Results 31 to 40 of about 26,358 (263)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Study on Control Technology of Non-metallic Inclusions in 25MnBM Steel for Track Plate
Teshugang, 2020 The 25MnBM track plate steel is produced by 50 ton EAF short process. The control technology of TiN inclusions and the effect of RE on non-metallic inclusions in 25MnBM of steel are studied.
卢乃双, 梁娜, 黄涛
doaj
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Modification of Non-Metallic Inclusions in Stainless Steel by Addition of CaSi
Metals, 2019 The focus of this study involved comparative investigations of non-metallic inclusions in 316L stainless steel bars without and with Ca treatments. The inclusions were extracted by using electrolytic extraction (EE).
Hongying Du +3 more
doaj +1 more source
Methods for reducing nonmetallic inclusions in coatings applied by laser surfacing
RUDN Journal of Engineering Research, 2023 The results of experimental studies based on the analysis of deposited coatings and processing methods aimed at reducing the number of non-metallic inclusions in the process of laser powder cladding are presented.
Alexey V. Zavitkov +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Non-metallic inclusions and plasticity of steels
, 2020 The problems of the influence of non-metallic inclusions in the technological plasticity and mechanical properties of steels are discussed. The results of the study of deformation and destruction of non-metallic inclusions in steel treatment pressure in various conditions were listed.
Gubenko, S., Mamuzić, Ilija
openaire +3 more sources
FEBS Open Bio, EarlyView.Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata +13 more
wiley +1 more source
Versatile vector tools for efficient protein screening across multiple expression systems
FEBS Open Bio, EarlyView.A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu +5 more
wiley +1 more source
Materials & Design, 2022 This work studies the acicular ferrite (AF) nucleation and growth from a classical defect, i.e. non-metallic inclusion surface. The heterogeneous AF-nucleation probability on NMI is predicted by a mathematical model following the classical nucleation ...
Changji Xuan, Wangzhong Mu
doaj +1 more source