Diagnostic Accuracy Studies: Sensitivity, Specificity, and Beyond
This methodological article covers key diagnostic accuracy measures, common pitfalls in diagnostic accuracy studies, and how evidence should progress from diagnostic accuracy to clinical effectiveness, with examples from various fields. ABSTRACT Diagnostic tests are central to medical care, and their evaluation remains methodologically challenging ...
Nancy Vegas +2 more
wiley +1 more source
Modeling survival prognosis in female patients with bone metastases from lung adenocarcinoma: A retrospective study based on the SEER database and a Chinese cohort. [PDF]
Li Z, Zhou Z, Chen X, Niu S.
europepmc +1 more source
Abstract Background Periodontal clinical trials commonly use surrogate end points (e.g., probing pocket depth [PPD], clinical attachment level [CAL], bleeding on probing [BoP], and composite scores such as the Periodontal Risk Score [PRS]) for efficiency, yet tooth loss, treatment burden/cost, and re‐treatment are the definitive patient‐relevant ...
Muhammad H. A. Saleh +7 more
wiley +1 more source
Development and Internal Validation of a Web-Based Dynamic Nomogram for Dynamic Risk Stratification of Early Bacterial Infection in Liver Transplant Recipients. [PDF]
Ngo TD +7 more
europepmc +1 more source
What's New? Using 21 SNPs, two novel PRS were constructed and used to develop two new machine‐learning classifiers, one for the detection of prostate cancer and the other for the prediction of its aggressiveness and subsequent mortality. The classifier for disease detection is built using the PRS as the sole feature, whereas the one for disease ...
Leandro Rodrigues Santiago +3 more
wiley +1 more source
Reply to Asim Armagan Aydin, Erkan Kayikcioglu, and Ramazan Oguz Yuceer's Letter to the Editor re: Muhammet Demirbilek, Göktuğ Kalender, Said Bıyıkoglu, et al. External Validation of Nomograms for Predicting Pelvic Lymph Node Metastases in Patients with Prostate Cancer and the Added Value of the Prostate-specific Membrane Antigen Positron Emission Tomography-based PRIMARY Score. Eur Urol Open Sci 2025;82:170-7. [PDF]
Önal B, Demirbilek M, Kabasakal L.
europepmc +1 more source
ABSTRACT Aim To evaluate whether preoperative prognostic nutritional index (PNI) values predict prolonged postoperative hospital stay in patients with oral cancer undergoing highly invasive surgery. Methods We retrospectively evaluated background factors (age, sex, primary site, preoperative clinical stage, type of free flap, and the PNI) and ...
Go Ohara +6 more
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Development and external validation of nomograms for predicting prostate cancer and clinically significant prostate cancer in patients with PSA between 4 and 20 ng/mL. [PDF]
Wu K +7 more
europepmc +1 more source
ABSTRACT Background Patients with acute myeloid leukemia (AML) experience severe infections frequently during and after chemotherapy. The purpose of this study was to develop an early risk assessment tool to identify newly diagnosed AML patients at high risk of developing sepsis during the early phase of induction chemotherapy.
Cui‐Ying Gu +4 more
wiley +1 more source

