Results 61 to 70 of about 262,938 (280)

Extending enzyme molecular recognition with an expanded amino acid alphabet

, 2017
Natural enzymes are constructed from the twenty proteogenic amino acids, which may then require post-translational modification or the recruitment of coenzymes or metal ions to achieve catalytic function.
Adam Nelson, Alan Berry, Arwen R. Pearson, Baker, Chalker, Chi H. Trinh, Claire L. Windle, Daniels, Dondoni, Drienovska, Dumas, Díaz-Rodríguez, Hekking, Howard, Huang, James R. Ault, Katie J. Simmons, Montclare, Pradhan, Royer, Timms, Ugwumba, Warren, Williams, Windle, Yukl, Zhang   +26 more
core   +1 more source

BCKDH: the missing link in apicomplexan mitochondrial metabolism is required for full virulence of Toxoplasma gondii and Plasmodium berghei [PDF]

, 2014
While the apicomplexan parasites Plasmodium falciparum and Toxoplasma gondii are thought to primarily depend on glycolysis for ATP synthesis, recent studies have shown that they can fully catabolize glucose in a canonical TCA cycle.
Barrett, Michael P., Billker, Oliver, Creek, Darren J., Limenitakis, Julien, Macrae, James I., McConville, Malcolm J., Modrzynska, Katarzyna K., Oppenheim, Rebecca D., Pino, Paco, Polonais, Valerie, Seeber, Frank, Soldati-Favre, Dominique   +11 more
core   +1 more source

Ribosome-mediated polymerization of long chain carbon and cyclic amino acids into peptides in vitro

Nature Communications, 2020
Backbone extended monomers are poorly compatible with the natural ribosomes, impeding their polymerization into polypeptides. Here the authors design non-canonical amino acid analogs with cyclic structures or extended carbon chains and used an engineered
Joongoo Lee, Kevin J. Schwarz, Do Soon Kim, Jeffrey S. Moore, Michael C. Jewett   +4 more
doaj   +1 more source

WNT5B in Physiology and Disease

Frontiers in Cell and Developmental Biology, 2021
WNT5B, a member of the WNT family of proteins that is closely related to WNT5A, is required for cell migration, cell proliferation, or cell differentiation in many cell types.
Sarocha Suthon, Rachel S. Perkins, Vitezslav Bryja, Vitezslav Bryja, Gustavo A. Miranda-Carboni, Gustavo A. Miranda-Carboni, Susan A. Krum, Susan A. Krum   +7 more
doaj   +1 more source

Small and large intestine express a truncated Dab1 isoform that assembles in cell-cell junctions and co-localizes with proteins involved in endocytosis [PDF]

, 2018
Disabled-1 (Dab1) is an essential intracellular adaptor protein in the reelin pathway. Our previous studies in mice intestine showed that Dab1 transmits the reelin signal to cytosolic signalling pathways.
Balda, María S., García Miranda, Pablo, Ilundáin Larrañeta, María Anunciación Ana, Matter, Karl, Peral Rubio, María José, Vázquez Carretero, María Dolores   +5 more
core   +1 more source

Engineering double-stranded RNA binding activity into the Drosha double-stranded RNA binding domain results in a loss of microRNA processing function.

PLoS ONE, 2017
Canonical processing of miRNA begins in the nucleus with the Microprocessor complex, which is minimally composed of the RNase III enzyme Drosha and two copies of its cofactor protein DGCR8.
Joshua C Kranick, Durga M Chadalavada, Debashish Sahu, Scott A Showalter   +3 more
doaj   +1 more source

Teaching old NCATs new tricks: using non-canonical amino acid tagging to study neuronal plasticity [PDF]

, 2013
The non-canonical amino acid labeling techniques BONCAT (bioorthogonal non-canonical amino acid tagging) and FUNCAT (fluorescent non-canonical amino acid tagging) enable the specific identification and visualization of newly synthesized proteins ...
Dieterich, D .C., Hinz, F. I., Schuman, E. M.   +2 more
core  

Antimicrobial Peptides Produced by Selective Pressure Incorporation of Non-canonical Amino Acids [PDF]

, 2018
Nature has a variety of possibilities to create new protein functions by modifying the sequence of the individual amino acid building blocks. However, all variations are based on the 20 canonical amino acids (cAAs).
Bartholomae, Maike, Baumann, Tobias, Budisa, Nediljko, Friedrich, Thomas, Kuipers, Oscar P, Nickling, Jessica H, Schmitt, Franz-Josef   +6 more
core   +2 more sources

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Rosetta FlexPepDock to predict peptide-MHC binding: An approach for non-canonical amino acids.

PLoS ONE, 2022
Computation methods that predict the binding of peptides to MHC-I are important tools for screening and identifying immunogenic antigens and have the potential to accelerate vaccine and drug development.
Nathaniel Bloodworth, Natália Ruggeri Barbaro, Rocco Moretti, David G Harrison, Jens Meiler   +4 more
doaj   +3 more sources