Results 101 to 110 of about 12,620,879 (241)

Identification of rare maternal copy number variants by genome-wide analysis of noninvasive prenatal screening data in 113,017 pregnant women

Annals of Medicine
Objectives Knowledge of copy number variants (CNVs) is relevant to maternal and fetal health and can be obtained from noninvasive prenatal screening (NIPS) of pregnancy.
Liang Hu, Xianzhen Cao, Shuxian Zeng, Lijuan Wen, Jiatong Zhong, Yanan Liu, Weiqiang Liu, Fengxiang Wei   +7 more
doaj   +1 more source

The association between non-invasive prenatal testing and first-trimester preeclampsia screening

Taiwanese Journal of Obstetrics & Gynecology
Objective: The non-invasive prenatal testing (NIPT) and preeclampsia screening test (PES) has been widely used to detect fetal chromosomal abnormalities and maternal preeclampsia during early pregnancy.
Ren-Jun Hsu, Chuang-Yen Huang, Pin-Chia Huang, Chao-Fan Liu, Fung-Wei Chang   +4 more
doaj   +1 more source

Non-invasive prenatal testing in Germany

, 2023
Abstract Non-invasive prenatal testing (NIPT) has been available commercially in Europe since approximately 2012. Currently, many countries are in the process of integrating NIPT into their publicly funded healthcare systems to screen for chromosomal aneuploidies such as trisomy 21 (Down syndrome), with a variety of implementation models.
Bowman-Smart, Hilary, Wiesemann, Claudia, Horn, Ruth   +2 more
openaire   +1 more source

Multi‐omics–driven precision medicine

iMeta, EarlyView.
Multi‐omics‐driven precision medicine (MODPM) provides a multiscale, continuously learnable framework that integrates genomics, epigenomics, transcriptomics, proteomics, metabolomics, microbiome profiles, and clinical data. Powered by artificial intelligence and foundation models, MODPM enables cross‐modal representation learning, contextual modeling ...
Huibo Li, Zhe Zhao, Yifan Zhang, Yao Ma, Gaofei Hu, Min Zeng, Zhanqun Yang, Zixuan Zhao, Xin Zhou, Wei Hu, Yuxuan Sun, Meng Su, Jun Li, Matthew Whiteman, Wei Fu, Chao Zhong, Lemin Zheng, Long Chen, Hairong Lv, Rongsheng Zhao, Yi Zhun Zhu   +20 more
wiley   +1 more source

Toward Small CNV Detection in NIPT: A Preliminary Analytical Evaluation of Sequencing Depth and Workflow Configuration

Diagnostics
Background/Objectives: Non-invasive prenatal testing (NIPT) performance is influenced by multiple biological and technical factors, including fetal fraction, sequencing depth, library preparation, and bioinformatic processing. This study aimed to compare
Pasquale Savarese, Valentina Ronga, Saveria Rivetti, Marianna De Simone, Roberta Coda, Claudia Quartotti, Lidia Copponi, Junlan Wu, Di Wu, Xin Liu, Marco Varelli   +10 more
doaj   +1 more source

Non-invasive prenatal testing to detect chromosome aneuploidies in 57,204 pregnancies

Molecular Cytogenetics, 2019
Background Non-invasive prenatal testing (NIPT) has been widely used to detect common fetal chromosome aneuploidies, such as trisomy 13, 18, and 21 (T13, T18, and T21), and has expanded to sex chromosome aneuploidies (SCAs) during recent years, but few ...
Ying Xue, Guodong Zhao, Hong Li, Qin Zhang, Jiafeng Lu, Bin Yu, Ting Wang   +6 more
doaj   +1 more source

Lactation, Childrearing, and Gender Justice

Journal of Applied Philosophy, EarlyView.
ABSTRACT In this article, I discuss the significance of early infant feeding choices for the goal of gender justice. Focusing on human lactation practices, I identify Exclusive Gestational Nursing (EGN) as the norm in advanced industrial societies, which creates the expectation and permission for gestators, and only gestators, to nurse children, and ...
Jenny Brown
wiley   +1 more source

Bisphenol M Induces Dose‐Dependent Hepatic Injury and Fibrotic Remodeling in Female Mice

Journal of Applied Toxicology, EarlyView.
ABSTRACT The safety of bisphenol analogs as alternatives to bisphenol A (BPA) is increasingly concerning. This study investigated the hepatotoxic effects of bisphenol M (BPM), a widely used BPA substitute, in 6‐week‐old female BALB/c mice exposed to 2.5, 5, and 10 mg/kg/day intraperitoneally for 14 days. Hepatic changes were assessed via histopathology,
Muhammed Canik, Asuman Deveci Ozkan, Tuğba Kotil, Nazan Deniz Yön   +3 more
wiley   +1 more source

First‐Trimester CBC‐Derived Inflammatory Indices for Prediction of Miscarriage: A Retrospective Cohort Study

Journal of Clinical Laboratory Analysis, EarlyView.
Maternal age was an independent predictor of miscarriage, and first‐trimester NLR and SII provided significant incremental predictive value. Because these indices are routinely derived from standard CBC testing without additional cost, they may serve as practical adjuncts to clinical risk factors for early miscarriage risk stratification.
Suchada Wattanaploy, Suchaya Luewan, Theera Tongsong   +2 more
wiley   +1 more source

Klippel‐Trénaunay‐Weber Syndrome: Prenatal Diagnosis and Review of the Literature

Journal of Clinical Ultrasound, Volume 53, Issue 3, Page 535-546, March/April 2025.
This meta‐analysis demonstrates the high diagnostic accuracy of SZ‐CEUS for differentiating between malignant and benign focal liver lesions, as well as for HCC from non‐HCC lesions. The study shows better performance for smaller lesions and those with a higher proportion of malignancy.
Giuliana Orlandi, Laura Sarno, Antonio Angelino, Mariarosaria Motta, Raffaella Di Girolamo, Luigi Carbone, Marika Rovetto, Laura Letizia Mazzarelli, Gabriella Sglavo, Francesco D' Antonio, Ilenia Mappa, Daniele Di Mascio, Giuseppe Rizzo, Giuseppe Maria Maruotti   +13 more
wiley   +1 more source