Results 51 to 60 of about 35,823 (237)

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

From a target group towards interaction group: Alcohol prevention policy regarding young people in Germany

Frontiers in Public Health, 2015
Background: Risk taking behaviour used to be a typical part of the adolescence period during which teenagers start learning to drink alcohol in their responsible way. Risky alcohol use has become a major concern among public health practioners in Europe.
Susanne Linden
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Macro-Financial Drivers and Spatial Dynamics of Construction Investment in African Regional Blocs

Romanian Economic Journal
This study empirically evaluates the interactive effects of real effective exchange rate (REXR) variations, real interest rates (RIRT), and money supply (VM2S) and the key determining factor of construction investment across seven African regional blocs (
David Umoru, Beauty Igbinovia, Muhammed Adamu Obomeghie, Imran Enike Abu, Emoabino Muhammed, Hilary Onoriode Obukohwo   +5 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Participation in river basin planning under the Water Framework Directive – Has it benefitted good water status?

Water Alternatives, 2020
The participation of societal groups and of the broader public has been a key feature in implementing the European Water Framework Directive (WFD).
Marlene Rimmert, Lucie Baudoin, Benedetta Cotta, Elisa Kochskämper, Jens Newig   +4 more
doaj  

Validation of the Knowledge Management Model Based on the Asian Productivity Organization (APO) Model in the Fars Province Water and Wastewater Company [PDF]

رویکرد‌های نوین در مدیریت و بازاریابی
The aim of the present study was to provide a comprehensive model for international entrepreneurship in ECO member countries. A mixed research method was used: in the qualitative part, data were collected and analyzed using systematic data-based theory ...
Mohammad Hassan Zamanifard, Sanjar Salajeghe, Mohammad Jalal Kamali, Navid Fatehi Rad   +3 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Presenting an International Entrepreneurship Model: A Case Study of ECO Member Countries [PDF]

رویکرد‌های نوین در مدیریت و بازاریابی
The aim of the present study was to provide a comprehensive model for international entrepreneurship in ECO member countries. A mixed research method was used: in the qualitative part, data were collected and analyzed using systematic data-based theory ...
mozhgan haji ghazi, mohamad mahdi mazaheri tehrani, freydoun rahnamay roodposhti   +2 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source