Results 111 to 120 of about 46,555 (278)

Intracellular Aβ42 Sequestration by a Serine Protease Mitigates Neurotoxicity in a Drosophila Alzheimer's Disease Model

Advanced Science, EarlyView.
Emerging evidence suggests that intraneuronal Aβ accumulation represents an early pathogenic event in Alzheimer's disease (AD). Using Drosophila AD model, this study shows that a nonsecreted serine protease Yip7 physically interacts with Aβ. This causes intraneuronal Aβ accumulation but surprisingly reduces the associated neurotoxicity, arguing that ...
Jingyun Su, Meng Yang, Xinfeng Wang, Pa Wu, Zongzhao Zhai   +4 more
wiley   +1 more source

Advances in genetic tools for metabolic engineering of non-conventional yeasts

Frontiers in Synthetic Biology
Non-conventional yeasts are emerging as powerful alternatives to Saccharomyces cerevisiae for metabolic engineering, owing to their innate stress tolerance, broad substrate utilization, and distinctive metabolic capabilities.
Thasneem Banu Frousnoon, Thasneem Banu Frousnoon, Stephen Mondo, Yasuo Yoshikuni, Yasuo Yoshikuni, Yasuo Yoshikuni, Yasuo Yoshikuni, Yasuo Yoshikuni, Yasuo Yoshikuni   +8 more
doaj   +1 more source

Autophagic flux is required for the synthesis of triacylglycerols and ribosomal protein turnover in Chlamydomonas [PDF]

, 2018
Autophagy is an intracellular catabolic process that allows cells to recycle unneeded or damaged material to maintain cellular homeostasis. This highly dynamic process is characterized by the formation of double-membrane vesicles called autophagosomes ...
Couso Liáñez, Inmaculada Concepción, Crespo González, José Luis, Kim, Hee-Sik, Martínez Force, Enrique, Pérez Pérez, María Esther   +4 more
core   +1 more source

Diversity of Pharmaceuticals Enhances Antibiotic Resistance in the Invertebrate Gut via Biofilm‐Mediated Mechanisms

Advanced Science, EarlyView.
Pharmaceutical diversity acts as an independent driver of antibiotic resistance in soil invertebrates. While bulk soil remains unaffected, the collembolan gut microbiome exhibits significant resistance gene enrichment under complex chemical exposure and diurnal warming.
Yi‐Fei Wang, Ya‐Ning Wang, Da Lin, Jia‐Yang Xu, Feng‐Yuan Qi, Hui‐Ling Cui, Hui‐Jie Lu, Min Qiao, Edward Topp, Dong Zhu, Matthias C. Rillig, Yong‐Guan Zhu   +11 more
wiley   +1 more source

Preliminary Screening of Non-Conventional Yeasts for Olive Mill Wastewater Valorization

Fermentation
Olive mill wastewater (OMWW) is a highly polluting agro-industrial effluent characterized by elevated organic load, low pH, and high concentrations of phenolic compounds responsible for its phytotoxicity and dark coloration.
Gabriella Siesto, Rocchina Pietrafesa, Antonio Caporusso, Giorgia La Rocca, Grazia Alberico, Vito Valerio, Angela Capece   +6 more
doaj   +1 more source

Microbiological quality of Moroccan labeled Euphorbia resinifera honey [PDF]

, 2017
In the present work, microbiological profile of thirty-seven samples of labeled honey were collected in a Protected Geographical Indication “PGI” area of Tadla-Azilal region, which is an endemic zone of Euphorbia resinifera plant.
Benbachir, Maryam, Eddoha, Rabiaa, Moujanni, Abdelkarim, Nasser, Boubker, Terrab Benjelloun, Anass   +4 more
core  

DNA Replication Errors Drive Genome‐Wide Small Inverted Triplication Dynamics

Advanced Science, EarlyView.
This study provides insight into the dynamic equilibrium mechanism of a novel structural variant, small inverted triplication (SIT), which is generated by misalignment of the 3’ flap generated under DNA replication stress with palindromic sequence. Alternatively, the end sequence may fold back on itself to form an inverted fragment.
Yi Lei, Yu Zhou, Haitao Sun, Hang Yuan, Xinyu Pei, Jessica D. Hess, Yao Yan, Zunsong Hu, Mian Zhou, Zhaohui Gu, Li Zheng, Xiwei Wu, Binghui Shen   +12 more
wiley   +1 more source

CR3 and Dectin-1 Collaborate in Macrophage Cytokine Response through Association on Lipid Rafts and Activation of Syk-JNK-AP-1 Pathway [PDF]

, 2015
Copyright: © 2015 Huang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source ...
Brown, Gordon D, Chen, Wen-Yu, Chu, Ching-Liang, Chuu, Chih-Pin, Huang, Juin-Hua, Lin, Ching-Yu, Wu, Sheng-Yang, Wu-Hsieh, Betty A   +7 more
core   +4 more sources

Epithelial TRIM27 Inhibits Intestinal Inflammation in Ulcerative Colitis by the USP7/TRIM27‐IKK Double Negative‐Feedback

Advanced Science, EarlyView.
ABSTRACT The E3 ubiquitin ligase tripartite motif 27 (TRIM27) is a negative regulator of NF‐κB activation and the innate immune response, and TRIM27 deficiency significantly impairs dextran sulfate sodium (DSS)‐induced colitis. The function of TRIM27 in intestinal epithelial cells (IECs), the mechanism by which TRIM27 inhibits the NF‐κB pathway and its
Weimin Xu, Zhebin Hua, Zhujiang Dai, Shasha Zhang, Yihan Jiang, Wensong Ge, YingWei Chen, Zhongchuan Wang, Bing Zhang, Chen‐Ying Liu, Peng Du   +10 more
wiley   +1 more source

Technologies for restricting mould growth on baled silage [PDF]

, 2007
End of project reportSilage is made on approximately 86% of Irish farms, and 85% of these make some baled silage. Baled silage is particularly important as the primary silage making, storage and feeding system on many beef and smaller sized farms, but is
Clipson, Nicholas J.W., Doohan, Fiona, Doyle, Evelyn M., Egan, Damian, Forristal, Dermot, Frisvad, Jens C., Fuller, Hubert T., Laffin, Christopher, McEniry, Joseph, McNally, Gerard M., Nielsen, Kristian F., O'Brien, Martin, O'Kiely, Padraig, Small, Christopher M.   +13 more
core