Results 51 to 60 of about 351,052 (293)

Selective glucocorticoid receptor properties of GSK866 analogs with cysteine reactive warheads [PDF]

, 2017
Synthetic glucocorticoids (GC) are the mainstay therapy for treatment of acute and chronic inflammatory disorders. Due to the high adverse effects associated with long-term use, GC pharmacology has focused since the nineties on more selective GC ligand ...
Atucha, Avenant, Baiula, Barnes, Bauer, Baumer, Beck, Berk, Biggadike, Bledsoe, Bonvini, Carson, Cheatham, Chen, Corne, De Bosscher, De Bosscher, De Bosscher, De Vos, Desmet, Desmet, Engel, Garuti, Helsens, Lieber, Liu, Madauss, Mcmaster, Meijsing, Newton, Newton, Perkins, Proksch, Ratman, Rehman, Reichardt, Rhen, Roskoski, Ryabtsova, Schacke, Schacke, Schacke, Schacke, Schindelin, Schuttelkopf, Shafiee, Simons, Simons, Simons, Singh, Sundahl, Touw, Trott, Vanden Berghe, Vanden Berghe, Vandevyver, Vane, Vanhaesebroeck, Verschuuren, Vettorazzi, Wang, Werkstrom   +61 more
core   +2 more sources

Non-Covalent Interactions in Triglycerides: Vaporisation Thermodynamics for Quantification of Dispersion Forces

Thermo, 2022
Qualitatively, the non-covalent interactions are well-known and help to explain many phenomena in chemistry and biochemistry. Quantitatively, determination of strength this force is a challenging task.
Sergey P. Verevkin, Ruslan N. Nagrimanov
doaj   +1 more source

Functional supramolecular tetrathiafulvalene-based films with mixed valences states [PDF]

, 2016
Tetrathiafulvalene molecules substituted with a carboxylic acid group (TTFCOOH) were bound as redox-active moieties into a poly(4-vinyl pyridine) (P4VP) skeleton through non-covalent interactions (hydrogen bonds). The aspect of the resulting P4VP-TTFCOOH
Amabilino, David B., González Campo, Arántzazu, Gómez Rodríguez, Andrés, Puigmartí Luis, Josep, Riba Moliner, Marta   +4 more
core   +2 more sources

Aromatic‐Carbonyl Interactions as an Emerging Type of Non‐Covalent Interactions

Advanced Science
Aromatic‐carbonyl (Ar···C═O) interactions, attractive interactions between the arene plane and the carbon atom of carbonyl, are in the infancy as one type of new supramolecular bonding forces.
Chaowei Yin, Hebo Ye, Yu Hai, Hanxun Zou, Lei You   +4 more
doaj   +1 more source

Long-range repulsive interaction between TTF molecules on a metal surface induced by charge transfer

, 2007
The low-coverage adsorption of a molecular electron donor, tetrathiafulvalene, on Au(111) is characterized by the spontaneous formation of superlattice of monomers, whose spacing exceeds the equilibrium distance of non-covalent interactions and depends ...
B. Diu, I. Fernandez-Torrente, J. Fraxedas, J. Fraxedas, J. I. Pascual, K. J. Franke, N. Lorente, S. Monturet   +7 more
core   +3 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

NEDD8 Deamidation Inhibits Cullin RING Ligase Dynamics

Frontiers in Immunology, 2021
Cullin-RING ligases (CRLs) are a significant subset of Ubiquitin E3 ligases that regulate multiple cellular substrates involved in innate immunity, cytoskeleton modeling, and cell cycle.
Priyesh Mohanty, Kiran Sankar Chatterjee, Ranabir Das   +2 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Molecular Recognition of SARS-CoV-2 Mpro Inhibitors: Insights from Cheminformatics and Quantum Chemistry

Molecules
The SARS-CoV-2 main protease (Mpro), essential for viral replication, remains a prime target for antiviral drug design against COVID-19 and related coronaviruses.
Adedapo Olosunde, Xiche Hu
doaj   +1 more source

QTAIM analysis dataset for non-covalent interactions in furan clusters

Data in Brief, 2022
Furan clusters are very important to understand the dynamics and properties of the furan solvent. They can be used combined with quantum cluster equilibrium theory to theoretically determine the thermodynamics properties of the furan solvent.
Alhadji Malloum, Jeanet Conradie
doaj   +1 more source