Results 121 to 130 of about 10,217,790 (260)

Pyrazole‐Derived Antibacterial Compounds Effectively Treat Methicillin‐Resistant Staphylococcus Aureus Infections by Inhibiting Aspartate Transcarbamoylase

Advanced Science, EarlyView.
This study unveils a novel antibacterial mechanism against MRSA, in which the compound Py‐27 selectively targets and inhibits aspartate transcarbamoylase (ATCase), a key enzyme in pyrimidine synthesis. This inhibition disrupts DNA replication, induces oxidative damage, leading to potent bactericidal activity.
Xiaorong Yang, Xinyuan Cao, Lixia Dai, Feng Yang, Jing Wang, Yudong Ma, Tong Bu, Zile Gong, Xueyan Liu, Changcai Bai, Xiaolou Miao, Xiaofei Shang   +11 more
wiley   +1 more source

Antibiotic Resistance Pattern of Isolated Strains of Staphylococcus Aureus from Personnel Nasal Specimens in Meshgin Shahr Valiasr Hospita [PDF]

Background & Objectives: Staphylococcus aureus is known as an important pathogen causing a variety of bacterial infections. Treatment of this bacterium with antibiotics has led to antibiotic-resistancy, especially against methicillin (MRSA) and more ...
کریم وند, نسیم, نيك بخت, مجتبي, حسن نژاد, سيامك, فرجي, فاطمه, رضازاده, بابك, قرباني, فياض, نقی زاده باقی, عباس   +6 more
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The Staphylococcus aureus Response to Unsaturated Long Chain Free Fatty Acids: Survival Mechanisms and Virulence Implications. [PDF]

, 2009
Staphylococcus aureus is an important human commensal and opportunistic pathogen responsible for a wide range of infections. Long chain unsaturated free fatty acids represent a barrier to colonisation and infection by S.
Horsburgh Malcolm J., Ward, D, Rees, HH, Ward Deborah, Elisabet Josefsson, Kenny John G., Lindsay Jodi A., John G Kenny, Tarkowski Andrej, Horsburgh, MJ, Hinds Jason, Jonsson Ing-Marie, Ing-Marie Jonsson, Huw H Rees, Deborah Ward, Josefsson Elisabet, Tarkowski, A, Lindsay, JA, Malcolm J Horsburgh, Josefsson, E, Kenny, JG, Hinds, J, Jodi A Lindsay, Rees Huw H., Jason Hinds, Andrej Tarkowski, Jonsson, IM   +26 more
core   +2 more sources

The IRE1‐XBP1s Axis Drives Inflammatory Osteolysis by Regulating a 5‐HT Dependent Endogenous Anti‐Autophagy Mechanism

Advanced Science, EarlyView.
A previously unrecognized IRE1‐XBP1s‐Slc6a4 signaling axis links endoplasmic reticulum stress to serotonin metabolism, autophagy, and inflammatory osteoclastogenesis. By promoting intracellular serotonin uptake and reducing endogenous 3‐methyladenine accumulation, this pathway accelerates inflammatory bone destruction and provides a promising ...
Pengchao Yang, Binxiang Zhu, Yuzhi He, Yang Tian, Honglei Kang, Shian Hu, Pengju Wang, Yong Xu, Zhuowei Lei, Peijun Qi, Hao Yang, Yang Lin, Yimin Dong, Feng Li, Hanfeng Guan   +14 more
wiley   +1 more source

Deterministic model to evaluate the impact of lactational treatment of subclinical mastitis due to coagulase-negative staphylococci [PDF]

, 2011
Coagulase-negative staphylococci (CNS) are the most frequently isolated bacteria from milk samples in several studies worldwide. Despite their relative frequency, specific measures aiming at their control are not well established. One possible measure to
Ellis, K.A., Ricardo Bexiga, Bexiga, R., Mellor, D.J., Vilela, C.L., Kathryn A Ellis, Dominic J Mellor, Cristina L Vilela   +7 more
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Modulating Calcium Homeostasis via a Biomimetic Scaffold to Rescue Diabetic Ischemic Wounds

