Results 91 to 100 of about 13,597,353 (325)
Stewardship of Test-Free Nuclear Arsenals [PDF]
, 2006 Maintaining nuclear arms in the current policy environment that frowns upon weapons testing coexists with a set of unresolved and disquieting issues regarding the disposition of test-free arsenals.
Ivan Safranchuk, Vladimir Belous
core
Frontiers in Public HealthThe German Biosecurity Programme was launched in 2013 with the aim to support partner countries overcome biological threats including natural outbreaks or the intentional misuse of highly pathogenic agents. As part of this programme, this paper describes
Eva Mertens +18 more
doaj +1 more source
The evolution of the U.S. nuclear non-proliferation policy in the 1970s
Journal of Human Environmental Studies, 2009 This paper examines (1) how the Ford Administration tried to persuade South Korea to give up obtaining the spent nuclear fuel reprocessing plant and their related technologies, which were one of the most sensitive among peaceful nuclear use, and (2) how ...
Shinsuke Tomotsugu
doaj +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Dispositioning military plutonium to promote nuclear non-proliferation [PDF]
, 2005 Given that all chemical varieties of plutonium can be used in nuclear weapons, sophisticated measures are required to disposition it so that its potential to contribute to horizontal and vertical nuclear proliferation is minimised.
Sancton, Robert
core
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
EnergiesThe ongoing efforts to convert High-Performance Research Reactors (HPRRs) using Highly Enriched Uranium (HEU) to Low-Enriched Uranium (LEU) fuel require reliable thermal–hydraulic assessments of modified core designs. The involute-shaped fuel plates used
Cezary Bojanowski +10 more
doaj +1 more source
Margalla Papers, 2023 The image the United States has always projected of itself in the international community is that of a state that is nuclear responsible and bears the responsibility to keep nuclear proliferation in check.
Asma Rashid , Aiman Saif Ullah
doaj
Sclerosing Angiomatoid Nodular Transformation: A Series of Four Cases [PDF]
Journal of Clinical and Diagnostic ResearchAmong the primary non haematopoietic neoplasms of the spleen, vascular neoplasms are the most common. These vascular neoplasms consist of haemangiomas, littoral cell angiomas, lymphangiomas, Splenic Hamartomas (SHs), haemangioendotheliomas, angiosarcomas
PP Mansoor +3 more
doaj +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source