Results 21 to 30 of about 237,923 (376)

Optimization of Milk Substitutes for the Artificial Rearing of Chinese Tree Shrews (Tupaia belangeri chinensis)

Animals, 2022
The Chinese tree shrew (Tupaia belangeri chinensis) has the potential to replace the use of non-human primates in biomedical research. To increase the availability of this species, we have undertaken the ambitious task of establishing inbred lines of the
Jia-Qi Chen, Qingyu Zhang, Dandan Yu, Rui Bi, Yuhua Ma, Yijiang Li, Long-Bao Lv, Yong-Gang Yao   +7 more
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Tauopathy promotes spinal cord-dependent production of toxic amyloid-beta in transgenic monkeys

Signal Transduction and Targeted Therapy, 2023
Tauopathy, characterized by the hyperphosphorylation and accumulation of the microtubule-associated protein tau, and the accumulation of Aβ oligomers, constitute the major pathological hallmarks of Alzheimer’s disease.
Zhuchi Tu, Sen Yan, Bofeng Han, Caijuan Li, Weien Liang, Yingqi Lin, Yongyan Ding, Huiyi Wei, Lu Wang, Hao Xu, Jianmeng Ye, Bang Li, Shihua Li, Xiao-Jiang Li   +13 more
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CRISPR/Cas9-mediated Knockout of KIFC1 Inhibits Proliferation and Induces Apoptosis of Cervical Cancer Cells

Zhongliu Fangzhi Yanjiu, 2023
Objective To investigate the functions of the KIFC1 gene in tumor cells and its effect on the proliferation of cervical cancer cells. Methods We designed sgRNAs targeting the KIFC1 gene and constructed a recombinant plasmid based on the pSpCas9 (BB)-2A ...
FAN Xiaojing, WEI Yalan, YE Zhoujie, ZHU Liping, WANG Xinrui   +4 more
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Bioactive Peptides and Proteins from Centipede Venoms

Molecules, 2022
Venoms are a complex cocktail of biologically active molecules, including peptides, proteins, polyamide, and enzymes widely produced by venomous organisms.
Yalan Han, Peter Muiruri Kamau, Ren Lai, Lei Luo   +3 more
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Myeloablative irradiation in non‐human primates [PDF]

Journal of Medical Primatology, 2009
AbstractPurpose  We used total body irradiation (TBI) as conditioning for cord blood transplantation studies in pigtailed macaques. In these studies, different doses of TBI were explored to obtain optimal myelosuppression with acceptable radiation‐related side effects.Methods  Four macaques received TBI ranging from 800 to 1320 cGy, followed by ...
Brian C. Beard, Brent L. Wood, Hans-Peter Kiem, Hans-Peter Kiem, Korashon L. Watts   +4 more
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Conserved presence of G-quadruplex forming sequences in the Long Terminal Repeat Promoter of Lentiviruses [PDF]

, 2017
G-quadruplexes (G4s) are secondary structures of nucleic acids that epigenetically regulate cellular processes. In the human immunodeficiency lentivirus 1 (HIV-1), dynamic G4s are located in the unique viral LTR promoter.
A Ayouba, A Henderson, A Rambaut, AK Todd, AM Fleming, AN Lane, AR Haeusler, B Berkhout, B Zhou, BF Keele, D Piekna-Przybylska, D Qu, D Rhodes, D Sen, DJ Patel, E Tosoni, EA Raiber, F Barre-Sinoussi, F Benachenhou, F Bibollet-Ruche, F Heuverswyn Van, F Turrini, G Biffi, GE Crooks, IT Holder, J Felsenstein, J Norseen, J Qiu, J Song, J Yamaguchi, JE Clements, JF Fisette, JP Taylor, K Tamura, K Tluckova, KA Jones, LA Pereira, M Fry, M Metifiot, M Sala, M Scalabrin, MA Larkin, N Maizels, ND Perkins, NH Campbell, P Fratta, P Ivanov, P Murat, P Sket, R Perrone, R Perrone, R Perrone, R Perrone, RC Edgar, RC Gallo, RJ Gifford, S Amrane, S Artusi, S Artusi, S Balasubramanian, S Bhatia, S Broos, S Burge, S Pohlmann, SE Tong-Starksen, SR Wang, SR Wang, Y Wang   +67 more
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Multisensory Integration in Self Motion Perception [PDF]

