Results 101 to 110 of about 30,049 (242)

Individual non-esterified fatty acids and incident atrial fibrillation late in life. [PDF]

open access: yesHeart, 2021
Pellegrini CN   +10 more
europepmc   +1 more source

Ti‐Doping Activates Adjacent Zr Sites in Bimetallic MOFs for Cooperative Phospholipid Removals in Human Biomonitoring

open access: yesAdvanced Science, EarlyView.
Ti‐doped Zr/Ti bimetallic MOFs activate neighboring Zr sites to selectively capture phospholipids from serum through cooperative interactions. In nontargeted screening, the material minimizes matrix interference, expands detectable feature coverage, and enables broad recovery of diverse chemical hazards, providing a powerful cleanup strategy for LC ...
Yanmin Liang   +5 more
wiley   +1 more source

Serum Non-Esterified Fatty Acids and Beta-Hydroxybutyrate in Dairy Cows with Retained Placenta [PDF]

open access: yesPakistan Veterinary Journal, 2011
The objective of this study was to establish serum concentrations of non-esterified fatty acids (NEFA) and beta-hydroxybutyrate (BHBA) in postpartum retained placenta in cattle.
Turan Civelek*, Ibrahim Aydin1, C. Cagri Cingi, Oktay Yilmaz2 and Mustafa Kabu
doaj  

Optimized Lipid Nanoparticles with Tail‐Modified Ionizable Lipids for Safer mRNA Delivery

open access: yesAdvanced Science, EarlyView.
Systematic engineering of hydrophobic tail architecture in vitamin B5‐derived ionizable lipids establishes a comprehensive structure–activity relationship framework for mRNA delivery. Combined lipidtail and formulation optimization identifies TM1‐OPT3‐C, a lipid nanoparticle platform that improves efficacy–safety balance through efficient mRNA delivery,
Seo‐Hyeon Bae   +27 more
wiley   +1 more source

Structural identification of novel bound 1-O-acylceramides in human stratum corneum and murine epidermis using mass spectrometry

open access: yesJournal of Analytical Science and Technology
The stratum corneum (SC)—the outermost layer of the skin—serves as a barrier that protects the body from environmental stress and prevents transdermal moisture loss.
Bae-Gon Kang   +5 more
doaj   +1 more source

Chemoselective Metabolomics via a Modular Reactivity‐Encoding Platform

open access: yesAdvanced Science, EarlyView.
Conventional LC–MS underrepresents numerous metabolites due to heterogeneous ionization efficiencies and matrix interference. Here, we introduce a modular reactivity‐encoding platform (MREP) comprising four alkyne‐tagged probes that selectively derivatize key functional groups, followed by unified click‐chemistry capture to eliminate matrix components ...
Xin Tao   +10 more
wiley   +1 more source

U Mass - Non-esterified fatty acids v1 [PDF]

open access: yes, 2019
Summary: This experiment measures serum and plasma concentrations of non-esterified fatty acids using a 96-well kit. The experiment involves a coupled reaction to measure non-esterified fatty acids (NEFA) which ultimately forms a purple product that absorbs light at 550nm. This allows the concentration of NEFA to be determined from the optical density
openaire   +1 more source

Targeted Degradation of Picornaviral 3C Protease via PROTACs Confers High Barrier to Viral Resistance and Broad‐Spectrum Antiviral Activity

open access: yesAdvanced Science, EarlyView.
This study reports D34 as the first PROTAC degrader that targets the 3C protease of picornaviruses. D34 effectively degrades EV71 3C protease via the ubiquitin‐proteasome pathway. More importantly, D34 exhibits a high resistance barrier and shows broad‐spectrum antiviral activity against multiple picornaviruses, highlighting its potential as a novel ...
Weilong Deng   +9 more
wiley   +1 more source

Fat supplement for dairy cows during early lactation – potentials, challenges, and risks – a meta-analysis

open access: yesJournal of Applied Animal Research
The most critical challenge in early lactation is to meet the increasing energy demand for milk production, which results in a negative energy balance (EB).
Saman Lashkari   +3 more
doaj   +1 more source

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