Results 91 to 100 of about 1,031,153 (395)

Lymphoid and CXCR4 Cell Targeted Lipid Nanoparticles Facilitate HIV‐1 Proviral DNA Excision

Advanced Healthcare Materials, EarlyView.
Advancements in ART improve HIV‐1 patient outcomes but are unable to eliminate latent viral DNA. To address this, CXCR4‐targeted lipid nanoparticles (T‐LNPs) for delivering CRISPR‐Cas9 to excise HIV‐1 DNA in infected cells are developed. These T‐LNPs achieve ≈60% HIV‐1 DNA excision efficacy in blood and splenic tissue, demonstrating promise for ...
Sudipta Panja, Lubaba A. Zaman, Chen Zhang, Milankumar Patel, Santhi Gorantla, Prasanta K. Dash, Howard E. Gendelman   +6 more
wiley   +1 more source

Abnormality of anxious behaviors and functional connectivity between the amygdala and the frontal lobe in maternally deprived monkeys

Brain and Behavior, 2023
Objective Anxious behaviors often occur in individuals who have experienced early adversity. Anxious behaviors can bring many hazards, such as social withdrawal, eating disorders, negative self‐efficacy, self‐injurious thoughts and behaviors, anxiety ...
Xiao‐Li Feng, Jiao‐Jian Wang, Jing Wu, Xiao‐Feng Ren, Hui Zhou, Si‐Yu Li, Jie Zhang, Sheng‐Hai Wang, Yun Wang, Zheng‐Fei Hu, Xin‐Tian Hu, Tian‐Zi Jiang   +11 more
doaj   +1 more source

Co-ordination of actions, visual perception, and inhibition in human and non-human primate development [PDF]

, 2000
The originality of Langer's approach to cognitive development (Langer, 1980, 1986) lies in the study of the pragmatic components (actions, object manipulations) of protologicomathematical and protophysical cognition before the age of 2.
Houdé, Pr O, Vauclair, Pr O
core  

Face processing limitation to own species in primates: a comparative study in brown capuchins, Tonkean macaques and humans [PDF]

, 2006
Most primates live in social groups which survival and stability depend on individuals' abilities to create strong social relationships with other group members. The existence of those groups requires to identify individuals and to assign to each of them
Bahrick, Bentin, Bruce, Campbell, Campbell, Carey, Dasser, de Haan, Diamond, Dufour, Fujita, Fujita, Goren, Gosset, Humphrey, Kay, Kelly, Kendrick, Kendrick, Kendrick, Kendrick, Kim, Kuwahata, Leder, Lutz, Maurer, Meissner, Myowa-Yamakoshi, Nelson, Nelson, Nemanic, Niedenthal, Odile Petit, Olivier Pascalis, Overman, Parr, Parr, Parr, Parr, Pascalis, Pascalis, Pascalis, Pascalis, Pascalis, Pascalis, Perrett, Phelps, Porter, Ridley, Sangrigoli, Simons, Tanaka, Thierry, Tomonaga, Tomonaga, Valentine, Valerie Dufour, van Hoof, Wright, Yin, Zola   +60 more
core   +4 more sources

Multifunctional Neural Probes Enable Bidirectional Electrical, Optical, and Chemical Recording and Stimulation In Vivo

Advanced Materials, EarlyView.
Convergence drawing is used to create flexible, microscale, multifunctional fiber‐based neural probes. Optimized materials selection enables individual devices to perform neural recording, electrical stimulation, optogenetics, fiber photometry, fluid delivery, and voltammetric neurotransmitter detection in rodents.
Nicolette Driscoll, Marc‐Joseph Antonini, Taylor M. Cannon, Pema Maretich, Greatness Olaitan, Valerie Doan Phi Van, Keisuke Nagao, Atharva Sahasrabudhe, Emmanuel Vargas Paniagua, Ethan J. Frey, Ye Ji Kim, Sydney Hunt, Melissa Hummel, Sanju Mupparaju, Alan Jasanoff, B. Jill Venton, Polina Anikeeva   +16 more
wiley   +1 more source

Nonhuman Primate IFITM Proteins Are Potent Inhibitors of HIV and SIV. [PDF]

PLoS ONE, 2016
Interferon-induced transmembrane (IFITM) proteins are potent antiviral factors shown to restrict the infection of many enveloped viruses, including HIV. Here we report cloning and characterization of a panel of nonhuman primate IFITMs.
Jordan Wilkins, Yi-Min Zheng, Jingyou Yu, Chen Liang, Shan-Lu Liu   +4 more
doaj   +1 more source

No monkey business: why studying NK cells in non-human primates pays off [PDF]

, 2013
Human NK (hNK) cells play a key role in mediating host immune responses against various infectious diseases. For practical reasons, the majority of the data on hNK cells has been generated using peripheral blood lymphocytes. In contrast, our knowledge of
Henoch Sangjoon Hong, James Michael Billingsley, Premeela eRajakumar, R Paul Johnson, R Paul Johnson, R. Keith eReeves   +5 more
core   +2 more sources

Generation of genetically engineered non‐human primate models of brain function and neurological disorders

American Journal of Primatology, 2018
Research with non‐human primates (NHP) has been essential and effective in increasing our ability to find cures for a large number of diseases that cause human suffering and death.
J. Park, Afonso C. Silva
semanticscholar   +1 more source

Exploring AAV‐Mediated Gene Therapy for Inner Ear Diseases: from Preclinical Success to Clinical Potential

Advanced Science, EarlyView.
Current preclinical studies of AAV‐mediated gene therapy explore different strategies based on the characteristics of inner ear diseases. For genetic hearing loss, approaches include the replacement of a “good gene,” removal of a “bad gene,” or direct correction of mutations through base editing.
Fan Wu, Wuhui He, Yun Xiao, Qiong Wu, Qing Zhang, Tiesong Zhang, Lei Xu, Xinyi Pang   +7 more
wiley   +1 more source

Increased expression of mesencephalic astrocyte-derived neurotrophic factor (MANF) contributes to synapse loss in Alzheimer’s disease

Molecular Neurodegeneration
Background The activation of endoplasmic reticulum (ER) stress is an early pathological hallmark of Alzheimer’s disease (AD) brain, but how ER stress contributes to the onset and development of AD remains poorly characterized.
Yiran Zhang, Xiusheng Chen, Laiqiang Chen, Mingting Shao, Wenzhen Zhu, Tingting Xing, Tingting Guo, Qingqing Jia, Huiming Yang, Peng Yin, Xiao-Xin Yan, Jiandong Yu, Shihua Li, Xiao-Jiang Li, Su Yang   +14 more
doaj   +1 more source