity is associated with major changes in liver gene expression induced by xenobiotic exposure. Understanding the underlying mechanisms is critical for its clinical diagnosis and treatment.
María N Lardizábal   +5 more
doaj   +1 more source

Impact of Cyanotoxin Ingestion on Liver Cancer Development Using an At-Risk Two-Staged Model of Mouse Hepatocarcinogenesis

open access: yesToxins, 2022
Exposure to cyanobacterial hepatotoxins has been linked to the promotion and increased incidence of liver cancer in pre-clinical and epidemiologic studies.
Igor Mrdjen   +3 more
doaj   +1 more source

Proteomic responses of HepG2 cell monolayers and 3D spheroids to selected hepatotoxins [PDF]

open access: yes, 2019
Despite the importance of hepatotoxicity testing in the development of new potential pharmaceuticals, standardized methods for preclinical in vitro hepatotoxicity is complicated by the perceived adequacy of approach, diversity of origin of cells, and the
Hurrell, Tracey   +2 more
core   +1 more source

Transcription regulation of hepatotoxins microcystin and nodularin from cyanobacteria [PDF]

open access: yes, 2008
The role and function of hepatotoxins microcystin and nodularin produced by M.aeruginosa PCC 7806 and N. spumigena NSORlO respectively have yet to be elucidated.
Root, Hannah Patricia
core   +1 more source

Bacteria homologus to Aeromonas capable of microcystin degradation

open access: yesOpen Life Sciences, 2015
Water blooms dominated by cyanobacteria are capable of producing hepatotoxins known as microcystins. These toxins are dangerous to people and to the environment.
Mankiewicz-Boczek J.   +5 more
doaj   +1 more source

Chemical Study of the Hepatotoxins from Microcystis Aeruginosa Collected in California

open access: yes, 1993
Four cyclic peptide toxins were purified and quantified from the aqueous extract of algal cell material utilizing high performance liquid chromatography, thin layer chromatography, and fast atom bombardment mass spectrometry.
F. D. Galey   +5 more
core   +1 more source

Can a one-sampling campaign produce robust results for water quality monitoring? A case of study in Itupararanga reservoir, SP, Brazil

open access: yesActa Limnologica Brasiliensia
Aim: The aim of this study was to conduct a rapid and comprehensive analysis of the reservoir using physical, chemical and biological variables comprising water and sediment as also to verify if a one-sampling campaign can produce information that is ...
Frederico Guilherme de Souza Beghelli   +5 more
doaj   +1 more source

Experimental models used for the study of antihepatotoxic agents

open access: yesJournal of Acute Disease, 2012
Both in vitro and in vivo liver models have been developed in the past years to study the hepatoprotective agents. These systems measure the ability of the test drug to prevent or cure liver toxicity (induced by various hepatotoxins) in experimental ...
Feroz Ahmad, Nahida Tabassum
doaj   +1 more source

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