Results 191 to 200 of about 237,923 (376)

Nanostructured drug delivery systems for posterior segment eye diseases: Strategies to defy ocular barriers

BMEMat, EarlyView.
Efficient drug delivery to the posterior segment of the eye has long been a challenging issue due to the complex ocular barriers. The review focuses on the promise held by nanoplatforms for barrier penetration and the key mechanisms involved, also highlighting their advantages in achieving efficient drug delivery and superior treatment of PSEDs ...
Yifan Shen, Ying Yao, Yan Zhang, Xinyu Shi, Ling Bai, Yang Zhong, Yan Zhang, Kun Zhang   +7 more
wiley   +1 more source

Brain‐Wide Neuroregenerative Gene Therapy Improves Cognition in a Mouse Model of Alzheimer's Disease

Advanced Science
Alzheimer's disease (AD) is a progressive and irreversible brain disorder with extensive neuronal loss in the neocortex and hippocampus. Current therapeutic interventions focus on the early stage of AD but lack effective treatment for the late stage of ...
Zheng Wu, Liang Xu, Yu Xie, Abhijeet Sambangi, Shreya Swaminathan, Zifei Pei, Wenyu Ji, Zeru Li, Yaowei Guo, Zhifei Li, Gong Chen   +10 more
doaj   +1 more source

XENOGENEIC THYMIC TRANSPLANTATION IN A PIG-TO-NON-HUMAN-PRIMATE MODEL

, 1998
Aqin Wu, N. F. Esnaola, K. Yamada, M. Awwad, A. Shimizu, C. Huang, J. Wain, Yan Zhao, D. Neville, D.K.C. Cooper, M. Sykes, D. H. Sachs   +11 more
openalex   +1 more source

Cerebral volumetric asymmetries in non-human primates: A magnetic resonance imaging study [PDF]

, 2001
Dawn L. Pilcher, Elizabeth A. D. Hammock, William D. Hopkins   +2 more
openalex   +1 more source

Development of Carborane‐Based Halogenated Naphthyridinone‐Analoga as Cannabinoid Receptor Type 2 (CB2R) Ligands

ChemMedChem, Accepted Article.
The cannabinoid receptor type 2 (CB2R) is overexpressed under pathological conditions. PET is a suitable non‐invasive imaging technique for diagnosing disease states, but requires a radiotracer that binds to CB2R with high affinity and selectivity. Currently, there is no suitable candidate routinely used in the clinics.
Lea Ueberham, Winnie Deuther-Conrad, Peter Lönnecke, Aleksandr Kazimir, Evamarie Hey-Hawkins   +4 more
wiley   +1 more source

GRAFT VASCULAR DISEASE (GVD) IN NON HUMAN PRIMATES: QUANTITATION OF CHANGES IN ARTERIAL AUTO- AND ALLOGRAFTS BY INTRAVASCULAR ULTRASOUND(IVUS)

, 1998
J. Gummert, T. Ikonen, N. Briffa, Y. Honda, J. Perlroth, M. Hayase, B. Hausen, M E Billingham, C. Barlow, R. C. Robbins, P. G. Yock, R. E. Morris   +11 more
openalex   +1 more source

Characterization of the response to myelin basic protein in a non human primate model for multiple sclerosis [PDF]

, 2001
Antonio Uccelli, Debora Giunti, Gianluigi Mancardi, Francesco Caroli, Marialuce Fiorone, Marco Seri, Stephen L. Hauser, Claude P. Genain   +7 more
openalex   +1 more source

Confirmation of Fixed Quarterly Riliprubart Regimen in Patients with Cold Agglutinin Disease Using Population PK/PD and Exposure‐Response Analyses

Clinical Pharmacology &Therapeutics, EarlyView.
Riliprubart is a second‐generation, humanized immunoglobulin G4 that inhibits only the activated form of the C1s component of the proximal classical complement pathway. The clinical studies of riliprubart conducted thus far for the treatment of cold agglutinin disease (CAD), a rare autoimmune disease, include a Phase 1 first‐in‐human study in healthy ...
Timothy Chow, Marek Wardecki, Michael Storek, Nancy Wong   +3 more
wiley   +1 more source

Immune responses toC. trachomatis infections in a non-human primate model

, 1996
Dorothy L. Patton
openalex   +1 more source

LEUKOTOXIC ACTIVITY OF ACTINOBACILLUS ACTINOMYCETEMCOMITANS ISOLATED FROM HUMAN AND NON-HUMAN PRIMATES [PDF]

, 2001
Francisca Lúcia de Lima, Flávio Furtado de Farias, Patrícia Cota Campos, Antônio Helvécio Tótola, Carlos Alberto Pereira Tavares, José Eustáquio Costa, Luiz de Mácêdo Farias, Maria Auxiliadora Roque de Carvalho   +7 more
openalex   +1 more source