Results 51 to 60 of about 13,542,190 (238)

3447 Effects of intranasal ketamine on uncontrolled cancer related pain

Journal of Clinical and Translational Science, 2019
OBJECTIVES/SPECIFIC AIMS: If intranasal ketamine can be utilized for pain control in cancer patients, this could provide them with superior analgesia and better quality of life, without the risk of significant respiratory depression associated with ...
Vinita Singh, Donald Harvey
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Setting of residue definitions and toxicological reference values for ethiprole

EFSA Journal
In accordance with Article 6 of Regulation (EC) No 396/2005, the original evaluating Member State (EMS), the United Kingdom, received an application from Bayer CropScience to set an import tolerance for the non‐approved active substance ethiprole in rice.
European Food Safety Authority (EFSA), Sofia Batista Leite, Giulia Bellisai, Giovanni Bernasconi, Marco Binaglia, Luis Carrasco Cabrera, Irene Castellan, Anna Federica Castoldi, Arianna Chiusolo, Mathilde Colas, Federica Crivellente, Monica Del Aguila, Lucien Ferreira, Monica Fittipaldi Broussarad, Luna Greco, Frederique Istace, Samira Jarrah, Anna Lanzoni, Renata Leuschner, Jochem Louisse, Iris Mangas, Andrea Mioč, Stefanie Nave, Martina Panzarea, Juan Manuel Parra Morte, Hermine Reich, Simone Rizzuto, Silvia Ruocco, Alessia Pia Scarlato, Andrea Simonati, Marta Szot, Andrea Terron, Anne Theobald, Manuela Tiramani, Alessia Verani, Elena Zioga   +35 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Other title: Connecticut substance abuse prevention and treatment block grant

, 2022
Biennial; At head of title: Connecticut.; "Substance Abuse and Mental Health Services Administration, Center for Substance Abuse Treatment, Center for Substance Abuse Prevention.
Connecticut. Department of Mental Health and Addiction Services.
core   +1 more source

Setting of import tolerances for dimethomorph in grapes

EFSA Journal
In accordance with Article 6 of Regulation (EC) No 396/2005, the applicant BASF Agro B.V. Arnhem (NL) Freienbach Branch submitted a request to the competent national authority in the Netherlands to set an import tolerance for the active substance ...
EFSA (European Food Safety Authority), Giulia Bellisai, Giovanni Bernasconi, Luis Carrasco Cabrera, Irene Castellan, Monica delAguila, Lucien Ferreira, Luna Greco, Renata Leuschner, Andrea Mioč, Stefanie Nave, Hermine Reich, Silvia Ruocco, Alessia Pia Scarlato, Marta Szot, Anne Theobald, Manuela Tiramani, Alessia Verani, Elena Zioga   +18 more
doaj   +1 more source

Recent and active problematic substance use among primary care patients: Results from the alcohol, smoking, and substance involvement screening test in a multisite study

, 2021
Background: Primary care settings provide salient opportunities for identifying patients with problematic substance use and addressing unmet treatment need.
Li-Tzy Wu, Greenblatt, Lawrence H, Wu, Li-Tzy, Lawrence H. Greenblatt, John, William S, William S. John, Zhu, He, He Zhu   +7 more
core   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Oxidative stress and DNA damage in drug-naive first-episode psychosis in adolescents

Psychiatry and Clinical Psychopharmacology, 2021
INTRODUCTION: Oxidative stress has been implicated in the psychopathology of schizophrenia, with abnormal activity of antioxidant enzymes, decreased antioxidant levels and increased lipid peroxidation all being demonstrated in patients with ...
Seref Simsek, Salih Gencoglan, Tugba Yuksel, Ibrahim Kaplan, Rumeysa Alaca, Huseyin Aktas   +5 more
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