Results 231 to 240 of about 1,404,058 (313)

A Vascular Microphysiological Model of Lung Fibrosis Reveals That Myofibroblasts and IPF Patient‐Derived Fibroblasts Impair Angiogenesis and Vasculogenesis

Advanced Functional Materials, EarlyView.
A microphysiological lung fibrosis model recapitulates myofibroblast–vascular interactions. Induced myofibroblasts and patient‐derived IPF fibroblasts impair angiogenesis and increase vascular permeability via TGF‐β1–driven signaling. Pharmacological interventions with SB 431542 and VEGF supplementation restore vascular morphology and barrier function.
Elena Cambria, Adriana Blazeski, Eunkyung Clare Ko, Tran Thai, Shania Dantes, David A. Barbie, Sarah E. Shelton, Roger D. Kamm   +7 more
wiley   +1 more source

Integrated analysis of the oncogenic value of CPNE3 in non-small cell lung cancer. [PDF]

Discov Oncol
Pang P, Tian L, Zhu J, Zeng Y, Xu X, Lin L, Chen S, Huang JA, Du W.   +8 more
europepmc   +1 more source

Tailoring the Properties of Functional Materials With N‐Oxides

Advanced Functional Materials, EarlyView.
The properties of materials bearing N‐oxide groups are often dominated by the polar N+─O− bond. It provides hydrophilicity, selective ion‐binding, electric conductivity, or antifouling properties. Many of the underlying mechanisms have only recently been discovered, and the interest in N‐oxide materials is rapidly growing.
Timo Friedrich, Michelle Kobus, Shirin Mesgarha, Erica Moretto, Laurens Grosche, Wolfgang Maison   +5 more
wiley   +1 more source

Prognostic Implications of SMARCA4, ARID1A, and Other BAF Mutations in Non-Small Cell Lung Cancer. [PDF]

Cancer Med
Khalil A, Collins MP, Quintás-Cardama A.   +2 more
europepmc   +1 more source

AZD9291 in EGFR inhibitor-resistant non-small-cell lung cancer.

New England Journal of Medicine, 2015
P. Jänne, J. Yang, Dong-Wan Kim, D. Planchard, Y. Ohe, S. Ramalingam, M. Ahn, Sang-We Kim, W. Su, L. Horn, D. Haggstrom, E. Felip, Joo‐Hang Kim, P. Frewer, M. Cantarini, K. Brown, P. Dickinson, S. Ghiorghiu, M. Ranson   +18 more
semanticscholar   +1 more source

A Smart Bio‐Battery Facilitates Diabetic Bone Defect Repair Via Inducing Macrophage Reprogramming and Synergistically Modulating Bone Remodeling Coupling

Advanced Functional Materials, EarlyView.
This research presents a novel implantable bio‐battery, GF‐OsG, tailored for diabetic bone repair. GF‐OsG generates microcurrents in high‐glucose conditions to enhance vascularization, shift macrophages to the M2 phenotype, and regulate immune responses.
Nanning Lv, Haifu Sun, Wenxiang Tang, Yonggang Li, Zhonglai Qian, Lihui Hong, Chong Chen, Hongye Li, Jiaxiang Bai, Yusen Qiao, Mingming Liu   +10 more
wiley   +1 more source

Advances on drug therapy for KRAS^G12C-mutant non-small-cell lung cancer. [PDF]

Transl Oncol
Tian T, Li W.
europepmc   +1 more source

Bimetallic Nanoreactor Activates cGAS‐STING Pathway via mtDNA Release for Cancer Metalloimmunotherapy

Advanced Functional Materials, EarlyView.
A bimetallic Mn–Ca nanoreactor (MCC) is developed as a non‐nucleotide STING nanoagonist for cancer metalloimmunotherapy. MCC induces Ca2+ overload and hydroxyl radical generation, resulting in mitochondrial damage and mtDNA release. The released mtDNA cooperates with Mn2+ to robustly activate cGAS–STING signaling.
Xin Wang Mo, Nguyen Thi Nguyen, LiLi Guo, Ngoc Man Phan, Hyunsu Shin, Tae‐il Kim, Yu Seok Youn, Jaeyun Kim   +7 more
wiley   +1 more source

Salvage Surgery Following Systemic Therapy in Initially Unresectable Non-Small Cell Lung Cancer. [PDF]

Thorac Cancer
Seto K, Horio Y, Masago K, Sasaki E, Kuroda H, Matsubayashi Y, Iwashimizu H, Noritake O, Sato K, Matsui T, Suzuki S, Shimizu J, Fujiwara Y, Sakakura N.   +13 more
europepmc   +1 more source