Incorporating the gut microbiota into models of human and non-human primate ecology and evolution.
American Journal of Physical Anthropology, 2016 The mammalian gut is home to a diverse community of microbes. Advances in technology over the past two decades have allowed us to examine this community, the gut microbiota, in more detail, revealing a wide range of influences on host nutrition, health ...
K. Amato
semanticscholar +1 more source
AAVR Expression is Essential for AAV Vector Transduction in Sensory Hair Cells
Advanced Science, EarlyView.Decreased sensitivity to AAV vector transduction in the outer hair cells (OHCs) of adult mice is primarily attributed to reduction of AAVR (Kiaa0319l; Au040320). Knockout of AAVR reduces AAV vector transduction efficiency in both inner hair cells (IHCs) and OHCs in neonatal mice.
Fan Wu +8 more
wiley +1 more source
RNA-Targeting CRISPR/CasRx system relieves disease symptoms in Huntington’s disease models
Molecular NeurodegenerationBackground HD is a devastating neurodegenerative disorder caused by the expansion of CAG repeats in the HTT. Silencing the expression of mutated proteins is a therapeutic direction to rescue HD patients, and recent advances in gene editing technology ...
Yingqi Lin +17 more
doaj +1 more source
Preliminary evidence of increased striatal dopamine in a nonhuman primate model of maternal immune activation. [PDF]
, 2019 Women exposed to a variety of viral and bacterial infections during pregnancy have an increased risk of giving birth to a child with autism, schizophrenia or other neurodevelopmental disorders.
Bauman, Melissa D +8 more
core +2 more sources
Gene Therapy, 2017 The present study was designed to characterize transduction of non-human primate brain and spinal cord with AAV5 viral vector after parenchymal delivery.
L. Samaranch +9 more
semanticscholar +1 more source
The Morphological, Behavioral, and Transcriptomic Life Cycle of Anthrobots
Advanced Science, EarlyView.DNA is thought to determine shape, behavior, and lifespan, with developmental plasticity reserved for stem cells, embryos, and species like amphibia. How much morphogenetic plasticity do adult somatic human cells exhibit? Anthrobots are a self‐organizing, motile synthetic living construct made of genetically normal human epithelial cells.
Gizem Gumuskaya +6 more
wiley +1 more source
A Study of Spontaneous Self-Injurious Behavior and Neuroimaging in Rhesus Macaques
ResearchNonsuicidal self-injury (NSSI) demonstrates escalating prevalence among adolescents as a maladaptive behavior characterized by deliberate self-harm, yet its neurobiological underpinnings remain elusive.
Ya-Li Zhang +30 more
doaj +1 more source
Brain‐Wide Spatiotemporally Distinct Traveling Waves Drive Anxiety‐Like Behaviors in Mice
Advanced Science, EarlyView.J.Liu et al. reveal the complete propagation dynamics of cortical traveling waves, from local circuitry initiation to long‐range propagation, and identify their functional relevance in modulating anxiety‐like behaviors and underlying cellular neuroplasticity in mice.
Jiaming Liu +15 more
wiley +1 more source
Supaglutide alleviates hepatic steatosis in monkeys with spontaneous MASH
Diabetology & Metabolic SyndromeBackground Glucagon-like peptide 1 (GLP-1) is an incretin hormone and plays an important role in regulating glucose homeostasis. GLP-1 has a short half-life due to degrading enzyme dipeptidyl peptidase-IV and rapid kidney clearance, which limits its ...
Qinghua Wang +9 more
doaj +1 more source
Primate malarias: Diversity, distribution and insights for zoonotic Plasmodium
One Health, 2015 Protozoans within the genus Plasmodium are well-known as the causative agents of malaria in humans. Numerous Plasmodium species parasites also infect a wide range of non-human primate hosts in tropical and sub-tropical regions worldwide.
Christina Faust, Andrew P. Dobson
doaj +1 more source