Results 91 to 100 of about 120,353 (299)
Advanced Science, EarlyView.This study shows that integrin receptor CD49a (Itga1 gene) is significantly upregulated in hyperactivated microglia and microglia‐specific knockdown of Itga1 rescues neuroinflammation and neurodegeneration in a chronic Parkinson's disease (PD) model by targeting PGAM5‐mediated mitochondrial dysfunction and NLRP3 activation. Targeted inhibition of CD49a
Huanpeng Lu +6 more
wiley +1 more source
Advanced Science, EarlyView.SETDB2 epigenetically represses Smad3 transcription by increasing H3K9me3 enrichment at its promoter, thereby mitigating podocyte dysfunction in DKD. The transcription factor TCF21 binds directly to the Setdb2 promoter and enhances its expression in podocytes. Abstract Podocyte dysfunction represents both an early pathological hallmark and a key driver
Lanfang Li +14 more
wiley +1 more source
Advanced Science, EarlyView.This study demonstrates meningeal lymphatic impairment associated with lung adenocarcinoma brain metastasis progression in both human patients and mouse models, establishes clinically applicable non‐invasive imaging biomarkers for quantitative analyzing mLV structure and function, and reveals mLVs as robust prognostic indicators and promising potential
Yuan Zhang +15 more
wiley +1 more source
90. Vector Biodistribution After Recombinant AAVrh10 Intrathecal Delivery in Non-Human Primates [PDF]
, 2016 Gwladys Gernoux +4 more
openalex +1 more source
Advanced Science, EarlyView.Magnetoelectric nanoparticles (MENPs) serve as externally controlled, MRI‐activated theranostic agents for targeted cancer therapy by inducing electric field‐based ablation in solid tumors. MENPs enable simultaneous precise tumor ablation and MRI signal modulation, allowing real‐time treatment monitoring and prediction of therapeutic outcomes with no ...
John Michael Bryant +28 more
wiley +1 more source
Comparative Single‐Cell Transcriptomic Atlas Reveals the Genetic Regulation of Reproductive Traits
Advanced Science, EarlyView.A cross‐species single‐cell transcriptomic atlas of reproductive and central nervous system tissues from sheep and humans reveals conserved cellular programs and regulatory networks that regulated fertility. Integration with GWAS for sheep lifetime average litter size identifies UNC5–SLIT–BMP signaling as a core pathway coordinating neuroendocrine ...
Bingru Zhao +8 more
wiley +1 more source
Resolving Conflicts within the Mind: Internal Warfare in Non-Human Primates
, 2022 M Huddleson
openalex +2 more sources
Advanced Science, EarlyView.6 nm iron oxide nanoparticles (IONP6) exhibit enzyme‐like activities that scavenge reactive oxygen and nitrogen species (RONS), including nitric oxide (NO). In stroke models, IONP6 promotes microglial polarization toward the M2 phenotype, reduces neuroinflammation, and improves neurological outcomes, offering a promising drug‐free approach to mitigate ...
Yilin Qi +12 more
wiley +1 more source
Non‐human primate fetal kidney transcriptome analysis indicates mammalian target of rapamycin (mTOR) is a central nutrient‐responsive pathway [PDF]
, 2006 Mark J. Nijland +4 more
openalex +1 more source