Results 121 to 130 of about 7,116,367 (259)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Self-determination, Non-domination, and Federalism
, 2008 This article summarizes the theory of federalism as non-domination Iris Marion Young began to develop in her final years, a theory of self-government that tried to recognize interconnectedness.
Jacob T. Levy
core +1 more source
Freedom as Non-Domination and Private Law's Autonomy
Law, Ethics and Philosophy, 2023 Leandro Martins Zanitelli
doaj +1 more source
Non-domination and Political Institutions: The Contested Concept of Republican Democracy [PDF]
Brazilian Political Science Review, 2015 Following the republican revival of the last few decades, the ideal of freedom as non-domination has become an important point of convergence among republican theorists, especially among those associated with neo-Roman republicanism. Furthermore, all neo-
Ricardo Silva
doaj
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Affirmative domination in graphs. [PDF]
, 2016 A function f : V → {−1, 0, 1} is an affirmative dominating function of graph G satisfying the conditions that for every vertex u such that f(u) = 0 is adjacent to at least one vertex v for which f(v) = 1 and P u∈N(v) f(u) ≤ 1 for every v ∈ V .
Chaitra, V., Chaluvaraju, B.
core
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
Commentary on Nielsen and Landes, 'Fighting Status Inequalities: Non-domination and Non-interference'. [PDF]
Public Health Ethics, 2016 McBride C.
europepmc +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source