Results 51 to 60 of about 4,484,233 (290)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Perceptual effects of noise mitigation

, 2014
Noise mitigation reduces the audibility of a noise source at the location of the receiver, making the source less annoying and less likely to interfere with activities, such as sleep, rest, and speech. Many mitigation methods change temporal and spectral
Nilsson, Mats E.,, Jeon, Jin Yong, Rådsten Ekman, Maria,, Botteldooren, Dick, Vincent, Bruno, Maillard, Julien, De Coensel, Bert, Joo, Young Hong   +7 more
core   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Noise reduction mechanisms of active noise barriers [PDF]

, 2013
The sound field and acoustic power flow from different regions around an active noise barrier are analyzed using a two-dimensional numerical model. Results show that the noise reduction of the active noise barrier can be described as a combination of ...
Qiu, X, Chen, Weisong, Min, Hequn, Qiu, Xiaojun, Min, H, Chen, W   +5 more
core   +1 more source

Cortical and Subjective Measures of Individual Noise Tolerance Predict Hearing Outcomes with Varying Noise Reduction Strength

Applied Sciences
Noise reduction (NR) algorithms are employed in nearly all commercially available hearing aids to attenuate background noise. However, NR processing also involves undesirable speech distortions, leading to variability in hearing outcomes among ...
Subong Kim, Susan Arzac, Natalie Dokic, Jenn Donnelly, Nicole Genser, Kristen Nortwich, Alexis Rooney   +6 more
doaj   +1 more source

Noise Reduction in a Reputation Index

International Journal of Financial Studies, 2018
Assuming that a time series incorporates “signal” and “noise” components, we propose a method to estimate the extent of the “noise” component by considering the smoothing properties of the state-space of the time series. A mild degree of smoothing in the
Peter Mitic
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Turbulence-airfoil interaction noise reduction using wavy leading edge: an experimental and numerical study

, 2011
International audiencePassive treatments aiming at reducing turbofan broadband noise have been recently studied in the framework of European Project FLOCON.
Clair, Vincent, Polacsek, Cyril, Reboul, Gabriel, Deniau, Hugues   +3 more
core   +6 more sources

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source