Results 51 to 60 of about 262,123 (293)

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

open access: yesFEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn   +4 more
wiley   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

open access: yesFEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman   +4 more
wiley   +1 more source

Numerical Analysis of RTD Curves and Inclusions Removal in a Multi-Strand Asymmetric Tundish with Different Configuration of Impact Pad

open access: yesMetals, 2020
To effectively remove non-metallic inclusions from the steel during the flowing in a five-strand asymmetric tundish, the novel configuration of the impact pad was developed. For analysis, complex numerical modelling in the programme ANSYS Fluent was used.
Markéta Tkadlečková   +3 more
doaj   +1 more source

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

open access: yesFEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa   +2 more
wiley   +1 more source

Study on Cleanliness Controlling of Liquid of Low Carbon Al-killed 0.20 C Steel

open access: yesTeshugang, 2022
In order to study the control technology of nonmetallic inclusions in aluminum deoxidized 0. 20 C steel (/% :0. 13 ~0.23C,0. 17 〜0.37Si,0.35 ~0.65Mn, ≤ 0.035P, ≤ 0.035S,0.020 - 0.050Al) produced by the process of “120 t BOF-LF-RH-160 mm x 160 mm billet ...
屠兴圹   +5 more
doaj  

Deformation and fracture of non-metallic inclusions in steel at different temperatures

open access: yesJournal of Materials Research and Technology, 2020
Experiments were carried out to investigate the deformation and fracture of non-metallic inclusions in steel at different temperatures. The deformation of inclusions at high temperature could be characterized by viscosity.
Wen Yang   +3 more
doaj   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

open access: yesFEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke   +4 more
wiley   +1 more source

EFFECT OF SULPHUR ON WETTABILITY OF LIQUID FE-0.45%C WITH ALUMINA

open access: yesMateriali in Tehnologije
Non-metallic inclusions, particularly alumina (Al2O3), pose significant challenges in steelmaking. Their behaviour in molten steel is largely governed by wettability.
Anže Bajželj   +2 more
doaj   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

open access: yesFEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee   +6 more
wiley   +1 more source

Influence of Non-Metallic Inclusions on Very High-Cycle Fatigue Performance of High-Strength Steels and Interpretation via Crystal Plasticity Finite Element Method

open access: yesMetals
The fatigue behaviors of high-strength bearing steel were investigated with rotating bending fatigue loading with a frequency of 52.5 Hz. It was revealed that the high-strength steel tended to initiate at interior non-metallic inclusions in a very high ...
Yingxin Zhao   +5 more
doaj   +1 more source

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