Results 61 to 70 of about 1,078,147 (263)

Genetic variant of miR-4293 rs12220909 is associated with susceptibility to non-small cell lung cancer in a Chinese Han population. [PDF]

PLoS ONE, 2017
Non-small cell lung cancer is one of the most common cancers and the leading cause of cancer death worldwide. Genetic variants in regulatory regions of some miRNAs might be involved in non-small cell lung cancer susceptibility and survival. rs12220909 (G/
Lixia Fan, Linqi Chen, Xiaoling Ni, Shicheng Guo, Yinghui Zhou, Chenji Wang, Yabiao Zheng, Fangyuan Shen, Vijay Kumar Kolluri, Merlin Muktiali, Zhenhong Zhao, Junjie Wu, Dunmei Zhao, Zhenglei He, Xulong Feng, Ziyu Yuan, Juan Zhang, Li Jin, Jiucun Wang, Minghua Wang   +19 more
doaj   +1 more source

ANN for Predicting DNA Lung Cancer [PDF]

, 2017
: Lung cancer is the top reason of cancer-associated deaths globally. Surgery is the typical treatment for early-stage non-small cell lung cancer (NSCLC).
Bashhar, Bastami, El-Rabi, Emal, Kashf, Wajeeh Abu, Okasha, Nedal, Sahyoun, Ashraf   +4 more
core  

Exploring a structural protein-drug interactome for new therapeutics in lung cancer [PDF]

, 2014
The pharmacology of drugs is often defined by more than one protein target. This property can be exploited to use approved drugs to uncover new targets and signaling pathways in cancer.
Bum-Erdene, Khuchtumur, Jalal, Shadia I., Li, Lang, Li, Liwei, Meroueh, Samy, Peng, Xiaodong, Pollok, Karen, Sandusky, George, Sinn, Tony, Turchi, John, Wang, Bo, Wang, Fang, Xu, David   +12 more
core   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Significance of KRAS/PAK1/Crk pathway in non-small cell lung cancer oncogenesis. [PDF]

, 2015
BackgroundKey effector(s) of mutated KRAS in lung cancer progression and metastasis are unknown. Here we investigated the role of PAK1/Crk axis in transduction of the oncogenic KRAS signal in non-small cell lung cancer (NSCLC).MethodsWe used NSCLC ...
Aljilani, Amir, Lewis, Michael, Lu, Jie, Mortazavi, Fariborz, Pezeshkpour, Gholamhossein, Phan, Ryan, Tamanoi, Fuyuhiko, Trinidad, Kenny   +7 more
core   +2 more sources

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

Usability and Feasibility of Chest Perfusion Computed Tomography in Differentiating Small Cell Lung Cancer and Non-Small Cell Lung Cancer

Archives of Basic and Clinical Research
Objective: We aimed to investigate to usability and feasibility of perfusion computerized tomography (PCT) in differentiating small cell lung cancer (SCLC) from non-small cell lung cancer (NSCLC).
Ömer Özyiğit, Suat Eren
doaj   +1 more source

Chemotherapy for advanced non-small-cell lung cancer: Role of paclitaxel and gemcitabine [PDF]

, 1999
Objective. To review the role of chemotherapy in advanced non-small-cell lung cancer, focusing on cisplatin-based regimens and two new drugs: paclitaxel and gemcitabine. Data sources. Medline search of the relevant English literature.
Ip, MSM, Lam, WK, Tsang, KWT
core  

Trends in incidence and prognosis of the histological subtypes of lung cancer in North America, Australia, New Zealand and Europe [PDF]

, 2001
Background: Since the incidence of the histological subtypes of lung cancer in industrialised countries has changed dramatically over the last two decades, we reviewed trends in the incidence and prognosis in North America, Australia, New Zealand and ...
Coebergh, J.W.W. (Jan Willem), Janssen-Heijnen, M.L.G. (Maryska)   +1 more
core   +3 more sources

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source