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Quantitation of non‐motor symptoms in Parkinson’s disease
European Journal of Neurology, 2008Background: Disabling non‐motor symptoms (NMS) associated with Parkinson’s disease (PD), such as dementia and loss of balance, do not respond well to levodopa therapy and can lead to eventual death in patients with the disease. In 2006, a multidisciplinary group of experts and patient representatives developed an NMS screening questionnaire (NMSQuest)
Chaudhuri, K Ray, Martinez-Martin, P
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Brainstem pathology and non-motor symptoms in PD
Journal of the Neurological Sciences, 2010Parkinson's disease (PD) is considered a multisystem disorder involving dopaminergic, noradrenergic, serotoninergic, and cholinergic systems, characterized by motor and non-motor symptoms. The causes of the non-motor symptoms in PD are multifactorial and unlikely to be explained by single lesions.
Lea Tenenholz, Grinberg +3 more
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Neuropathobiology of non-motor symptoms in Parkinson disease
Journal of Neural Transmission, 2015Parkinson disease (PD) is a multisystem disorder associated with α-synuclein aggregates throughout the central, autonomic, and peripheral nervous system, clinically characterized by motor and non-motor (NM) symptoms. The NMS in PD, many of which antedating motor dysfunction and representing a preclinical phase spanning 20 or more years, are linked to ...
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Sarcopenia as a non-motor symptom of Parkinson’s disease
S.S. Korsakov Journal of Neurology and PsychiatrySarcopenia is a progressive generalized skeletal muscle disease that is accompanied by an accelerated loss of muscle mass and function, affecting the quality of life and the ability to perform self-care. The prevalence of sarcopenia in the world today ranges from 10 to 25%, which represents a certain danger as it is a prognostic factor for possible ...
N.G. Zhukova +6 more
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The challenge of non-motor symptoms in Parkinson’s disease
2010The non-motor symptoms (NMS) of Parkinson's disease (PD) are often poorly recognized and inadequately treated in contrast to motor symptoms and a modern holistic approach to treatment of PD should, therefore, include recognition and assessment of NMS.
K Ray, Chaudhuri, Per, Odin
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Non-motor symptoms in Parkinson's disease: An explorative network study
Parkinsonism & Related Disorders, 2019Research on the association between non-motor symptoms (NMS) of Parkinson's disease (PD) and patients' quality of life (QoL) has given insight into the burden of NMS. Most studies investigate NMS by assessing the contribution of individual symptoms to QoL.
Engels, Gwenda +5 more
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Non-motor Symptoms and Treatments in Parkinson’s Disease
Neurologic ClinicsParkinson's disease (PD) is a neurodegenerative disorder characterized by motor and non-motor symptoms. The non-motor features may precede the onset of motor symptoms and occur throughout all stages of PD. The non-motor symptoms reflect multisystem involvement of the central and peripheral nervous systems, multiple neurotransmitters, and multiple ...
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Non-motor symptom subtypes in early Parkinson's disease
Parkinsonism & Related DisordersParkinson's disease (PD) is a clinically heterogeneous disorder characterized by a broad spectrum of non-motor symptoms. Defining non-motor subtypes may help clarify early pathophysiological mechanisms, predict disease progression, and guide personalized care.To identify non-motor PD subtypes through an unsupervised approach, evaluate their consistency
Vittorio Velucci +7 more
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Are hiccups non-motor symptoms?
Parkinsonism & Related Disorders, 2010Juan Giugni +2 more
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