Results 141 to 150 of about 24,186,788 (290)

Subtype-specific atypical B cell profiles in myasthenia gravis reveal distinct immunopathological pathways

Frontiers in Immunology
IntroductionAtypical B cell (atBC) subsets display significant heterogeneity across autoimmune diseases, complicating efforts to define their role and therapeutic potential.
Patricia M. Sikorski, Henry J. Kaminski, Angela Vincent, Taylor Bauman, Leslie Jacobson, Linda L. Kusner   +5 more
doaj   +1 more source

Comparative Effectiveness and Safety of Inebilizumab Versus Rituximab in AQP4‐IgG‐Positive NMOSD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rituximab (anti‐CD20, RTX) and inebilizumab (anti‐CD19, INE) represent B‐cell‐depleting therapies used for aquaporin‐4 antibody‐positive (AQP4‐IgG+) neuromyelitis optica spectrum disorder (NMOSD); however, direct comparative evidence remains limited.
Jie Lin, Binbin Xue, Dewei Xie, Jia Li, Juyuan Pan, Lanbing Zhu, Qiaowen Tong, Jing Lin, Ruofan Zhu, Xu Zhang, Junhui Xia, Xiang Li   +11 more
wiley   +1 more source

Differences in the frequency of minor substitutions between HIV-1 subtypes and their potential impact on the genetic barrier for resistance to protease inhibitors

, 2005
BACKGROUND: The number of minor protease substitutions in wild-type virus at positions targeted during antiretroviral drug treatment, varies considerably between HIV-1 subtypes.
I. M. Hoepelman, G. Angarano, C. de Mendoza, K. Van Laethem, E. MacRae, A. M. Wensing, G. Stanczak, K. Wilbe, E. Puchhammer Stockl, L. Meyer, L. Ruiz, M. L. Chaix, Z. Grossman, D. Costagliola, C. Kucherer, M. Violin, C. Balotta, A. Hatzakis, O. Hamouda, V. Soriano, F. Schneider, K. Korn, J. C. C. Schmit, E. L. de Coul, R. Hemmer, V. Ormaasen, T. Leitner, D. Paraskevis, C. Loveday, L. Perrin, A. M. Vandamme, I. Maljkovic, D. V. de Vijver, A. de Luca, I. Derdelinckx, M. Zazzi, B. Asjo, E. Boeri, R. Camacho, M. Salminen, M. Stanojevic, C. Nielsen, R. Schuurman, A. Horban, C. A. B. Boucher, S. Yerly   +45 more
core   +2 more sources

Preoperative Adult-Type Diffuse Glioma Subtype Prediction with Dynamic Contrast-Enhanced MR Imaging and Diffusion Weighted Imaging in Tumor Cores and Peritumoral Tissue—A Standardized Multicenter Study

Diagnostics
Background/Objectives: The non-invasive identification of glioma subtypes is useful for initial diagnosis, treatment planning, and follow-up. The aim of this study was to evaluate the performance of diffusion kurtosis imaging (DKI) and dynamic contrast ...
Leonie Zerweck, Uwe Klose, Urs Würtemberger, Vivien Richter, Thomas Nägele, Georg Gohla, Kathrin Grundmann-Hauser, Arne Estler, Christer Ruff, Gunter Erb, Ulrike Ernemann, Till-Karsten Hauser   +11 more
doaj   +1 more source

Spatial and Volumetric Characteristics of Glioblastoma: Associations With Clinical Presentation and Survival

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective We aim to comprehensively analyze how regional tumor and edema characteristics are associated with clinical presentations and survival outcomes in a large cohort of glioblastoma patients. Methods Patients with IDH‐wildtype glioblastoma who received brain MRI from 2010 to 2023 were included.
Daniel J. Zhou, Marc Jaskir, Julian Gal, Yombe Fonkeu, Christos Davatzikos, MacLean P. Nasrallah, Jose Garcia, Rubo Xing, Stephen J. Bagley, Arati Desai, Richard E. Phillips, Steven Tobochnik, Colin A. Ellis, James J. Gugger, Nishant Sinha, Joel M. Stein, Kathryn A. Davis   +16 more
wiley   +1 more source

HIV-1 subtypes and circulating recombinant forms (CRFs) from HIV-infected patients residing in two regions of central and southern Italy

, 2005
A total of 347 pol gene sequences from88 Tuscan and 259 Apulian subjects (including 52 non- Italians and 9 children) were analyzed phylogenetically. Forty-four (12.6%) non-B subtypes were found, including 3.4% C, 1.4% F1, 0.8% G, and 0.3% each for J
BALOTTA C, SARACINO, ANNALISA, ANGARANO, Gioacchino, MAZZOTTA F, PUNZI G, PIEROTTI P, MONNO, Laura, DI BARI C, BRINDICCI G, LAGIOIA A, LO CAPUTO S, SCARABAGGIO T, RIVA C, G. Angarano, A. Lagioia, S. Lo Caputo, T. Scarabaggio, C. Balotta, G. Brindicci, C. Riva, F. Mazzotta, A. Saracino, L. Monno, G. Punzi, P. Pierotti, C. Di Bari   +25 more
core   +1 more source

Comprehensive Characterization of 98 Chinese Cases of Genetic Creutzfeldt‐Jakob Disease With T188K Mutation

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterize the demographic, clinical, and laboratory features of the Chinese patients of genetic Creutzfeldt‐Jakob disease with T188K variant (T188K‐gCJD), the most common subtype of genetic prion diseases (gPrDs) in China. Methods In this nationwide retrospective study, data from 98 genetically confirmed T188K‐gCJD patients ...
Chun‐Jie Li, Dong‐Lin Liang, Li‐Ping Gao, Wei‐Wei Zhang, Wei Zhou, A. Ruhan, Bing Xu, Run‐Dong Cao, Kang Xiao, Cao Chen, Qi Shi, Xiao‐Ping Dong   +11 more
wiley   +1 more source

Sex‐Stratified Association of Regional Dopamine Transporter Binding With Disease Progression in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To clarify the clinical relevance of dopamine transporter single‐photon emission computed tomography (DAT‐SPECT) abnormalities in amyotrophic lateral sclerosis (ALS), with a prespecified focus on sex‐stratified associations with disease progression and short‐term prognosis.
Tomoya Kawazoe, Keizo Sugaya, Kentaro Hayashi, Keiko Hino, Yasuhiro Nakata, Kota Bokuda, Toshio Shimizu, Kazushi Takahashi   +7 more
wiley   +1 more source

First-line HIV treatment failures in non-B subtypes and recombinants: a cross-sectional analysis of multiple populations in Uganda. [PDF]

AIDS Res Ther, 2019
Poon AFY, Ndashimye E, Avino M, Gibson R, Kityo C, Kyeyune F, Nankya I, Quiñones-Mateu ME, Arts EJ, The Ugandan Drug Resistance Study Team.   +9 more
europepmc   +1 more source

Plasma EV Proteomics Identifies ECM Remodeling and Inflammatory Proteins LUM and C7 as Candidate Biomarkers in FSHD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit, Chiranth K. Nagaraj, Jackson S. Newell, Kim Truc Nguyen, Xilal Y. Rima, Jacob Doon‐Ralls, Eduardo Reátegui, Jeffrey M. Statland, Rabi Tawil, Kevin M. Flanigan, Scott Q. Harper, Nizar Y. Saad   +11 more
wiley   +1 more source