Results 181 to 190 of about 130,883 (345)

Conditional Versus Unconditional Covariate Effects in Pharmacometric Models: Implications for Interpretation, Communication, and Reporting

open access: yesCPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 2, February 2026.
ABSTRACT This work investigates how correlations between covariates influence the estimation of their effects in pharmacometric models. The focus is on quantifying the impact on conditional and unconditional covariate effect estimates and assessing the consequences for model interpretation, communication, and dosing recommendations.
E. Niclas Jonsson   +3 more
wiley   +1 more source

Correlation of unfavourable and favourable histology at radical prostatectomy with Decipher scores and freedom from biochemical recurrence

open access: yesHistopathology, Volume 88, Issue 3, Page 605-614, February 2026.
A recent study proposed a system of unfavourable and favourable histology categories to risk‐stratify prostate cancer patients. In a study of radical prostatectomy cases which had Decipher molecular classifier testing, unfavourable histology was associated with higher Decipher scores, increased biochemical recurrence (BCR) risk and improved BCR ...
Nancy Y Greenland   +9 more
wiley   +1 more source

External Validation of a Clinical Prediction Tool for the Use of Manual Therapy in Patients With Temporomandibular Disorders

open access: yesJournal of Oral Rehabilitation, Volume 53, Issue 2, Page 515-528, February 2026.
Predicting the response to manual therapy for people with temporomandibular disorders. ABSTRACT Background Manual therapy (MT) is frequently used to manage temporomandibular disorders (TMDs), yet patient responses vary significantly. Predictive models may help clinicians tailor treatments to individual patients. Objectives The primary aim of this study
G. Asquini   +7 more
wiley   +1 more source

Mining Potential Therapeutic Targets for T Cell Exhaustion in Osteoarthritis by Integrating Mendelian Randomization and Single‐Cell Sequencing

open access: yesThe FASEB Journal, Volume 40, Issue 2, 31 January 2026.
This study conducted an integrated analysis using multi‐source data, with specific data sources including the GEO database (encompassing datasets GSE55235, GSE55457, and GSE152805), literature‐mined gene sets, and the IEU OpenGWAS database (dataset ebi‐a‐GCST005814).
Jiahong Li   +9 more
wiley   +1 more source

In Situ Assembly of Transformable Monopeptide on Activated Neutrophils Attenuates NETs‐Induced Hepatocellular Carcinoma Metastasis by Disrupting NE Nuclear Translocation

open access: yesAdvanced Science, Volume 13, Issue 1, 5 January 2026.
Activated neutrophils release extracellular traps (NETs) that promote tumor metastasis. FTP‐NPs are develpoed, a peptidic nanomaterial that binds NE on neutrophil membranes, forming NE‐fibril clusters that deactivate NE and prevent NETs formation. This strategy reduces metastasis and enhances the anti‐tumor immune response by targeting NE subcellular ...
Yichi Chen   +13 more
wiley   +1 more source

Home - About - Disclaimer - Privacy