Results 21 to 30 of about 1,031,153 (395)

Cytokine expression in malaria-infected non-human primate placentas [PDF]

, 2012
Malaria parasites are known to mediate the induction of inflammatory immune responses at the maternal-foetal interface during placental malaria (PM) leading to adverse consequences like pre-term deliveries and abortions.
Barasa, M., Barasa, M. B. O., Gicheru, M. M., Kagasi, E. A., Namulanda, F. B. M., Ng'ang'a, Z. W., Okoth, J. M., Ozwara, S. H., Sowayi, G. A.   +8 more
core   +9 more sources

A Specific Mini‐Intrabody Mediates Lysosome Degradation of Mutant Huntingtin

Advanced Science, 2023
Accumulation of misfolded proteins leads to many neurodegenerative diseases that can be treated by lowering or removing mutant proteins. Huntington's disease (HD) is characterized by the intracellular accumulation of mutant huntingtin (mHTT) that can be ...
Caijuan Li, Yingqi Lin, Yizhi Chen, Xichen Song, Xiao Zheng, Jiawei Li, Jun He, Xiusheng Chen, Chunhui Huang, Wei Wang, Jianhao Wu, Jiaxi Wu, Jiale Gao, Zhuchi Tu, Xiao‐Jiang Li, Sen Yan, Shihua Li   +16 more
doaj   +1 more source

LY-CoV555, a rapidly isolated potent neutralizing antibody, provides protection in a non-human primate model of SARS-CoV-2 infection

bioRxiv, 2020
SARS-CoV-2 poses a public health threat for which therapeutic agents are urgently needed. Herein, we report that high-throughput microfluidic screening of antigen-specific B-cells led to the identification of LY-CoV555, a potent anti-spike neutralizing ...
Bryan E. Jones, P. Brown-Augsburger, Kizzmekia S. Corbett, Kathryn Westendorf, J. Davies, T. Cujec, C. Wiethoff, J. Blackbourne, B. Heinz, Denisa Foster, R. Higgs, D. Balasubramaniam, Lingshu Wang, Roza Bidshahri, Lucas Kraft, Yuri Hwang, Stefanie Žentelis, Kevin R. Jepson, R. Goya, Maia A. Smith, D. W. Collins, Samuel J. Hinshaw, Sean A. Tycho, Davide Pellacani, Ping Xiang, Krithika Muthuraman, S. Sobhanifar, Marissa H. Piper, Franz J. Triana, J. Hendle, A. Pustilnik, A. Adams, Shawn J. Berens, R. Baric, David R. Martinez, R. Cross, T. Geisbert, V. Borisevich, O. Abiona, H. Belli, M. de Vries, Adil Mohamed, Meike Dittmann, M. Samanovic, M. Mulligan, J. Goldsmith, C. Hsieh, N. Johnson, D. Wrapp, J. McLellan, B. Barnhart, B. Graham, J. Mascola, C. Hansen, E. Falconer   +54 more
semanticscholar   +1 more source

Pathological insights from amyotrophic lateral sclerosis animal models: comparisons, limitations, and challenges

Translational Neurodegeneration, 2023
In order to dissect amyotrophic lateral sclerosis (ALS), a multigenic, multifactorial, and progressive neurodegenerative disease with heterogeneous clinical presentations, researchers have generated numerous animal models to mimic the genetic defects ...
Longhong Zhu, Shihua Li, Xiao-Jiang Li, Peng Yin   +3 more
doaj   +1 more source

Optimization of Milk Substitutes for the Artificial Rearing of Chinese Tree Shrews (Tupaia belangeri chinensis)

Animals, 2022
The Chinese tree shrew (Tupaia belangeri chinensis) has the potential to replace the use of non-human primates in biomedical research. To increase the availability of this species, we have undertaken the ambitious task of establishing inbred lines of the
Jia-Qi Chen, Qingyu Zhang, Dandan Yu, Rui Bi, Yuhua Ma, Yijiang Li, Long-Bao Lv, Yong-Gang Yao   +7 more
doaj   +1 more source

Tauopathy promotes spinal cord-dependent production of toxic amyloid-beta in transgenic monkeys

Signal Transduction and Targeted Therapy, 2023
Tauopathy, characterized by the hyperphosphorylation and accumulation of the microtubule-associated protein tau, and the accumulation of Aβ oligomers, constitute the major pathological hallmarks of Alzheimer’s disease.
Zhuchi Tu, Sen Yan, Bofeng Han, Caijuan Li, Weien Liang, Yingqi Lin, Yongyan Ding, Huiyi Wei, Lu Wang, Hao Xu, Jianmeng Ye, Bang Li, Shihua Li, Xiao-Jiang Li   +13 more
doaj   +1 more source

CRISPR/Cas9-mediated Knockout of KIFC1 Inhibits Proliferation and Induces Apoptosis of Cervical Cancer Cells

Zhongliu Fangzhi Yanjiu, 2023
Objective To investigate the functions of the KIFC1 gene in tumor cells and its effect on the proliferation of cervical cancer cells. Methods We designed sgRNAs targeting the KIFC1 gene and constructed a recombinant plasmid based on the pSpCas9 (BB)-2A ...
FAN Xiaojing, WEI Yalan, YE Zhoujie, ZHU Liping, WANG Xinrui   +4 more
doaj   +1 more source

Neuroimaging of Non-Human Primates [PDF]

The Open Neuroimaging Journal, 2011
Welcome to this special issue of the Open Neuroimaging Journal which focuses on neuroimaging studies of non-human primates (NHPs) as presented by leaders in the field. NHPs are important animal models because of their genetic, ontogenic, and physiological similarities to humans.
openaire   +3 more sources

Non-human primates and Leishmania immunity

Cytokine: X, 2020
In the context of infectious diseases, non-human primates (NHP) provide the best animal models of human diseases due to the close phylogenetic relationship and the similar physiology and anatomical systems. Herein, we summarized the contribution of NHP models for understanding the immunity to leishmaniases, which are a group of diseases caused by ...
Jérôme Estaquier, Jérôme Estaquier, Ricardo Silvestre, Morgane Picard, Vasco Rodrigues, Sonia André   +5 more
openaire   +3 more sources

The Situational Structure of Primate Beliefs [PDF]

, 2016
This paper develops the situational model of primate beliefs from the Prior-Lurz line of thought. There is a strong skepticism concerning primate beliefs in the analytic tradition which holds that beliefs have to be propositional and non-human animals do
Cheng, Tony
core   +1 more source