Results 161 to 170 of about 6,604 (278)

Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer

open access: yesFEBS Open Bio, EarlyView.
CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee   +3 more
wiley   +1 more source

Supermassive gravitinos, dark matter, leptogenesis and flat direction baryogenesis

open access: yes, 2005
In general the gravitino mass and/or the soft supersymmetry breaking masses in the observable sector can be much larger than the TeV scale. Depending on the relation between the masses, new important channels for gravitino production in the early ...
Allahverdi, Rouzbeh   +4 more
core  

A general model for analysis of linear and hyperbolic enzyme inhibition mechanisms

open access: yesFEBS Open Bio, EarlyView.
We developed a general enzyme kinetic model that integrates these six basic inhibition mechanism onto a single one. From this model, we deduced a general enzyme kinetic equation that through modulation of simple parameters, γ (the relative inhibitor affinity for two binding sites) and β (the reactivity of the enzyme–substrate–inhibitor complex), is ...
Rafael S. Chagas, Sandro R. Marana
wiley   +1 more source

KARAKTERISTIK TULISAN NARASI FIKSI BERBAHASA ARAB MAHASISWA PENUTUR ASLI BAHASA INDONESIA

open access: yesBahasa dan Seni: Jurnal Bahasa, Sastra, Seni, dan Pengajarannya, 2011
This study is carried out to answer the research questions what are the characteristics of intrinsic elements, include is plot, character, and background   of the Arabic fictitious narrative writing of Indonesian language native students?
Nurhidayati Nurhidayati
doaj  

Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays

open access: yesFEBS Open Bio, EarlyView.
We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul   +3 more
wiley   +1 more source

Home - About - Disclaimer - Privacy