Results 161 to 170 of about 11,745,756 (213)
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Effects of Non-Narcotic Analgesics on the Liver
Drugs, 1986Serious hepatotoxicity is uncommon with the proper therapeutic use of non-narcotic analgesics but experience with new non-steroidal anti-inflammatory drugs (NSAIDs) is limited. Drugs such as ibufenac, fenclofenac and benoxaprofen were withdrawn from the market because of hepatotoxicity, and liver damage has been reported on occasion with virtually all ...
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Effects of Non-Narcotic Analgesics on the Kidney
Drugs, 1986Non-narcotic analgesics have acute and chronic effects on the kidney. Until quite recently chronic effects have received much more attention than acute effects. Renal papillary necrosis attributed to prolonged intake of analgesic compounds was first described from Switzerland in the 1950s, and subsequently in many countries including Scandinavia ...
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Flunixin meglumine: a non-narcotic analgesic.
The Journal of Pharmacology and Experimental Therapeutics, 1977The N-methyl-d-glucamine salt of flunixin (flunixin meglumine) is a potent non-narcotic analgesic agent after parenteral administration in mice, rats and monkeys. It is significantly more potent than pentazocine, meperidine and codeine in the rat yeast paw test after subcutaneous administration in saline.
V B, Ciofalo +3 more
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Pharmaceutical Research, 1989 Relationships between the in vitro permeation rates of select narcotic analgesics through human skin and their physicochemical properties were investigated by following the permeation kinetics of six representative compounds in small diffusion cells. The
Gordon L Flynn, S D Roy, G L Flynn
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Pharmacokinetics of a non-narcotic analgesic, DA-5018, in rats
Biopharmaceutics & Drug Disposition, 1998The pharmacokinetics of a non-narcotic analgesic, DA-5018, were compared after single intravenous (i.v.), subcutaneous (s.c.), and oral administrations, and after multiple (seven consecutive days) s.c. administration to rats. After i.v. administration of DA-5018, 1, 2, and 5 mg kg-1, the pharmacokinetic parameters of DA-5018 were independent of the ...
J J, Lee +6 more
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Gastrointestinal Intolerance and Bleeding with Non-Narcotic Analgesics
Drugs, 1986Aspirin and paracetamol (acetaminophen) are the most commonly used minor analgesics, but their effects on the gastrointestinal tract differ widely. The effects of other nonsteroidal anti-inflammatory drugs (NSAIDs), including phenylbutazone, are intermediate.
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Potentiation of a non-narcotic analgesic, dipyrone, by cholinomimetic drugs
Psychopharmacologia, 1972Dipyrone analgesia in mice was potentiated by physostigmine, neostigmine and pilocarpine. This potentiation was antagonized by atropine sulfate and atropine methyl nitrate. Tremorine and dextroamphetamine which implicate brain monoamines in their analgesic effects, were inactive, as were carbachol and nicotine.
U G, Kamat, R J, Pradhan, U K, Sheth
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Blockade by l-lysine of non-narcotic analgesics.
The Journal of Pharmacology and Experimental Therapeutics, 1980The antinociceptive effects of the non-narcotic analgesics clonixin, flunixin, acetylsalicylic acid, aminopyrine and phenylbutazone in the yeast paw test were blocked by l-lysine. Blockade occurred at doses of l-lysine which did not affect pain threshold. The site(s) or mechanism of action of blockade could not be determined with certainty.
L C, Iorio +3 more
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Non-Narcotics and Co-Analgesics
1984Aspirin and other non-steroidal antiinflammatory drugs (NSAIDs) and paracetamol are the most important of the non-narcotic analgesics. As simple analgesics they have equal potency but paracetamol is generally better tolerated, particularly with regard to gastrointestinal side-effects1.
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Impact of non-narcotic oral analgesics on pain management
The American Journal of Medicine, 1988Of the four categories of oral analgesics, three have been available since the 19th century. Although adequate doses of the more potent oral opioids such as morphine and methadone are effective even in severe pain, the commonly used "weak" narcotics such as codeine and propoxyphene are no more effective than usual doses of aspirin or acetaminophen ...
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