Results 11 to 20 of about 134,017 (204)

Basic Substances and Potential Basic Substances: Key Compounds for a Sustainable Management of Seedborne Pathogens

open access: yesHorticulturae, 2023
Seedborne pathogens represent a critical issue for successful agricultural production worldwide. Seed treatment with plant protection products constitutes one of the first options useful for reducing seed infection or contamination and preventing disease
Laura Orzali   +6 more
doaj   +1 more source

Regulatory Evolution of Neonicotinoid Insecticides as Plant Protection Active Substances in Europe

open access: yesAgrochemicals, 2023
Neonicotinoid (NN) insecticides derived from natural insecticide nicotine are EU chemical crop protection systemic active substances that are controversial regarding their toxicity and ecotoxicity, especially versus pollinators and birds.
Patrice A. Marchand
doaj   +1 more source

Basic substances under EC 1107/2009 phytochemical regulation: experience with non-biocide and food products as biorationals

open access: yesJournal of Plant Protection Research, 2016
Basic Substances are a newly effective category of Plant Protection Product under EC Regulation No 1107/2009. The first approved application of Equisetum arvense L.
Marchand Patrice A.
doaj   +1 more source

Neuromodulatory treatments for psychiatric disease: A comprehensive survey of the clinical trial landscape

open access: yesBrain Stimulation, 2021
Background: Numerous neuromodulatory therapies are currently under investigation or in clinical use for the treatment of psychiatric conditions.
Gavin J.B. Elias   +18 more
doaj   +1 more source

Biological screening of a unique drug library targeting MRGPRX2

open access: yesFrontiers in Immunology, 2022
BackgroundAllergic drug reaction or drug allergy is an immunologically mediated drug hypersensitivity reaction (DHR). G-protein coupled receptors (GPCRs) are common drug targets and communicate extracellular signals that initiate cellular responses ...
Fan Yang   +8 more
doaj   +1 more source

Unapproved clinical trials in Russia: exception or norm?

open access: yesBMC Medical Ethics, 2021
Background In modern Russia, any clinical investigation of a pharmaceutical for use in humans is subject to prior evaluation and approval by the Ministry of Health and its Central Ethics Committee.
Petr Talantov   +4 more
doaj   +1 more source

Photodegradation of Bexarotene and Its Implication for Cytotoxicity

open access: yesPharmaceutics, 2021
A detailed understanding of the stability of an active pharmaceutical ingredient and a pharmaceutical dosage form is essential for the drug-development process and for safe and effective use of medicines.
Agata Kryczyk-Poprawa   +8 more
doaj   +1 more source

Methodology of the Development of a Topical Transdermal Fucoidan Delivery System

open access: yesРазработка и регистрация лекарственных средств, 2023
Introduction. Marine-derived polysaccharides are promising candidates for the development of innovative drugs. One of such compounds is the polysaccharide fucoidan from brown seaweeds, which shows anticoagulant and anti-inflammatory activity.
E. D. Obluchinskaya   +2 more
doaj   +1 more source

The Role of Early Maladaptive Schemas and Coping Strategies in Substance Dependency

open access: yesBilişsel Davranışçı Psikoterapi ve Araştırmalar Dergisi, 2014
Objective: The aim of this study was to evaluate the early maladaptive schemas and coping strategies of substance dependents. We hypothesized that substance dependents would have more maladaptive unhealthy schemas and would use less adaptive coping ...
Bikem Haciomeroglu   +4 more
doaj   +1 more source

Intravenous Tramadol is Effective in the Management of Postoperative Pain Following Abdominoplasty: A Three-Arm Randomized Placebo- and Active-Controlled Trial

open access: yesDrugs in R&D, 2020
Background and Objective Oral tramadol, an atypical opioid approved in the United States (US) since 1995 and a Schedule IV controlled substance, has less abuse liability compared to Schedule II conventional opioids.
Harold Minkowitz   +8 more
doaj   +1 more source

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