Results 71 to 80 of about 349,016 (294)

Investigation of atomic level patterns in protein--small ligand interactions. [PDF]

PLoS ONE, 2009
BACKGROUND: Shape complementarity and non-covalent interactions are believed to drive protein-ligand interaction. To date protein-protein, protein-DNA, and protein-RNA interactions were systematically investigated, which is in contrast to interactions ...
Ke Chen, Lukasz Kurgan
doaj   +1 more source

Protein surface mimetics: understanding how ruthenium tris(bipyridines) interact with proteins. [PDF]

, 2017
Protein surface mimetics achieve high affinity binding by exploiting a scaffold to project binding groups over a large area of solvent exposed protein surface to make multiple co-operative non-covalent interactions.
Arkin, Arkin, Azuma, Azzarito, Bayraktar, Blaskovich, Bull, Bushnell, Chiba, Crowley, Edfeldt, Erman, Filby, Fischer, Fletcher, Grünstein, Hamuro, Hewitt, Jewginski, Kang, Liu, Mallon, Margoliash, Margulies, McGovern, Mignani, Milroy, Muldoon, Ohkanda, Ohkanda, Park, Paul, Pelletier, Ponader, Renner, Saha, Schrader, Shaw, Shinoda, Simpson, Spencer, Takashima, Turrell, Uhlenheuer, Van Gelder, Verma, Vitello, Waring, Wei, Wilson, Wilson, Wilson, Yamaguchi, Yonetani, Zadmard, Zadmard, Zhou   +56 more
core   +1 more source

Synthesis of multimetallic dendrimers through non-covalent interactions [PDF]

Dalton Trans., 2012
Hexa-ammonium functionalized Dendriphos ligands and mono-sulfonate functionalized metal complexes have been used as building blocks for the preparation of multimetallic dendritic assemblies. These metallodendrimers consist of a single metal centre surrounded by an oligocationic shell formed by the coordinated Dendriphos ligands and multiple associated ...
Snelders, D.J.M., Virboul, M.A.N., Kreiter, R., Versluis, C., van Koten, G., Klein Gebbink, R.J.M.   +5 more
openaire   +3 more sources

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Porphyrin Supramolecular Arrays Formed by Weakly Interacting Meso-Functional Groups on Au(111)

Molecules, 2019
The formation of a binary porphyrinic self-assembled system between meso-tetrakis(4-carboxyphenyl) porphyrin (TCPP) and meso-tetrakis(4-dimethyl amino) porphyrin (TDAP) was easily designed through non-covalent interactions in solution and adsorbed on a ...
Esteban Sánchez-Muñoz, José L. Gárate-Morales, Jacinto Sandoval-Lira, Julio M. Hernández-Pérez, Rocío Aguilar-Sánchez   +4 more
doaj   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

The Use of Hammett Constants to Understand the Non-Covalent Binding of Aromatics

Computational and Structural Biotechnology Journal, 2012
Non-covalent interactions of aromatics are important in a wide range of chemical and biological applications. The past two decades have seen numerous reports of arene-arene binding being understood in terms Hammett substituent constants, and similar ...
Laura K. E. Hardebeck, Christina Bagwill, Michael Lewis, Selina Wireduaah   +3 more
doaj   +3 more sources

Accurate quantum-centric simulations of intermolecular interactions

Communications Physics
Modelling and simulating non-covalent interactions is challenging, as they are inherently weak, dynamic, and system-specific. Common predictive methods often require trading the accuracy for reducing the otherwise cumbersome computational cost.
Danil Kaliakin, Akhil Shajan, Fangchun Liang, Javier Robledo Moreno, Zhen Li, Abhishek Mitra, Mario Motta, Caleb Johnson, Abdullah Ash Saki, Susanta Das, Iskandar Sitdikov, Antonio Mezzacapo, Kenneth M. Merz Jr   +12 more
doaj   +1 more source

Guanidinium and spermidinium decavanadates: as small biomimetic models to understand non-covalent interactions between decavanadate and arginine and lysine side chains in proteins

Frontiers in Chemical Biology
During the last three decades, numerous investigations have been conducted on polyoxidovanadates to treat several illnesses and inhibit enzymes. Numerous decavanadate compounds have been proposed as potential therapies for Diabetes mellitus, Cancer, and ...
Luis F. Paredes-Pérez, Angel Mendoza, Amalia García-García, Laura E. Serrano-De la Rosa, Miguel A. Méndez-Rojas, Francisco J. Melendez, María Eugenia Castro, Enrique González-Vergara   +7 more
doaj   +1 more source

Protein chainmail variants in dsDNA viruses. [PDF]

, 2015
First discovered in bacteriophage HK97, biological chainmail is a highly stable system formed by concatenated protein rings. Each subunit of the ring contains the HK97-like fold, which is characterized by its submarine-like shape with a 5-stranded β ...
Chiou, Joshua, Zhou, Z Hong
core   +2 more sources