, 2016
Self motion perception involves the integration of visual, vestibular, somatosensory and motor signals. This article reviews the findings from single unit electrophysiology, functional and structural magnetic resonance imaging and psychophysics to ...
Andersen, Angelaki, Avillac, Avillac, Barany, Barlow, Barlow, Beer, Beintema, Beintema, Ben Hamed, Benson, Biagi, Billington, Bottini, Bottini, Bradley, Brandt, Brandt, Bremmer, Bremmer, Bremmer, Bremmer, Bremmer, Bremmer, Bremmer, Britten, Butler, Cardin, Chen, Chen, Chen, Claeys, Cohen, Coniglio, Crane, Crane, Cuturi, Cuturi, De Winkel, Deutschländer, Dieterich, Dieterich, Dieterich, Dieterich, Duffy, Duffy, Duffy, Duffy, Duhamel, Dukelow, Eickhoff, Erickson, Fasold, Fattori, Ferrè, Ferrè, Ferrè, Ferrè, Fetsch, Fetsch, Frank, Frank, Frank, Galletti, Galletti, Galletti, Galletti, Gamberini, Gibson, Grabherr, Grantham, Greenlee, Gu, Gu, Gu, Gu, Gu, Guldin, Hitier, Holten, Huang, Huk, Ionta, Kaliuzhna, Kaminiarz, Kitagawa, Kleinschmidt, Koenderink, Kommerell, Konkle, Konkle, Kontsevich, Körding, Lackner, Lappe, Lappe, Lappe, Lappe, Lappe, Lobel, Lopez, Lopez, MacNeilage, MacNeilage, Mather, Mergner, Mergner, Morgan, Morris, Morrone, Ni, Orban, Page, Perrone, Pfeiffer, Pfeiffer, Pfeiffer, Pitzalis, Pitzalis, Priesol, Probst, Prsa, Riecke, Roach, Schlack, Seemungal, Seno, Sereno, Sereno, Shenoy, Shu, Smith, Sommer, Sperry, Stephan, Sunaert, Sutherland, Takahashi, Uesaki, Upadhyay, Valko, Vallar, Van den Berg, von Holst, Wall, Wallace, Warren, Warren, Watanabe, Wexler, Yu, Zhang, Zhang, zu Eulenburg   +154 more
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An Open Resource for Non-human Primate Optogenetics

Neuron, 2020
Optogenetics has revolutionized neuroscience in small laboratory animals, but its effect on animal models more closely related to humans, such as non-human primates (NHPs), has been mixed. To make evidence-based decisions in primate optogenetics, the scientific community would benefit from a centralized database listing all attempts, successful and ...
Alessandra Angelucci, Michael Ortiz-Rios, Michael Ortiz-Rios, Daniel J. O’Shea, Philip N. Sabes, Sorin Pojoga, Spencer C Chen, Stefan Treue, James J. DiCarlo, Lauri Nurminen, Kazutaka Maeda, Janina Hüer, Evan D. Remington, Selina S. Solomon, Marc Alwin Gieselmann, Cambria Revsine, Cambria Revsine, Michael C. Schmid, Michael C. Schmid, Mark A.G. Eldridge, Michele A. Basso, Rishi Rajalingham, Michael N. Shadlen, Ilya E. Monosov, Michal G. Fortuna, Wim Vanduffel, Wim Vanduffel, Martin O. Bohlen, Adam Kohn, Yoland Smith, Hala G. El-Nahal, Charu Ramakrishnan, Ariana R. Andrei, Eghbal A. Hosseini, Roger Janz, Amir Aschner, Shiming Tang, Anna W. Roe, Anna W. Roe, Mykyta M. Chernov, Carsten Klein, Daniel L. Albaugh, John H. R. Maunsell, Yuzhi Chen, James Cavanaugh, John L. Spudich, Christopher I. Petkov, Sébastien Tremblay, Samantha Debes, William R. Stauffer, Roberto Calcedo, Leah Acker, Seth W. Egger, Eyal Seidemann, Ji Dai, Adriana Galván, Richard C. Saunders, Alexander Thiele, Robert Desimone, Hidetoshi Amita, Xing Hu, Rufin Vogels, Alexander Gail, Ken-ichi Inoue, Kohitij Kar, Valentin Dragoi, Julio Martinez-Trujillo, Matthew P. Whitmire, Andrew M. Clark, Azadeh Yazdan-Shahmorad, Azadeh Yazdan-Shahmorad, Frederick Federer, Masahiko Takada, Mehrdad Jazayeri, Diego Mendoza-Halliday, Krishna V. Shenoy, Francesco Fabbrini, Puiu F. Balan, Roberto A. Gulli, Misako Komatsu, Karl Deisseroth, Christopher R. Fetsch, David L. Sheinberg, Robert H. Wurtz, Hansjörg Scherberger, Wolfram Schultz, Okihide Hikosaka, Michael J. Caiola, Marc A. Sommer, Michael L. Platt, Naotaka Fujii, Yann Suhan Senova, Supriya Ghosh, Arash Afraz, Masayuki Matsumoto, Ross S. Muers, Robert M. Friedman, Haoran Xu, Niansheng Ju, Rundong Jiang, Giacomo Benvenuti, Thomas Wichmann, Stéphane Palfi, Caitlin R. Siu   +103 more
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Aberrant splicing of mutant huntingtin in Huntington's disease knock-in pigs

Neurobiology of Disease, 2023
Huntington's disease (HD) is an autosomal-dominant inherited neurodegenerative disease caused by a CAG repeat expansion in exon1 of the huntingtin gene (HTT).
Huichun Tong, Tianqi Yang, Li Liu, Caijuan Li, Yize Sun, Qingqing Jia, Yiyang Qin, Laiqiang Chen, Xianxian Zhao, Gongke Zhou, Sen Yan, Xiao-Jiang Li, Shihua Li   +12 more
doaj  

Bioactive Peptides and Proteins from Wasp Venoms

Biomolecules, 2022
Wasps, members of the order Hymenoptera, use their venom for predation and defense. Accordingly, their venoms contain various constituents acting on the circulatory, immune and nervous systems.
Lei Luo, Peter Muiruri Kamau, Ren Lai
doaj   +1 more source