Results 121 to 130 of about 12,851,211 (266)

Recent insights into the molecular mechanism of ubiquinol oxidation by cytochrome bc1

FEBS Open Bio, EarlyView.
The review reflects on the mechanism of the catalytic reaction in cytochrome bc1: the electron bifurcation that involves the separation of two electrons derived from the quinol oxidation to opposite sides of the enzyme across the membrane. This review summarizes the long‐standing effort to understand the mechanism of quinol oxidation catalyzed by ...
Anna Wójcik‐Augustyn, Artur Osyczka, Marcin Sarewicz   +2 more
wiley   +1 more source

Affinity-based recovery of metabolically active microbial cells using BioOrthogonal Non-Canonical amino acid tagging

Current Research in Biotechnology
Selective identification of translationally active cells remains a key challenge in linking microbial function to population dynamics. Bioorthogonal non-canonical amino acid tagging (BONCAT) enables pulse-labelling of newly synthesized proteins in live ...
Yumechris Amekan, Sarah Forrester, Annabel Cansdale, Marjan W. van der Woude, Kelly R. Redeker, James P.J. Chong   +5 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Considerations for the genotoxicity assessment of middle size peptide drugs containing non-canonical amino acid residues. [PDF]

Genes Environ, 2023
Mishima M, Sugiyama KI.
europepmc   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

Sequence and structural insights of monoleucine-based sorting motifs contained within the cytoplasmic domains of basolateral proteins

Frontiers in Cell and Developmental Biology
Delivery to the correct membrane domain in polarized epithelial cells is a critical regulatory mechanism for transmembrane proteins. The trafficking of these proteins is directed by short amino acid sequences known as sorting motifs. In six basolaterally-
Sarah J. Harmych, Sarah J. Harmych, Claiborne W. Tydings, Jens Meiler, Jens Meiler, Bhuminder Singh, Bhuminder Singh   +6 more
doaj   +1 more source

Early Clinical, Imaging, and Pathological Characteristics of SRPK3/TTN‐Digenic Myopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SRPK3/TTN‐digenic myopathy was recently established as a skeletal muscle myopathy caused by digenic inheritance. This study characterizes the early clinical presentation of SRPK3/TTN‐digenic myopathy in one previously reported and seven newly identified pediatric patients.
Rotem Orbach, Sandra Donkervoort, Carola Hedberg‐Oldfors, Giovanni Baranello, Dimah Saade, Precilla D'Souza, Ruchee Patel, Eva Michael, A. Reghan Foley, Diana Bharucha‐Goebel, S. Jin Haugland, Meghan McAnally, Omer Abdul Hamid, Katherine Chao, Ellen F. Macnamara, Alan H. Beggs, Anna Sarkozy, Juliane Mueller, Steven A. Moore, Richard S. Finkel, Cynthia J. Tifft, Francesco Muntoni, Anders Oldfors, Carsten G. Bönnemann   +23 more
wiley   +1 more source

Evidence for two pharmacologically distinct populations of glutamate-activated first order interneurons in a vertebrate spinal cord.

, 1987
p. 357-360.The Atlantic stingray, Dasyatis sabina, is being employed as a simple vertebrate model for studying spinal cord circuitry. Current investigations are aimed at determining the role of excitatory amino acids in the production of spinal reflexes.
Leonard, R.B., Gannon, R.L.
core   +1 more source

Dual-BONCAT reveals distinct subpopulations of anabolically active cells

Applied and Environmental Microbiology
Bio-orthogonal non-canonical amino acid tagging (BONCAT) has emerged as a prominent molecular technique that enables microbial ecologists to visualize and identify metabolically active cells in cultures and complex microbial communities.
Dylan Mankel, Yasheng Maierhaba, Claire Momjian, Federica Calabrese, Solange Duhamel, Jeffrey Marlow   +5 more
doaj   +1 more source

Co-translational Installation of Posttranslational Modifications by Non-canonical Amino Acid Mutagenesis. [PDF]

Chembiochem, 2023
Niu W, Guo J.
europepmc   +1 more source