Results 101 to 110 of about 36,545 (260)

A Dual‐Bioresponsive and Programmable Microneedle Matrix as a Bioinspired Coupler for Orchestrating Diabetic Bone Regeneration

Advanced Materials, EarlyView.
This project developed a smart bandage‐like patch (a microneedle array) for repairing diabetic bone damage. It intelligently senses signals from infection and inflammation, then releases its medicines in a specific, timed sequence: first an antibacterial agent, then an anti‐inflammatory agent, and finally growth factors.
Yu Wang, Rui Chen, Yu Chen, Haowen Lu, Yuchen Qian, Zhiheng Gao, Zheming Shen, Xiaofei Zheng, Huilin Yang, Jun Zou, Yusen Qiao   +10 more
wiley   +1 more source

Staphylococcus aureus proteins Sbi and Efb recruit human plasmin to degrade complement C3 and C3b

, 2012
Upon host infection, the human pathogenic microbe Staphylococcus aureus (S. aureus) immediately faces innate immune reactions such as the activated complement system. Here, a novel innate immune evasion strategy of S. aureus is described.
Peter F. Zipfel, Christine Skerka, Kraiczy, Peter, Michael Reuter, Reuter, Michael, Skerka, Christine, Barthel, Diana, Diana Barthel, Koch, Tina K., Elsen, Jean van den, Böhm, Sascha, Zipfel, Peter F., Jean van den Elsen, Peter Kraiczy, Tina K Koch, Sascha Böhm, Peter F Zipfel, Tina K. Koch   +17 more
core   +1 more source

BioEISense: A Microfluidic Platform for Real‐Time Monitoring of Staphylococcus aureus Biofilm Formation and the Efficacy of Antibiofilm Agents

Advanced Materials Interfaces, EarlyView.
BioEISense is a microfluidic device with integrated impedance sensors, for real‐time, label‐free monitoring of S. aureus biofilms. In this study, the biofilm culture conditions were optimized to support sensitive and reproducible detection of biofilm formation and eradication under dynamic flow‐through conditions. The system was also validated for both
Jéssica Amorim, Laura Vesalainen, Loïc Dreano, Markus Haapala, Cristina D. Cruz, Päivi Tammela, Tiina M. Sikanen   +6 more
wiley   +1 more source

Antimicrobial resistance among commensal isolates of Escherichia coli and Staphylococcus aureus in the Indonesian population inside and outside hospitals [PDF]

, 2008
The prevalence of antimicrobial resistance among the commensal microflora was examined in the Indonesian population inside and outside hospitals. A total of 3,995 individuals were screened in two major urban centers.
Filius, P. M. G., Verbrugh, H. A., Lestari, ES, Duerink, D. O., Kuntaman, K, Kuntaman , K., Wahjono, H, Severin, Juliette, Severin , J. A, Wahjono, H., Duerink, DO, Hadi, U., Filius, PMG (Margreet), Hadi, U, Lestari , E. S., Verbrugh, Henri   +15 more
core   +1 more source

Dual‐Functional Ingestible Passive Capsules for High‐Throughput Intestinal Sampling with Sealed Containment and Targeted Drug Delivery

Advanced Robotics Research, EarlyView.
To address challenges in high‐throughput intestinal sampling with sealed containment and target drug delivery, we developed a dual‐functional ingestible passive capsule with a dual‐triggered control system based on pH‐response and mechanical actuation.
Libing Huang, Houyu Ling, Xizong Chen, Yufei Duan, Yu Liu, Shuntian Cai, Yandan Ren, Wenlong Li, Lei Ren, Miao Wang   +9 more
wiley   +1 more source

High Humidity Exacerbates Psoriasiform Skin Disease Relapse by Increasing Tissue‐Resident Memory T Cells via Altering Skin Microbiota

Advanced Science, EarlyView.
We demonstrated that high humidity worsened psoriasis relapse in murine psoriasiform skin inflammation by increasing skin‐resident memory CD8+ cells via upregulating IL‐15Rα on keratinocytes. The increases in IL‐15Rα and memory CD8+ cells were attributed to S. nepalensis and its metabolite ADMA in skin exposed to high humidity.
Chun‐Ling Liang, Yuchao Chen, Chuanjian Lu, Huazhen Liu, Fenglian Qin, Sisi Dai, Feifei Qiu, Haiming Chen, Weihui Lu, Jonathan S. Bromberg, Zhenhua Dai   +10 more
wiley   +1 more source

Multi‐Enzyme Mimetic Molybdenum Nitride Nanozymes Reshape Subgingival Microenvironment for Synergistic Periodontitis Therapy via ROS Regulation and Microbiome Remodeling

Advanced Science, EarlyView.
ABSTRACT Periodontitis, a chronic inflammatory disease initiated and sustained by plaque microorganisms and host immune response, remains an intractable oral disease and a leading cause of tooth loss worldwide. Traditional mechanical debridement and adjunctive antibiotic or antiseptic therapy often shows limited efficacy due to the complex anatomical ...
Weiyu Zhang, Zhongwei Yang, Yunfan Zhang, Longwei Wang, Xiaoyu Zhang, Jiahui Mao, Yizhi Dai, Yifan Yuan, Mingge Wang, Xin Yang, Xin Yu, Jing Liu, Chunying Chen   +12 more
wiley   +1 more source

Quantitative Mass Spectrometry‐Based Biodistribution of Monoclonal Antibodies: An Alternative to Radio‐Biodistribution

Advanced Science, EarlyView.
Monoclonal antibodies are powerful anticancer therapeutics targeting tumor‐associated antigens. Mass spectrometry enables precise and accurate quantification of mAbs in tumor plasma and healthy organs. Unlike ligand binding assay and radioactivity, mass spectrometry does not suffer from matrix effects and labelling artefacts while facilitating method ...
Domenico Ravazza, Sheila Dakhel Plaza, Samuele Cazzamalli, Andrea Ciamarone, Andrea Galbiati, Riccardo Stucchi, Frederik Peissert, Emanuele Puca, Dario Neri, Ettore Gilardoni   +9 more
wiley   +1 more source

Macrophage Extracellular Traps in Immunity and Cancer

Advanced Science, EarlyView.
As a macrophage‐mediated innate defense mechanism, the dysregulated release of METs drives chronic inflammation and influences tumor progression. Furthermore, METs exhibit a functional duality within the tumor microenvironment, capable of both promoting and suppressing tumor development.
Junyao Li, Eugenie Nepovimova, Adam Grundel, Lukas Peter, Qinghua Wu, Kamil Kuca   +5 more
wiley   +1 more source

Non-aureus staphylococci and mammaliicocci isolated from dairy cow milk and their relationships with the presence of mastitis: a retrospective investigation

, 2023
Abstract Non-aureus staphylococci and mammaliicocci (NASM) have been associated with bovine mastitis and increased milk somatic cell count (SCC) but their relationships with mammary gland health at the species level are not completely understood. The implementation of MALDI-TOF MS in milk microbiology is generating large and dependable datasets
Maria Filippa Addis, Clara Locatelli, Martina Penati, Sara Fusar Poli, Valentina Monistero, Lucia Zingale, Nicola Rota, Claudia Gusmara, Renata Piccinini, Paolo Moroni, Valerio Bronzo   +10 more
openaire   +1 more source