Advanced Science, EarlyView.
This strategy addresses impaired microcirculation and loss of extracellular matrix (ECM) guidance in diabetic wound healing. Musc@CP, a nanofibrous dressing combining an ECM‐mimetic chitosan‐pullulan scaffold with muscone, enhances perfusion by attenuating intracellular Ca2+ overload‐associated endothelial dysfunction.
Xiang Zheng, Mingmei Li, Jianjun Jiang, Yongchao Wang, Yaru Jia, Weilun Sun, Yi Yao, Pengli Gao, Linhua Zhang, Qi Guo, Guang Jia, Xing‐Jie Liang, Dunwan Zhu, Jinchao Zhang, Fangzhou Li   +14 more
wiley   +1 more source

Multifunctional Manganese Oxide Nanocomposite Hydrogel With Synergistic Reactive Oxygen Species‐Scavenging, Oxygen‐Generating, Immunomodulatory, and Photothermal Antimicrobial Activities for Enhanced Diabetic Wound Healing

Advanced Science, EarlyView.
CFP/PC@MnO2 hydrogel integrates ROS scavenging, oxygen delivery, oxidative stress reduction, immunomodulation, and photothermal antibacterial properties. The incorporation of PC@MnO2 NPs endows the hydrogel with multiple functional advantages tailored to the pathological microenvironment of diabetic wounds, including efficient ROS clearance, mitigation
Zhi Xu, Xiaodong Luo, Jingxian Wu, Chaoyang Huang, Zhuoying Yang, Yixiang HePeng, Bosong Zhou, Xiang Li, Ruiyuan Liu, Xu Wu   +9 more
wiley   +1 more source

High prevalence of nasal MRSA carriage in slaughterhouse workers in contact with live pigs in The Netherlands. [PDF]

, 2010
Item does not contain fulltextLivestock-associated MRSA has been found in various animals, livestock farmers and retail meat. This study aimed to determine the prevalence and determinants of nasal MRSA carriage in pig slaughterhouse workers.
Kluytmans, J.A., Voss, A., Cleef, B.A.G.L., van, Mulders, M.N., Broens, E.M., Kluijtmans, J.A.J.W., Cleef, B.A. van, van Benthem, B.H.B., van Cleef, B.A.G.L., Benthem, B.H. van, Giessen, A.W., van de, Huijsdens, X.W., Giessen, A.W. Van De, van de Giessen, A.W., Zuchner, L., Kluytmans, J.A.J.W., Benthem, B.H.B., van, Voss, A   +17 more
core   +1 more source

Metal‐Half‐Salen Chemistry for One‐Pot Mineralization on Hydrophobic Polymer Membranes

Advanced Science, EarlyView.
Here we report a versatile one‐pot synthetic strategy for organic–inorganic composite membranes, which leverages a metal half‐Salen system to precisely govern the competing kinetics of coordination and hydrolysis. In contrast to conventional two‐step metal‐phenol chemistries, our integrated approach substantially simplifies the fabrication process ...
Rou‐Ming Wen, Hao Ye, Ming‐Bang Wu, Lu‐Lin Ma, Qi‐Hui Ye, Zi‐Hao Yuan, Yi Xie, Juming Yao, Hao‐Cheng Yang   +8 more
wiley   +1 more source

Green synthesis of silver nanoparticles and their inhibitory effects on resistant udder pathogens

Journal of Applied Animal Research
The study covers a new process for synthesizing silver nanoparticles using dry lavender leaves (Lav-AgNPs) as a reducing and stabilizing agent, and evaluation of their inhibitory effect on the resistant udder pathogens. Of all 480 investigated dairy cows,
Silvia Ondrašovičová, František Zigo, Zuzana Farkašová, Zuzana Lacková, Oksana Velgosova, Lívia Mačák, Jana Záhumenská, Ewa Pecka-Kiełb, Mária Vargová, Jana Ondrašovičová, Ibrahim F. Rehan   +10 more
doaj   +1 more source