Results 41 to 50 of about 24,809 (265)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Non-metallic inclusions and plasticity of steels

, 2020
The problems of the influence of non-metallic inclusions in the technological plasticity and mechanical properties of steels are discussed. The results of the study of deformation and destruction of non-metallic inclusions in steel treatment pressure in various conditions were listed.
Gubenko, S., Mamuzić, Ilija
openaire   +3 more sources

Effect of the morphologies of non-metallic inclusions on their removal behavior

工程科学学报, 2016
The differences in shape correction coefficient(SCC) of common inclusions in molten steel including spherical,cubic,cylindrical,dendritic and cluster particles were studied by a physical simulation method.
WANG Min, HAO Yang, MA Cheng-you, WANG Lin-jing   +3 more
doaj   +1 more source

Numerical Analysis of RTD Curves and Inclusions Removal in a Multi-Strand Asymmetric Tundish with Different Configuration of Impact Pad

Metals, 2020
To effectively remove non-metallic inclusions from the steel during the flowing in a five-strand asymmetric tundish, the novel configuration of the impact pad was developed. For analysis, complex numerical modelling in the programme ANSYS Fluent was used.
Markéta Tkadlečková, Josef Walek, Karel Michalek, Tomáš Huczala   +3 more
doaj   +1 more source

Research on Intelligent Identification and Grading of Nonmetallic Inclusions in Steels Based on Deep Learning

Micromachines, 2023
Non-metallic inclusions are unavoidable defects in steel, and their type, quantity, size, and distribution have a great impact on the quality of steel. At present, non-metallic inclusions are mainly detected manually, which features high work intensity ...
Xiaolin Zhu, Wenhai Wan, Ling Qian, Yu Cai, Xiang Chen, Pingze Zhang, Guanxi Huang, Bo Liu, Qiang Yao, Shaoyuan Li, Zhengjun Yao   +10 more
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Deformation and fracture of non-metallic inclusions in steel at different temperatures

Journal of Materials Research and Technology, 2020
Experiments were carried out to investigate the deformation and fracture of non-metallic inclusions in steel at different temperatures. The deformation of inclusions at high temperature could be characterized by viscosity.
Wen Yang, Kaiyu Peng, Lifeng Zhang, Qiang Ren   +3 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source