Results 121 to 130 of about 24,186,788 (290)

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

A Multimodal Deep Learning Model for the Classification of Breast Cancer Subtypes

Diagnostics
Background: Breast cancer is a heterogeneous disease with distinct molecular subtypes, each requiring tailored therapeutic strategies. Accurate classification of these subtypes is crucial for optimizing treatment and improving patient outcomes.
Chaima Ben Rabah, Aamenah Sattar, Ahmed Ibrahim, Ahmed Serag   +3 more
doaj   +1 more source

Demographic characteristics and subtypes of study subjects.

, 2013
aNon parametric Kruskal Wallis test was applied.bCompared the constitutions of subtypes between heterosexual contact and intravenous drug injection.
Yanling Ma (169386), Chaojun Yang (394771), Yuhua Shi (379491), Wenyun Yan (379492), Manhong Jia (379490), Ling Chen (25698), Min Chen (147733), Li Yang (6520), Huichao Chen (394773), Lin Lu (5759), Yingzhen Su (394770), Hongbing Luo (394772)   +11 more
core   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Identification and characterisation of calcitonin receptor isoforms expressed in glioblastoma derived glioma stem and U‐87 MG cells

FEBS Open Bio, EarlyView.
Glioblastoma cells express calcitonin receptor variants (CT receptor isoforms) that may help them survive stress. Using qPCR, transcript‐specific long‐read nanopore sequencing, immunofluorescence co‐localisation and comparative sequence analysis, this study identifies a novel alternatively spliced CALCR transcript that encodes the CTb receptor isoform ...
Pragya Gupta, Sebastian GB Furness, Tahereh Gharbi, Ric De Paoli‐Iseppi, Shweta S. Joshi, Michael Clark, David L. Hare, Peter Wookey   +7 more
wiley   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Hematopoietic stem cell heterogeneity in non-human primates revealed by five-lineage output bias analysis

Blood Science
Understanding hematopoietic stem cell (HSC) heterogeneity is crucial for treating malignant blood disorders. Compared with mice, we have limited knowledge of the heterogeneity of human HSCs.
Man Zhang, Di Liu, Yu Lan, Bing Liu, Zongcheng Li, Yanli Ni   +5 more
doaj   +1 more source

HIV subtypes in Scotland, 2000-2006

, 2008
The purpose of this study was to document the dynamics of HIV-1 subtypes in Scotland over a 6-year period. Viral RNA from all-new diagnoses was amplified by nested PCR and sequenced in the gag and/or env regions.
Shaw, L., Cameron, S. O., Goldberg, D., Campbell, E., Burns, S. M., Yirrell, D. L.   +5 more
core   +1 more source

Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells

FEBS Open Bio, EarlyView.
Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla, Martín M. Ledesma, Santiago A. Behr, Matías A. Pibuel, María L. Palanek, Daniel H. Grasso, Maria N. Garcia, Juan Garona, Silvina L. Lompardía, Elida Álvarez, Daniela L. Papademetrio   +10 more
wiley   +1 more source

Laboratory analysis of 182 cases of B-cell lymphoproliferative disorders other than typical chronic lymphocytic leukemia: Single-center study

Iraqi Journal of Hematology
BACKGROUND: Chronic mature B-cell lymphoproliferative disorders (B-LPDs) are characterized by the clonal proliferation of mature B-lymphocytes in the peripheral blood (PB), bone marrow, and lymphoid tissues.
Shams Salah Mahdi, Nuha Abd Ali Al-Sarai
doaj   +1 more source