Results 61 to 70 of about 156,532 (260)

Precise Control of Drug Release in Machine Learning‐Designed Antibody‐Eluting Implants for Postoperative Scarring Inhibition in Glaucoma

open access: yesAdvanced Healthcare Materials, EarlyView.
We developed a micro‐sized, biocompatible implant for postoperative sustained delivery of anti‐fibrotic antibodies in glaucoma surgery. Machine learning‐guided optimization of polymer composition, implant geometry, and porosity enabled precise control of drug release.
Mengqi Qin   +5 more
wiley   +1 more source

Investigation of depression-like phenotypes and their behavioral correlates in cynomolgus monkeys (Macaca fascicularis)

open access: yesBMC Zoology
Background The global burden of depression is heavy, with unclear pathogenesis, relying on animal models for researching neural mechanisms and treatments.
Wei Li, Li Huang, Shi-Gang Liu, Jun Tang
doaj   +1 more source

Variation in grouping patterns, mating systems and social structure: what socio-ecological models attempt to explain [PDF]

open access: yes, 2013
Socio-ecological models aim to predict the variation in social systems based on a limited number of ecological parameters. Since the 1960s, the original model has taken two paths: one relating to grouping patterns and mating systems and one relating to ...
Andreas Koenig   +19 more
core   +1 more source

Bone Healing Around Implants in Normal and Medically Compromised Conditions: Osteoporosis and Diabetes

open access: yesAdvanced Healthcare Materials, EarlyView.
xx xx. ABSTRACT Osseointegration of orthopedic and dental implants is influenced by local and systemic factors, including their physicochemical surface properties and the patient's overall health status. Titanium and its alloys have been a longstanding standard for bone implants due to their innate biocompatibility and mechanical properties.
Dainelys Guadarrama Bello   +2 more
wiley   +1 more source

Dilated cardiomyopathy in spider monkey (Ateles chamek, Humboldt, 1812)

open access: yesBrazilian Journal of Veterinary Medicine, 2019
Non-human primates are routinely studied and managed in zoos, conservation breeding centers, and research centers, but there is currently limited information regarding diseases that can affect these animals.
Mário dos Santos Filho   +7 more
doaj   +1 more source

The Situational Structure of Primate Beliefs [PDF]

open access: yes, 2016
This paper develops the situational model of primate beliefs from the Prior-Lurz line of thought. There is a strong skepticism concerning primate beliefs in the analytic tradition which holds that beliefs have to be propositional and non-human animals do
Cheng, Tony
core   +1 more source

Mapping the Cerebral Organoid Landscape: A Systematic Review of Preclinical 3D Models in Neuroscience

open access: yesAdvanced Healthcare Materials, EarlyView.
Cerebral organoids are transforming brain research, yet the field remains fragmented. This comprehensive systematic review maps 738 studies published between 2014 and 2024 to uncover trends, gaps, and opportunities across neuroscience. Introducing OrganoidMap—an interactive, open‐access platform to explore and compare models—this work enables ...
Anna Wolfram   +10 more
wiley   +1 more source

Gαi1/3 Is a Novel Regulatory Target for RANKL Signal Transduction and Osteoporosis

open access: yesAdvanced Science, EarlyView.
ABSTRACT Osteoporosis, characterized by progressive bone loss and increased fracture risk, is a growing concern as the population ages. Current treatments, though advanced, remain limited, underscoring the necessity for novel therapeutic targets. Recent studies have shown that the immune system plays a key role in osteoporosis, with osteoclasts driving
Chaowen Bai   +15 more
wiley   +1 more source

ATM deficiency drives phenotypic diversity and Purkinje cell degeneration in a macaque model of ataxia-telangiectasia

open access: yesCell Reports Medicine
Summary: Ataxia-telangiectasia (A-T) is a hereditary neurodegenerative disorder caused by mutations in the ATM (ataxia-telangiectasia mutated) gene. Although existing rodent models reproduce some of the multi-systemic features of A-T, they notably fail ...
Kaiyu Xu   +20 more
doaj   +1 more source

Theories about evolutionary origins of human hepatitis B virus in primates and humans

open access: yesBrazilian Journal of Infectious Diseases, 2014
Introduction: The human hepatitis B virus causes acute and chronic hepatitis and is considered one of the most serious human health issues by the World Health Organization, causing thousands of deaths per year.
Breno Frederico de Carvalho Dominguez Souza   +4 more
doaj   +1 more source

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