Results 211 to 220 of about 771,313 (279)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Recent advances in exploring the composition and evolution of the prokaryotic selenoproteome. [PDF]

Appl Environ Microbiol
Zhang Y, Wang S, Li H, Chen X.
europepmc   +1 more source

Ruthenium - A Non-essential Element that May Become Essential in Treating Chemoresistant Cancers.

Chimia, 2019
openaire   +2 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Seasonal Trace Element Contamination and Health Risk Assessment of the Mediterranean Limpet (<i>Patella caerulea</i>) from the Southern Black Sea. [PDF]

Life (Basel)
Gökkurt Baki O.
europepmc   +1 more source

Honey from Afyonkarahisar (Türkiye) exhibits low toxic-element burdens and distinct spatial elemental patterns. [PDF]

Sci Rep
Gümüştaş Ö, Acaroz U.
europepmc   +1 more source

Trace Elements and Depressive Symptoms in Coronary Artery Disease: A Systematic Review of Sparse and Predominantly Indirect Evidence. [PDF]

Int J Mol Sci
Baran JM, Waszak Z, Jarzębska J, Grusiecki D, Śmigielska M, Kochman W, Dziedzic EA.   +6 more
europepmc   +1 more source

Molecular Evolution and Mechanisms of Plants NRAMP Transporters in Response to Heavy Metal Stress. [PDF]

Plants (Basel)
Hao L, Chen J, Akami M, Ngueya CB, Samenoug DP, Tang H, Tang Q, Zheng Q, Peng Y, Zhang Y, Rong F, Wu J, Wang R, Zhao C, Wu X, Jiang W.   +15 more
europepmc   +1 more source

Biases and blind spots in the global research agenda on metallic pollution and bees. [PDF]

Naturwissenschaften
Martins FMT, de Azevedo CS, Rocha DG, de Melo DHA, Ribeiro MC, de Moura SAL.   +5 more
europepmc   +1 more source

Measuring the consultative stance among infant and early childhood mental health consultants. [PDF]

Infant Ment Health J
Miles E, Klopfenstein K, Wegner AK, Senehi N, Schlueter L.   +4 more
europepmc   +1 more source