Results 71 to 80 of about 351,052 (293)

Multistep, sequential control of the trafficking and function of the multiple sulfatase deficiency gene product, SUMF1 by PDI, ERGIC-53 and ERp44. [PDF]

, 2008
Sulfatase modifying factor 1 (SUMF1) encodes for the formylglicine generating enzyme, which activates sulfatases by modifying a key cysteine residue within their catalytic domains. SUMF1 is mutated in patients affected by multiple sulfatase deficiency, a
Annunziata F., BALLABIO, ANDREA, Cosma M. P., Cozzolino M., FRALDI, ALESSANDRO, Lombardi A., MONTI, MARIA, PUCCI, PIETRO, Sitia R., Spampanato C., Zito E.   +10 more
core   +1 more source

Synthesis of multimetallic dendrimers through non-covalent interactions [PDF]

Dalton Trans., 2012
Hexa-ammonium functionalized Dendriphos ligands and mono-sulfonate functionalized metal complexes have been used as building blocks for the preparation of multimetallic dendritic assemblies. These metallodendrimers consist of a single metal centre surrounded by an oligocationic shell formed by the coordinated Dendriphos ligands and multiple associated ...
Snelders, D.J.M., Virboul, M.A.N., Kreiter, R., Versluis, C., van Koten, G., Klein Gebbink, R.J.M.   +5 more
openaire   +3 more sources

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Porphyrin Supramolecular Arrays Formed by Weakly Interacting Meso-Functional Groups on Au(111)

Molecules, 2019
The formation of a binary porphyrinic self-assembled system between meso-tetrakis(4-carboxyphenyl) porphyrin (TCPP) and meso-tetrakis(4-dimethyl amino) porphyrin (TDAP) was easily designed through non-covalent interactions in solution and adsorbed on a ...
Esteban Sánchez-Muñoz, José L. Gárate-Morales, Jacinto Sandoval-Lira, Julio M. Hernández-Pérez, Rocío Aguilar-Sánchez   +4 more
doaj   +1 more source

Investigation of atomic level patterns in protein--small ligand interactions. [PDF]

PLoS ONE, 2009
BACKGROUND: Shape complementarity and non-covalent interactions are believed to drive protein-ligand interaction. To date protein-protein, protein-DNA, and protein-RNA interactions were systematically investigated, which is in contrast to interactions ...
Ke Chen, Lukasz Kurgan
doaj   +1 more source

Protein surface mimetics: understanding how ruthenium tris(bipyridines) interact with proteins. [PDF]

, 2017
Protein surface mimetics achieve high affinity binding by exploiting a scaffold to project binding groups over a large area of solvent exposed protein surface to make multiple co-operative non-covalent interactions.
Arkin, Arkin, Azuma, Azzarito, Bayraktar, Blaskovich, Bull, Bushnell, Chiba, Crowley, Edfeldt, Erman, Filby, Fischer, Fletcher, Grünstein, Hamuro, Hewitt, Jewginski, Kang, Liu, Mallon, Margoliash, Margulies, McGovern, Mignani, Milroy, Muldoon, Ohkanda, Ohkanda, Park, Paul, Pelletier, Ponader, Renner, Saha, Schrader, Shaw, Shinoda, Simpson, Spencer, Takashima, Turrell, Uhlenheuer, Van Gelder, Verma, Vitello, Waring, Wei, Wilson, Wilson, Wilson, Yamaguchi, Yonetani, Zadmard, Zadmard, Zhou   +56 more
core   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

Guanidinium and spermidinium decavanadates: as small biomimetic models to understand non-covalent interactions between decavanadate and arginine and lysine side chains in proteins

Frontiers in Chemical Biology
During the last three decades, numerous investigations have been conducted on polyoxidovanadates to treat several illnesses and inhibit enzymes. Numerous decavanadate compounds have been proposed as potential therapies for Diabetes mellitus, Cancer, and ...
Luis F. Paredes-Pérez, Angel Mendoza, Amalia García-García, Laura E. Serrano-De la Rosa, Miguel A. Méndez-Rojas, Francisco J. Melendez, María Eugenia Castro, Enrique González-Vergara   +7 more
doaj   +1 more source

Assessment of the TCA functional in computational chemistry and solid-state physics

, 2015
We assess the Tognetti-Cortona-Adamo (TCA) generalized gradient approximation correlation functional [J. Chem. Phys. 128:034101 (2008)] for a variety of electronic systems.
Constantin, L. A., Cortona, P., Della Sala, F., Fabiano, E., Terentjevs, A.   +4 more
core   +3 more sources

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source