Results 81 to 90 of about 12,076,128 (300)

Non-Proliferation law as a special regime

, 2012
The fragmentation of international law is an undeniable phenomenon and one that has met with increasing academic interest. This fragmentation is the result of the progressive expansion of both international legal activity and the subject-matter of ...

core  

Deubiquitylating enzyme, USP9X, regulates proliferation of cells of head and neck cancer lines

, 2016
Objectives Truncating mutations in USP9X have been identified in oral squamous cell carcinoma patients. The aim of this study was to determine USP9X's functional role, if any, in head and neck cancer cells.
Nguyen, Maria, Wood, SA, Nanayakkara, Devathri, D. M. Nanayakkara, S. A. Wood, Nanayakkara, DM, Nguyen, MN, Wood, Stephen, M. N. Nguyen   +8 more
core   +1 more source

Extended nuclear deterrence in Europe’s NATO security architecture and Kazakhstan’s denuclearized security model

Frontiers in Political Science
IntroductionThis study compares two asymmetrical security models in Eurasia: Europe’s NATO-centered security architecture, which relies on extended nuclear deterrence, and Kazakhstan’s institutionalized strategy of denuclearization.MethodsThe theoretical
ZuoYuan Liu, Anna Serebrennikova, Zara Shaimordanova, Bibigul Byulegenova, Igor Egorov   +4 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Commission on the Prevention of Weapons of Mass Destruction Proliferation and Terrorism

, 2008
The creation of the Commission, which was established by House Resolution 1, implements a key recommendation of the independent, bipartisan 9/11 Commission to address the grave threat that the proliferation of weapons of mass destruction poses to our ...
Commission on the Prevention of Weapons of Mass Destruction Proliferation and Terrorism (U.S.)
core  

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Does ursodeoxycholic acid change the proliferation of the colorectal mucosa? A randomized, placebo-controlled study [PDF]

, 2003
Background: In animal models ursodeoxycholic acid (UDCA) showed a chemoprotective effect against colon cancer. To explain this, a reduced proliferation of the colorectal mucosal proliferation was suggested.
Burkhard Göke, Marsteller, I., Paumgartner, Gustav, Göke, B., Ochsenkühn, Thomas, Thomas Ochsenkühn, Hay, U., Igor Marsteller, Sackmann, M., Michael Sackmann, Joachim Diebold, Diebold, J., Ulrich Hay, Gustav Paumgartner   +13 more
core   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Civil society legitimacy and nuclear non-proliferation [PDF]

During recent years, civil society legitimacy has generated a growing interest in scholarly research. The present article therefore proposes four normative criteria, namely, independence, transparency, participation, and inclusion, in order to start ...
Kissling, Claudia
core  

The GIBACHT fellowship: a multilateral initiative for strengthening capacity in biosafety and biosecurity towards pandemic preparedness

Frontiers in Public Health
The German Biosecurity Programme was launched in 2013 with the aim to support partner countries overcome biological threats including natural outbreaks or the intentional misuse of highly pathogenic agents. As part of this programme, this paper describes
Eva Mertens, Eva Mertens, Marlow Zimmermann, Marlow Zimmermann, Janine Dywicki, Janine Dywicki, Min-Hi Lee, Min-Hi Lee, Joachim Pelikan, Joachim Pelikan, Joachim Pelikan, Barbara M. Bürkin, Barbara M. Bürkin, Barbara M. Bürkin, Elizeus Rutebemberwa, Elizeus Rutebemberwa, Axel Hoffmann, Axel Hoffmann, Axel Hoffmann   +18 more
doaj   +1 more source