Results 101 to 110 of about 237,923 (376)

Strengths and challenges of longitudinal non-human primate neuroimaging

NeuroImage, 2021
Longitudinal non-human primate neuroimaging has the potential to greatly enhance our understanding of primate brain structure and function. Here we describe its specific strengths, compared to both cross-sectional non-human primate neuroimaging and ...
Xiaowei Song, Pamela García-Saldivar, Nathan Kindred, Yujiang Wang, Hugo Merchant, Adrien Meguerditchian, Yihong Yang, Elliot A. Stein, Charles W. Bradberry, Suliann Ben Hamed, Hank P. Jedema, Colline Poirier   +11 more
doaj  

An Evaluation of Twenty Years of EU Framework Programme-funded Immune-mediated Inflammatory Translational Research in Non-human Primates

Frontiers in Immunology, 2016
Ageing western societies are facing an increasing prevalence of chronic inflammatory and degenerative diseases for which often no effective treatments exist, resulting in increasing health care expenditure.
Krista Geraldine Haanstra, Margreet Jonker, Margreet Jonker, Bert A 't Hart, Bert A 't Hart   +4 more
doaj   +1 more source

Unraveling Neurodevelopment: Synergistic Effects of Intrinsic Genetic Programs and Extrinsic Environmental Cues

Advanced Science, EarlyView.
Overview of the regulation of intrinsic and extrinsic signals during neurodevelopment. Intrinsic genetic signals from NSCs, in conjunction with cues from microglia and blood vessels, collaboratively regulate the proliferation of NSCs, their fate determination, synaptogenesis, synaptic pruning, neuronal survival, and death, as well as communication ...
Yanyan Wang, Shukui Zhang, Huiyang Jia, Fen Ji, Jianwei Jiao   +4 more
wiley   +1 more source

Intranasal delivery of small extracellular vesicles reduces the progress of amyotrophic lateral sclerosis and the overactivation of complement-coagulation cascade and NF-ĸB signaling in SOD1 G93A mice

Journal of Nanobiotechnology
Amyotrophic lateral sclerosis (ALS) is a fatal disease characterized by progressive motoneuron degeneration, and effective clinical treatments are lacking.
Jinrui Zhou, Fuxiang Li, Bin Jia, Zicong Wu, Zhonghai Huang, Meiting He, Huandi Weng, Kwok-Fai So, Wenrui Qu, Qing-Ling Fu, Libing Zhou   +10 more
doaj   +1 more source

VDAC in Retinal Health and Disease

Biomolecules
The retina, a tissue of the central nervous system, is vital for vision as its photoreceptors capture light and transform it into electrical signals, which are further processed before they are sent to the brain to be interpreted as images. The retina is
Ying Xu, Shanti R. Tummala, Xiongmin Chen, Noga Vardi   +3 more
doaj   +1 more source

Characterization of gut microbiome in a captive colony of marmosets

Berliner und Münchener Tierärztliche Wochenschrift, 2020
Although the microbiome signatures in primates are more similar to humans in comparison to microbiome of mice and rats, the study of microbiome in primate models and particularly in non-human primates such as the common marmoset (Callithrix jacchus) are ...
I J Knorr, L Benga, L Peitzmann, E Engelhardt, W Benten, C Gougoula, P Petzsch, K Köhrer, M Sager   +8 more
doaj   +1 more source

Examining Representational Similarity in ConvNets and the Primate Visual Cortex [PDF]

arXiv, 2016
We compare several ConvNets with different depth and regularization techniques with multi-unit macaque IT cortex recordings and assess the impact of the same on representational similarity with the primate visual cortex. We find that with increasing depth and validation performance, ConvNet features are closer to cortical IT representations.
arxiv  

Inhibition of Ferroptosis Delays Aging and Extends Healthspan Across Multiple Species

Advanced Science, EarlyView.
This study identifies ferroptosis as a key driver of cellular senescence, with its inhibition delaying aging and extending healthspan across species. During senescence, ferroptosis worsens, increasing oxidative stress and lipid peroxidation, which accelerate aging.
Hai‐Jun Fu, Xing‐Yue Zhou, Da‐Lian Qin, Qan Qiao, Qiao‐Zhi Wang, Shi‐Ying Li, Yun‐Fei Zhu, Ya‐Ping Li, Jiang‐Min Zhou, Hui Cai, Fei‐Hong Huang, Lu Yu, Long Wang, An‐Guo Wu, Jian‐Ming Wu, Xiao‐Gang Zhou   +15 more
wiley   +1 more source

Nonhuman Primate Models of Respiratory Disease: Past, Present, and Future. [PDF]

, 2017
The respiratory system consists of an integrated network of organs and structures that primarily function for gas exchange. In mammals, oxygen and carbon dioxide are transmitted through a complex respiratory tract, consisting of the nasal passages ...
Miller, Lisa, Pinkerton, Kent, Royer, Christopher, Schelegle, Edward   +3 more
core   +1 more source

Magnetic‐Guided Delivery of Antisense Oligonucleotides for Targeted Transduction in Multiple Retinal Explant and Organoid Models

Advanced Science, EarlyView.
Magnetic field‐guided MNP@ATR‐ASO nanocomplexes facilitate the targeted delivery of ASOs to ganglion cells or photoreceptors within retinal explants, thereby enhancing the efficacy of ASOs in correcting pre‐mRNA splicing abnormalities. Furthermore, the nanocomplexes improve ASO penetration and delivery in human retinal and inner ear organoid models ...
Xiuhong Ye, Sihui Chen, Wei Xiong, Fan Wang, Hon Fai Chan, Haocheng Lai, Xiangyu Guo, Tingting Yang, Shuhao Shen, Hang Chen, Wenxuan Wang, Guei‐Sheung Liu, Yonglong Guo, Jiansu Chen   +13 more
wiley   +1 more source