Results 11 to 20 of about 524,132 (248)

Adjuvant-containing control arms in pivotal quadrivalent human papillomavirus vaccine trials: Restoration of previously unpublished methodology [PDF]

, 2020
Purpose: Trustworthy reporting of quadrivalent human papillomavirus (HPV) vaccine trials is the foundation for assessing the vaccine's risks and benefits.
Bourgeois, Florence, Doshi, Peter, Hong, Kyungwan, Jefferson, Tom, Jones, Mark, Lee, Haeyoung, Shamseer, Larissa, Spence, O'Mareen   +7 more
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Regulatory Evolution of Neonicotinoid Insecticides as Plant Protection Active Substances in Europe

Agrochemicals, 2023
Neonicotinoid (NN) insecticides derived from natural insecticide nicotine are EU chemical crop protection systemic active substances that are controversial regarding their toxicity and ecotoxicity, especially versus pollinators and birds.
Patrice A. Marchand
doaj   +1 more source

Basic substances under EC 1107/2009 phytochemical regulation: experience with non-biocide and food products as biorationals

Journal of Plant Protection Research, 2016
Basic Substances are a newly effective category of Plant Protection Product under EC Regulation No 1107/2009. The first approved application of Equisetum arvense L.
Marchand Patrice A.
doaj   +1 more source

Neuromodulatory treatments for psychiatric disease: A comprehensive survey of the clinical trial landscape

Brain Stimulation, 2021
Background: Numerous neuromodulatory therapies are currently under investigation or in clinical use for the treatment of psychiatric conditions.
Gavin J.B. Elias, Alexandre Boutet, Roohie Parmar, Emily H.Y. Wong, Jürgen Germann, Aaron Loh, Michelle Paff, Aditya Pancholi, Dave Gwun, Clement T. Chow, Flavia Venetucci Gouveia, Irene E. Harmsen, Michelle E. Beyn, Emiliano Santarnecchi, Alfonso Fasano, Daniel M. Blumberger, Sidney H. Kennedy, Andres M. Lozano, Venkat Bhat   +18 more
doaj   +1 more source

Scientific Opinion on the safety evaluation of the active substance iron (II) modified bentonite as oxygen absorber for use in active food contact materials [PDF]

EFSA Journal, 2012
<p>This scientific opinion of EFSA deals with the safety evaluation of the active substance iron (II) modified bentonite (FCM Substance No 1003) intended to be incorporated in monolayer or multilayer packages or in sachets for absorbing oxygen from
EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF)
doaj   +1 more source

Biological screening of a unique drug library targeting MRGPRX2

Frontiers in Immunology, 2022
BackgroundAllergic drug reaction or drug allergy is an immunologically mediated drug hypersensitivity reaction (DHR). G-protein coupled receptors (GPCRs) are common drug targets and communicate extracellular signals that initiate cellular responses ...
Fan Yang, Fan Yang, Nathachit Limjunyawong, Qi Peng, John T. Schroeder, Sarbjit Saini, Donald MacGlashan, Xinzhong Dong, Li Gao   +8 more
doaj   +1 more source

Selective review and commentary on emerging pharmacotherapies for opioid addiction. [PDF]

, 2011
Pharmacotherapies for opioid addiction under active development in the US include lofexidine (primarily for managing withdrawal symptoms) and Probuphine®, a distinctive mode of delivering buprenorphine for six months, thus relieving patients, clinicians,
Ling, Walter, Miotto, Karen, Mooney, Larissa, Nielsen, Suzanne, Torrington, Matthew, Zhao, Min   +5 more
core   +2 more sources

Unapproved clinical trials in Russia: exception or norm?

BMC Medical Ethics, 2021
Background In modern Russia, any clinical investigation of a pharmaceutical for use in humans is subject to prior evaluation and approval by the Ministry of Health and its Central Ethics Committee.
Petr Talantov, Ravil Niyazov, Galina Viryasova, Margarita Dranitsyna, Ilya Yasny   +4 more
doaj   +1 more source

Photodegradation of Bexarotene and Its Implication for Cytotoxicity

Pharmaceutics, 2021
A detailed understanding of the stability of an active pharmaceutical ingredient and a pharmaceutical dosage form is essential for the drug-development process and for safe and effective use of medicines.
Agata Kryczyk-Poprawa, István Zupkó, Péter Bérdi, Paweł Żmudzki, Joanna Piotrowska, Elżbieta Pękala, Aleksandra Berdys, Bożena Muszyńska, Włodzimierz Opoka   +8 more
doaj   +1 more source

Successful private–public funding of paediatric medicines research: lessons from the EU programme to fund research into off-patent medicines [PDF]

, 2014
The European Paediatric Regulation mandated the European Commission to fund research on off-patent medicines with demonstrated therapeutic interest for children.
Baiardi, P, Bonifazi, D, Bonifazi, F, Ceci, A, Chiron, C, Davies, E H, Eichler, I, Felisi, M, Giannuzzi, V, Giaquinto, C, Jacqz-Aigrain, E, Neubert, A, on behalf of the GRiP Consortium,, Pressler, R, Rabe, H, Ruggieri, L, Turner, M A, Whitaker, M J   +17 more
core   +1 more source