Results 51 to 60 of about 326,550 (312)

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

Pharmacological effects of osimertinib on a chicken chorioallantoic membrane xenograft model with the EGFR exon‐19‐deleted advanced NSCLC mutation

FEBS Open Bio, EarlyView.
Osimertinib reduces angiogenesis and PDL1 expression in in ovo tumors, transforming them into ‘cold tumors’ with lower immune activity. Anatomopathological and transcriptomic analyses highlight its therapeutic impact on tumor biology. This study underscores osimertinib's potential to reshape the tumor microenvironment and provides insights into its ...
David Barthélémy, Arnaud Vigneron, Xavier Rousset, Jérome Guitton, Emmanuel Grolleau, Margaux Raffin, Julie Balandier, Gaëlle Lescuyer, Mathilde Bardou, Florence Geiguer, Sébastien Couraud, Claire Bardel, Jean Viallet, Nazim Benzerdjeb, Léa Payen   +14 more
wiley   +1 more source

Noise reduction algorithm for glueball correlators

Physics Letters B, 2014
We present an error reduction method for obtaining glueball correlators from Monte Carlo simulations of SU(3) lattice gauge theory. We explore the scalar and tensor channels at three different lattice spacings.
Pushan Majumdar, Nilmani Mathur, Sourav Mondal   +2 more
doaj   +1 more source

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

FEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi, Xin Gao, Takashi Gojobori   +2 more
wiley   +1 more source

"Aging behavior of fluororubber with high fluorine content in aviation lubricating oil"

Hecheng xiangjiao gongye
High fluorine content fluororubber (FKM) was used as the research object, the high temperature medium resistance of high fluorine content FKM vulcanizates in a variety of aero-engine lubricanting oils was investigated, and the changes in physical and ...
SONG Rong-hao, YANG Rui, WANG Chen, SU Zheng-tao
doaj   +1 more source

THE IMPACT ANALYSIS OF THE NOISE SCREENS ON THE EXAMPLE OF A TRANSPORT INTERCHANGE IN THE CITY OF OMSK

Вестник СибАДИ, 2020
Introduction. Noise pollution is one of the three most significant environmental disruptions in the world. In urban areas, the main source of noise is road transport, which accounts up to 80% of all noise.
D. A. Shevelev, V. V. Sirotiuk, E. A. Gerashchenko, E. A. Stepanova   +3 more
doaj   +1 more source

Noise reduction method for wire rope damage signal under strong noise background

Gong-kuang zidonghua, 2022
The wire rope damage signal is a kind of non-stationary and non-periodic impact signal, and the noise reduction processing and characteristic extraction of its characteristic signal become difficult problems to be solved urgently.
WU Dong, ZHANG Baojin, LIU Weixin, LI Guang, GONG Tao, YANG Jianhua   +5 more
doaj   +1 more source

Long non‐coding RNAs as therapeutic targets in head and neck squamous cell carcinoma and clinical application

FEBS Open Bio, EarlyView.
Long non‐coding RNAs (lncRNAs) occupy an abundant fraction of the eukaryotic transcriptome and an emerging area in cancer research. Regulation by lncRNAs is based on their subcellular localization in HNSCC. This cartoon shows the various functions of lncRNAs in HNSCC discussed in this review.
Ellen T. Tran, Ruchi A. Patel, Amogh Chariyamane, Ratna B. Ray   +3 more
wiley   +1 more source

Noise Reduction Potential of Cellular Metals

Metals, 2012
Rising numbers of flights and aircrafts cause increasing aircraft noise, resulting in the development of various approaches to change this trend. One approach is the application of metallic liners in the hot gas path of aero-engines.
Björn Hinze, Joachim Rösler, Nicolas Lippitz   +2 more
doaj   +1 more source

Noise reduction on mammographic phantom images

ELCVIA Electronic Letters on Computer Vision and Image Analysis, 2006
A noise reduction scheme on digitized mammographic phantom images is presented. This algorithm is based on a direct contrast modification method with an optimal function, obtained by using the mean squared error as a criterion.
Mouloud Adel, Daniel Zuwala, Monique Rasigni, Salah Bourennane   +3 more
doaj   +1 more source