Results 51 to 60 of about 12,679,354 (288)

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Comparison of Non-Covalent and Covalent Interactions between Lactoferrin and Chlorogenic Acid

Foods
Adding polyphenols to improve the absorption of functional proteins has become a hot topic. Chlorogenic acid is a natural plant polyphenol with anti-inflammatory, antioxidant, and anticancer properties.
Zekun Li, Majida Al-Wraikat, Changchun Hao, Yongfeng Liu   +3 more
doaj   +1 more source

Changes in advanced protein structure during dense phase carbon dioxide induced gel formation in golden pompano surimi correlate with gel strength

Frontiers in Sustainable Food Systems, 2023
Changes in protein structure are closely related to gel strength. Dense phase carbon dioxide (DPCD) treatment is an excellent non-thermal food processing method that can be used to induce gel formation in surimi.
Weiwen Duan, Hui Qiu, Kyi Kyi Htwe, Shuai Wei, Yang Liu, Zefu Wang, Qinxiu Sun, Zongyuan Han, Qiuyu Xia, Shucheng Liu, Shucheng Liu, Shucheng Liu   +11 more
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Non-covalent interactions of heme with SymmDock server predicted TPO WT HD, TPO MT1 HD, and TPO MT2 HD.

, 2023
Non-covalent interactions of heme with SymmDock server predicted TPO WT HD, TPO MT1 HD, and TPO MT2 HD.
Rumana Mahtarin (9286701), Imrul Shahriar (9513239), Syed Saleheen Qadri (16973496), Mst. Noorjahan Begum (16814534), Sinthyia Ahmed (7347257), Md. Waseque Mia (16973493), Kaiissar Mannoor (3361070), Firdausi Qadri (89170), Shekh Rezwan Hossain (16973490), Sharif Akhteruzzaman (4731408)   +9 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Non-Covalent Interactions in Triglycerides: Vaporisation Thermodynamics for Quantification of Dispersion Forces

Thermo, 2022
Qualitatively, the non-covalent interactions are well-known and help to explain many phenomena in chemistry and biochemistry. Quantitatively, determination of strength this force is a challenging task.
Sergey P. Verevkin, Ruslan N. Nagrimanov
doaj   +1 more source

Tuning the stacking behaviour of a 2D covalent organic framework through non-covalent interactions [PDF]

, 2017
Two-dimensional covalent organic frameworks (COFs) are crystalline porous materials composed of organic building blocks that are connected via covalent bonds within their layers, but through non-covalent interactions between the layers.
Dinnebier, R. E., Duppel, V., Germann, L. S., Vyas, V. S., Stegbauer, L., L. Stegbauer, Gottschling, K., V. Duppel, K. Kern, B. V. Lotsch, Gutzler, R., Lotsch, B. V., F. Haase, R. E. Dinnebier, Kern, K., R. Gutzler, L. S. Germann, Haase, F., K. Gottschling, V. S. Vyas   +19 more
core   +1 more source

Non-Covalent Interactions Atlas Benchmark Data Sets 4: σ-Hole Interactions [PDF]

, 2022
The SH250×10 dataset presented here extends the Non-Covalent Interactions Atlas database (www.nciatlas.org) to complexes bound by σ-hole interactions – halogen, chalcogen and pnictogen bonds.
Kristian, Kříž, Jan, Řezáč
core   +2 more sources

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source