Results 61 to 70 of about 332,517 (295)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Islanding Detection of IEEE 13 Bus System Based on Sequence Components

International Transactions on Electrical Engineering and Computer Science, 2023
Islanding recognition in microgrids is crucial for enhancing power system safety and efficiency. This article presents a novel passive islanding recognition technique for grid integrated renewable Distributed Generation (DG) network.
P. Prudvi Raj
doaj  

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Analysis of recirculation zone and ignition position of non-premixed bluff-body for biogas mild combustion [PDF]

, 2013
Combustion ignition study is important due to the combustion process becoming more lean and efficient. This paper studied the recirculation zone and ignition location for the bluff-body non-premixed MILD burner with biogas used as fuel.
Noor, M. M., Yusaf, Talal, Wandel, Andrew P.   +2 more
core  

Fine-tuning structural RNA alignments in the twilight zone

, 2010
Bremges A, Schirmer S, Giegerich R. Fine-tuning structural RNA alignments in the twilight zone. BMC Bioinformatics. 2010;11(1): 222.Background A widely used method to find conserved secondary structure in RNA is to first construct a multiple sequence ...
Bremges Andreas, Schirmer, Stefanie, Stefanie Schirmer, Schirmer Stefanie, Bremges, Andreas ; https://orcid.org/, Robert Giegerich, Giegerich, Robert, Giegerich Robert, Andreas Bremges   +8 more
core   +1 more source

Correction: The Endocytic Adaptor Eps15 Controls Marginal Zone B Cell Numbers. [PDF]

, 2013
Eps15 is an endocytic adaptor protein involved in clathrin and non-clathrin mediated endocytosis. In Caenorhabditis elegans and Drosophila melanogaster lack of Eps15 leads to defects in synaptic vesicle recycling and synapse formation. We generated Eps15-
Eckhard Wolf, Pier Paolo Di Fiore, Treise, Irina, Helmut Fuchs, Offenhäuser, Nina, Simona Ronzoni, Thure Adler, Irina Treise, Betsholtz, Christer, Di Fiore, Pier Paolo, Busch, Dirk H., Martin Hrabě de Angelis, Lucano, Caterina, Amodio, Stefania, Adler, Thure, Caterina Lucano, Nina Offenhäuser, Betsholtz, Ingrid Holmberg, Rathkolb, Birgit, Pozzi, Benedetta, Daniela Castelletti, Castelletti, Daniela, Dirk H. Busch, Anna Sciullo, Ingrid Holmberg Betsholtz, Ronzoni, Simona, Christer Betsholtz, Stefano Casola, Birgit Rathkolb, Benedetta Pozzi, Sciullo, Anna, Fuchs, Helmut, Wolf, Eckhard, Gailus-Durner, Valérie, Hrabé de Angelis, Martin, Valérie Gailus-Durner, Casola, Stefano, Stefania Amodio   +37 more
core   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

A turning point chronology for the Euro-zone [PDF]

We propose a dating process for the business and growth Euro-zone cycles. This process is a result of a non parametric algorithm and diverse criteria assessment (duration, deepness, diffusion, synchronisation), as well as of “expert judgments” based on a
Marco Lo Duca, Jacques Anas, Monica Billio, Laurent Ferrara   +3 more
core  

Non-enzymatic Determination of Glucose in Artificial Urine Using 3D-µPADs through Silver Nanoparticles Formation

Indonesian Journal of Chemistry
Patients with diabetes often experience blood glucose fluctuations, making monitoring crucial. Traditional blood sampling methods pose risks of infection and pain. An alternative non-invasive approach using urine tests has been explored.
Ahmad Luthfi Fahmi, Kamila Rohadatul 'Aisy, Ika Oktavia Wulandari, Hermin Sulistyarti, Akhmad Sabarudin   +4 more
doaj   +1 more source

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

FEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel, Sam Bennett, Natalie Ehlinger, Nelson Cook, Katelyn Marvin, Caleb L. Lines, Sam Reyes, Brooke Kirby, Shawn M. Ellerbroek   +8 more
wiley   +1 more source