Results 51 to 60 of about 12,220,401 (374)
The role of histone modifications in transcription regulation upon DNA damage
FEBS Letters, EarlyView.This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley +1 more source
Subcontinental Nuclear Instability: The Spiralling Nightmare
International Journal of Nuclear Security, 2015 The scheme that carved world order during the Cold War was a pitched battle for 'containment' against burgeoning communism. In turn, rationality gave way to the threat of catastrophic nuclear force as the basis of stability.
Vijay Shankar
doaj +1 more source
Cancer Cell International, 2021 Background Hepatocellular carcinoma (HCC) is a common cancer leading to high morbidity and mortality in worldwide. Previous studies revealed that SEC61 translocon alpha 1 subunit1 (SEC61A) can act as an oncogene in colon adenocarcinoma.
Xinxin Fa +4 more
doaj +1 more source
Atlanta Consultation II: On the Future of the NPT [PDF]
, 2005 The Middle Powers Initiative, a program of the Global Security Institute, organized an Extraordinary Strategy Consultation on the Nuclear Non-proliferation Treaty (NPT) 2005 Review Conference in cooperation with former U.S.
core
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Between Human Rights and Non-proliferation: Norm Competition in the EU’s Iran Policy
, 2014 The European Union has been a prominent player in the negotiations with Iran since the beginning of the Iranian nuclear crisis in 2002. However, the Union’s Iran policy cannot be reduced to the field of nuclear non-proliferation.
Benjamin Kienzle
semanticscholar +1 more source
North Korea and the Non-proliferation Regime [PDF]
, 2009 In this review of the implications of North Korea’s behaviour during 2009 on the Non-proliferation Regime, it is stressed that if North Korea cannot be deterred from its nuclear ambitions this will deliver a serious blow to the international non ...
Reiss, Mitchell B.
core +1 more source
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Civil society legitimacy and nuclear non-proliferation [PDF]
, 2008 During recent years, civil society legitimacy has generated a growing interest in scholarly research. The present article therefore proposes four normative criteria, namely, independence, transparency, participation, and inclusion, in order to start ...
Kissling, Claudia
core
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source