Results 71 to 80 of about 21,276,636 (264)

Infrequent Detection of Microsatellite Alterations in Serum DNA of Non-Small Cell Lung Cancer Patients [PDF]

, 1999
Recent studies indicate that soluble tumor DNA and microsatellite alterations have been identified in the peripheral blood of small cell lung cancer patients.
町田, 恵美, 花岡, 孝臣, 高砂, 敬一郎, 宮澤, 正久, 近藤, 竜一, 矢満田, 健, 藤森, 実, 天野, 純, 羽生田, 正行, 青木, 孝學, 沼波, 宏樹, 金子, 和彦, 牧内, 明子, 福嶋, 義光   +13 more
core  

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Vascular phenotype in angiogenic and non-angiogenic lung non-small cell carcinomas. [PDF]

, 2002
We have previously described a group of non-small cell lung carcinomas without morphological evidence of neo-angiogenesis. In these tumours neoplastic cells fill up the alveoli and the only vessels present appear to belong to the trapped alveolar septa ...
Nicholson, Andrew G., C Ratcliffe, N Singh, P Goldstraw, A G Nicholson, Trivella, M, A Cesario, Granone, Pierluigi, Passalidou, Elisabeth, E Passalidou, Leigh, Irene, Ratcliffe, C, Trivella, Maria-Heleni, Leigh, I, Granone, P, Passalidou, E, Cesario, A, Harris, AL, I Leigh, Nicholson, AG, Pezzella, F, Tetlow, Michelle, Goldstraw, P, Singh, N, J Hu, K C Gatter, Hu, J, Ratcliffe, Cathy, F Pezzella, Goldstraw, Peter, P Granone, A L Harris, Gatter, KC, Singh, Neeta, Gatter, Kevin C., Ferguson, M, Ferguson, Michael, M Trivella, M Ferguson, Tetlow, M, Gatter, Kevin, Pezzella, Francesco, Hu, Jiangting, Harris, Adrian L., M Tetlow, Cesario, Alfredo   +45 more
core   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

HBXIP suppression reduces cell proliferation and migration and its overexpression predicts poor prognosis in non-small-cell lung cancer

Tumor Biology, 2017
Emerging evidence has demonstrated that the high expression of HBXIP has been correlated with many cancers. With evaluation of the functional role of HBXIP in non-small-cell lung cancer, the primary aim of this study is to investigate the correlation ...
Yixuan Wang, Nan Li, Shuanlong Che, Tiefeng Jin, Junjie Piao, Shuangping Liu, Zhenhua Lin   +6 more
doaj   +1 more source

Patient derived cancer-associated fibroblasts from non-small cell lung cancer undergo phenotypic drift in culture

Nanostring nCounter targeted RNA Seq. data of fibroblast cells isolated from human non-cancerous lung tissue and non-small cell lung cancer tumour tissue as well as fibroblasts maintained for three passages in culture from both origins as shown in ...
Koppensteiner, Lilian, Jones, Phoebe, Akram, Ahsan, Dorward, David, Mathieson, Layla, O'Connor, Richard   +5 more
core   +1 more source

Angiogenesis and non-small cell lung cancer

, 2000
Lung cancer is the commonest cause of cancer death in the western world. Recent evidence suggests that angiogenesis is related to poor prognosis in many solid tumours including non-small cell lung cancer.
Walker, R. A., O'Byrne, Kenneth J., Cox, G., Jones, J. L., Steward, W. P.   +4 more
core   +1 more source

Intra-tumour signalling entropy determines clinical outcome in breast and lung cancer. [PDF]

, 2015
The cancer stem cell hypothesis, that a small population of tumour cells are responsible for tumorigenesis and cancer progression, is becoming widely accepted and recent evidence has suggested a prognostic and predictive role for such cells. Intra-tumour
Banerji, CR, Andrew E. Teschendorff (184707), Andrew E Teschendorff, Christopher R S Banerji, Carlos Caldas (1042), Carlos Caldas, Caldas, C, Simone Severini, Teschendorff, AE, Christopher R. S. Banerji (707702), Simone Severini (5662612), Severini, S   +11 more
core   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Immunotherapy in inoperable stage III non-small cell lung cancer: a review

Drugs in Context, 2019
The leading cause of cancer-related deaths in the United States continues to be lung cancer. Approximately 25–30% of patients are diagnosed with locally advanced nonsmall cell lung cancer (NSCLC).
Natasha A Jain, Gregory A Otterson
doaj   +1 more source