Results 41 to 50 of about 56,092 (268)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Two-photon all-optical neurophysiology for the dissection of larval zebrafish brain functional and effective connectivity

Communications Biology
One of the most audacious goals of modern neuroscience is unraveling the complex web of causal relations underlying the activity of neuronal populations on a whole-brain scale.
Lapo Turrini, Pietro Ricci, Michele Sorelli, Giuseppe de Vito, Marco Marchetti, Francesco Vanzi, Francesco Saverio Pavone   +6 more
doaj   +1 more source

Overcoming the thermal regime for the electric-field driven Mott transition in vanadium sesquioxide

Nature Communications, 2019
Thermal effects limit the speed of the electrically driven insulator-metal transition in V2O3 to tens of picoseconds. Here the authors show that under an intense THz-electric-field excitation the thermal regime can be overcome, achieving a purely ...
Flavio Giorgianni, Joe Sakai, Stefano Lupi   +2 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Combined Rehabilitation Promotes the Recovery of Structural and Functional Features of Healthy Neuronal Networks after Stroke

Cell Reports, 2019
Summary: Rehabilitation is considered the most effective treatment for promoting the recovery of motor deficits after stroke. One of the most challenging experimental goals is to unambiguously link brain rewiring to motor improvement prompted by ...
Anna Letizia Allegra Mascaro, Emilia Conti, Stefano Lai, Antonino Paolo Di Giovanna, Cristina Spalletti, Claudia Alia, Alessandro Panarese, Alessandro Scaglione, Leonardo Sacconi, Silvestro Micera, Matteo Caleo, Francesco Saverio Pavone   +11 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Cavity optomechanics in a fiber cavity: the role of stimulated Brillouin scattering

New Journal of Physics, 2022
We study the role of stimulated Brillouin scattering in a fiber cavity by numerical simulations and a simple theoretical model and find good agreement between experiment, simulation and theory.
A Beregi, A Pontin, P F Barker
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Ultra-fast force-clamp spectroscopy data on the interaction between skeletal muscle myosin and actin

Data in Brief, 2019
Ultrafast force-clamp spectroscopy is a single molecule technique based on laser tweezers with sub-millisecond and sub-nanometer resolution. The technique has been successfully applied to investigate the rapid conformational changes that occur when a ...
Manuela Maffei, Diego Beneventi, Monica Canepari, Roberto Bottinelli, Francesco Saverio Pavone, Marco Capitanio   +5 more
doaj   +1 more source

Geometrically robust linear optics from non-Abelian geometric phases

Physical Review Research, 2022
We construct a unified operator framework for quantum holonomies generated from bosonic systems. For a system whose Hamiltonian is bilinear in the creation and annihilation operators, we find a holonomy group determined only by a set of selected ...
Julien Pinske, Stefan Scheel
doaj   +1 more source