Results 71 to 80 of about 120,353 (299)

Nanoparticle Adjuvant Design Enhances Germinal Center Responses Targeting Conserved Subdominant Epitopes for Pan‐Coronavirus Vaccine Development

Advanced Science, EarlyView.
Current SARS‐CoV‐2 vaccines generate short‐lived, strain‐specific immunity. A polymeric TLR7 agonist nanoparticle (TLR7‐NP) adjuvant enhances lymph node targeting and promotes early and sustained germinal center responses toward conserved S2 epitopes of the spike protein.
Sijin Huang, Kanella M. Cohen, Liqiang Chen, Xiaowo Kang, Chang Liu, Megan E. Demouth, Wenxia Jiang, Alexander R. Maldeney, Rong Tong, Zunlong Ke, Kartik Chandran, Wei Luo, Qian Yin   +12 more
wiley   +1 more source

The knockout of Moesin leads to excess microglia-mediated synaptic pruning and impairs social novelty in a mouse model

Cell Reports
Summary: Genome-wide association studies (GWASs) have implicated a noncoding antisense RNA designated as MSNP1AS (Moesin pseudogene 1, antisense) in susceptibility to autism spectrum disorders (ASDs).
Wanjing Lai, Junlin Chen, Hongyao Zhu, Yunbo Jiang, Yimei Niu, Qingpei Chen, Zhihua Luo, Yu Hu, Li Fang, Yaxuan Wang, Youqiang Song, Charlly Kao, Jubao Duan, Kwok-Fai So, Hakon Hakonarson, Li Zhang, Kai Wang, Lingling Shi   +17 more
doaj   +1 more source

African Non-Human Primates Host Diverse Enteroviruses

PLOS ONE, 2017
Enteroviruses (EVs) belong to the family Picornaviridae and are responsible for mild to severe diseases in mammals including humans and non-human primates (NHP). Simian EVs were first discovered in the 1950s in the Old World Monkeys and recently in wild chimpanzee, gorilla and mandrill in Cameroon.
Mombo, Illich, Lukashev, Alexander, Bleicker, Tobias, Brünink, Sebastian, Berthet, Nicolas, Maganga, Gael, Patrick, Durand, Arnathau, Céline, Boundenga, Larson, Ngoubangoye, Barthélémy, Boué, Vanina, Liegeois, Florian, Ollomo, Benjamin, Prugnolle, Franck, Drexler, Jan, Drosten, Christian, Renaud, Francois, Rougeron, Virginie, Leroy, Eric   +18 more
openaire   +6 more sources

Diffusion‐MRI‐Based Estimation of Cortical Architecture via Machine Learning (DECAM) in Primate Brains

Advanced Science, EarlyView.
We present Diffusion‐MRI‐based Estimation of Cortical Architecture via Machine Learning (DECAM), a deep‐learning framework for estimating primate brain cortical architecture optimized with best response constraint and cortical label vectors. Trained using macaque brain high‐resolution multi‐shell dMRI and histology data, DECAM generates high‐fidelity ...
Tianjia Zhu, Minhui Ouyang, Shufang Tan, Jianlin Guo, Ziqin Zhang, Xuan Liu, Risheng Liu, Hao Huang   +7 more
wiley   +1 more source

An Evaluation of Twenty Years of EU Framework Programme-funded Immune-mediated Inflammatory Translational Research in Non-human Primates

Frontiers in Immunology, 2016
Ageing western societies are facing an increasing prevalence of chronic inflammatory and degenerative diseases for which often no effective treatments exist, resulting in increasing health care expenditure.
Krista Geraldine Haanstra, Margreet Jonker, Margreet Jonker, Bert A 't Hart, Bert A 't Hart   +4 more
doaj   +1 more source

Unraveling the Morphological and Functional Maturation Mechanisms Underlying Human Neural Development Using iPSCs‐Derived Neuronal Model

Advanced Science, EarlyView.
Using human induced pluripotent stem cells (hiPSCs)‐derived neuronal model, Tian and colleagues reveal that voltage‐gated calcium channels Cav1.2 and Cav1.3, and their mediated calcium ion influx, are essential for early morphogenesis of human neuronal development, while ECEL1 underlies human neuronal functional developmental maturation through CALM3 ...
Yue Tian, Yi‐Chun Ou, Zi‐Xian Zhang, Jie Cai, Si‐Qing Cai, Guo‐Gang Xing   +5 more
wiley   +1 more source

VDAC in Retinal Health and Disease

Biomolecules
The retina, a tissue of the central nervous system, is vital for vision as its photoreceptors capture light and transform it into electrical signals, which are further processed before they are sent to the brain to be interpreted as images. The retina is
Ying Xu, Shanti R. Tummala, Xiongmin Chen, Noga Vardi   +3 more
doaj   +1 more source

Primate malarias: Diversity, distribution and insights for zoonotic Plasmodium

One Health, 2015
Protozoans within the genus Plasmodium are well-known as the causative agents of malaria in humans. Numerous Plasmodium species parasites also infect a wide range of non-human primate hosts in tropical and sub-tropical regions worldwide.
Christina Faust, Andrew P. Dobson
doaj   +1 more source

Characterization of gut microbiome in a captive colony of marmosets

Berliner und Münchener Tierärztliche Wochenschrift, 2020
Although the microbiome signatures in primates are more similar to humans in comparison to microbiome of mice and rats, the study of microbiome in primate models and particularly in non-human primates such as the common marmoset (Callithrix jacchus) are ...
I J Knorr, L Benga, L Peitzmann, E Engelhardt, W Benten, C Gougoula, P Petzsch, K Köhrer, M Sager   +8 more
doaj   +1 more source

Host‐Directed Antiviral Activity of SB2960 Through Selective Induction and Remodeling of Stress Granules

Advanced Science, EarlyView.
Amid the ongoing threat of emerging viral pathogens, host‐directed antivirals offer a strategy to overcome viral mutation and drug resistance. SB2960, a small‐molecule inducer of stress granules (SGs), exhibits potent broad‐spectrum antiviral activity with minimal cytotoxicity.
Wan Gi Byun, Sumin Son, JinAh Lee, Minha Lee, Meehyun Ko, Songrui Zhao, Ju Hee Kim, Kannan Vaithegi, Ji Hoon Kwon, Jung Ho Lee, Sangeun Jeon, Dawon Yi, Peng Zou, Seungtaek Kim, Seung Bum Park   +14 more
wiley   +1 more source