Results 41 to 50 of about 332,517 (295)
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
Spatial variability in the hyporheic zone refugium of temporary streams [PDF]
, 2011 A key ecological role hypothesized for the hyporheic zone is as a refugium that promotes survival of benthic invertebrates during adverse conditions in the surface stream.
Wood, PJ +5 more
core +1 more source
Journal of Applied Optics, 2020 For leather surface defects with the machine vision on-line detection, the image quality of some leather surface defects presented aeolotropism to the lighting direction, and the defects even failed to be shown, therefore the non-detection zone was formed.
WANG Xuekun +5 more
openaire +1 more source
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
Effect of non-uniform magnetic field on crystal growth by floating-zone method in microgravity
, 2001 The magnetic damping effect of the non-uniform magnetic field on the floating-zone crystal growth process in microgravity is studied by numerical simulation. The results show that the non-uniform magnetic field with designed configuration can effectively
胡文瑞 +2 more
core +1 more source
Islanding Detection Methods and Challenges for Distribution Generation: A Technological Review
IEEE AccessIslanding detection poses a significant technical challenge for the reliable operation of grid-connected photovoltaic (PV) systems, particularly as the deployment of distributed generation (DG) increases across modern power networks.
Farshad Aslani, Shuhui Li
doaj +1 more source
FEBS Letters, EarlyView.Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara +3 more
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Research and application of high-resolution micro-cylindrically focused logging tool
Frontiers in Earth Science, 2023 The unknown nature and complexity of non-uniform formations cause new difficulties and challenges to the accurate detection of electrical instruments in shallow formations.
Jigen Xia +12 more
doaj +1 more source